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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11260

FusionGeneSummary for EIF3D_PSMD13

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3D_PSMD13
Fusion gene ID: 11260
HgeneTgene
Gene symbol

EIF3D

PSMD13

Gene ID

8664

5719

Gene nameeukaryotic translation initiation factor 3 subunit Dproteasome 26S subunit, non-ATPase 13
SynonymsEIF3S7|eIF3-p66|eIF3-zetaHSPC027|Rpn9|S11|p40.5
Cytomap

22q12.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit26S proteasome non-ATPase regulatory subunit 1326S proteasome regulatory subunit RPN926S proteasome regulatory subunit S1126S proteasome regulatory subunit p40.526S proteasome subunit p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
Modification date2018052320180523
UniProtAcc

O15371

Q9UNM6

Ensembl transtripts involved in fusion geneENST00000216190, ENST00000478547, 
ENST00000541106, ENST00000405442, 
ENST00000532097, ENST00000431206, 
ENST00000352303, ENST00000532025, 
Fusion gene scores* DoF score9 X 10 X 4=3604 X 3 X 4=48
# samples 114
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3D [Title/Abstract] AND PSMD13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3D

GO:0002191

cap-dependent translational initiation

27462815

HgeneEIF3D

GO:0006413

translational initiation

17581632

HgeneEIF3D

GO:0075522

IRES-dependent viral translational initiation

9573242

HgeneEIF3D

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF768948EIF3Dchr22

36916733

+PSMD13chr11

252820

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000216190ENST00000532097EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000216190ENST00000431206EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000216190ENST00000352303EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000216190ENST00000532025EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000478547ENST00000532097EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000478547ENST00000431206EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000478547ENST00000352303EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000478547ENST00000532025EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000541106ENST00000532097EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000541106ENST00000431206EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000541106ENST00000352303EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000541106ENST00000532025EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000405442ENST00000532097EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000405442ENST00000431206EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000405442ENST00000352303EIF3Dchr22

36916733

+PSMD13chr11

252820

+
intron-3UTRENST00000405442ENST00000532025EIF3Dchr22

36916733

+PSMD13chr11

252820

+

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FusionProtFeatures for EIF3D_PSMD13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3D

O15371

PSMD13

Q9UNM6

mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}. Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF3D_PSMD13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF3D_PSMD13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF3D_PSMD13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF3D_PSMD13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePSMD13C0019693HIV Infections1CTD_human