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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11242

FusionGeneSummary for EIF3A_SLCO1B1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3A_SLCO1B1
Fusion gene ID: 11242
HgeneTgene
Gene symbol

EIF3A

SLCO1B1

Gene ID

8661

10599

Gene nameeukaryotic translation initiation factor 3 subunit Asolute carrier organic anion transporter family member 1B1
SynonymsEIF3|EIF3S10|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185HBLRR|LST-1|LST1|OATP-C|OATP1B1|OATP2|OATPC|SLC21A6
Cytomap

10q26.11

12p12.1

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit AEIF3, p180 subunitcentrosomin homologcytoplasmic protein p167eIF-3-thetaeIF3 p167eIF3 p180eIF3 p185eukaryotic translation initiation factor 3 subunit 10eukaryotic translation initiation factor 3solute carrier organic anion transporter family member 1B1OATP-2liver-specific organic anion transporter 1sodium-independent organic anion-transporting polypeptide 2solute carrier family 21 (organic anion transporter), member 6
Modification date2018052320180523
UniProtAcc

Q14152

Q9Y6L6

Ensembl transtripts involved in fusion geneENST00000369144, ENST00000541549, 
ENST00000256958, 
Fusion gene scores* DoF score6 X 6 X 2=724 X 3 X 4=48
# samples 64
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3A [Title/Abstract] AND SLCO1B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF3A

GO:0001732

formation of cytoplasmic translation initiation complex

17581632

HgeneEIF3A

GO:0075522

IRES-dependent viral translational initiation

9573242|23766293|24357634

HgeneEIF3A

GO:0075525

viral translational termination-reinitiation

21347434


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI207430EIF3Achr10

120801566

-SLCO1B1chr12

21294366

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000369144ENST00000256958EIF3Achr10

120801566

-SLCO1B1chr12

21294366

+
intron-intronENST00000541549ENST00000256958EIF3Achr10

120801566

-SLCO1B1chr12

21294366

+

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FusionProtFeatures for EIF3A_SLCO1B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3A

Q14152

SLCO1B1

Q9Y6L6

RNA-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, which is required for severalsteps in the initiation of protein synthesis (PubMed:17581632,PubMed:25849773). The eIF-3 complex associates with the 40Sribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiationcomplex (43S PIC). The eIF-3 complex stimulates mRNA recruitmentto the 43S PIC and scanning of the mRNA for AUG recognition. TheeIF-3 complex is also required for disassembly and recycling ofpost-termination ribosomal complexes and subsequently preventspremature joining of the 40S and 60S ribosomal subunits prior toinitiation (PubMed:17581632, PubMed:11169732). The eIF-3 complexspecifically targets and initiates translation of a subset ofmRNAs involved in cell proliferation, including cell cycling,differentiation and apoptosis, and uses different modes of RNAstem-loop binding to exert either translational activation orrepression (PubMed:25849773, PubMed:27462815). {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:11169732,ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) Essential for the initiation oftranslation on type-1 viral ribosomal entry sites (IRESs), likefor HCV, PV, EV71 or BEV translation (PubMed:23766293,PubMed:24357634). {ECO:0000269|PubMed:23766293,ECO:0000269|PubMed:24357634}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}. Mediates the Na(+)-independent uptake of organic anionssuch as pravastatin, taurocholate, methotrexate,dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol,estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3,leukotriene E4, thyroxine and triiodothyronine. Involved in theclearance of bile acids and organic anions from the liver.{ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278,ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:22232210}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF3A_SLCO1B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF3A_SLCO1B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF3A_SLCO1B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLCO1B1Q9Y6L6DB01045RifampicinSolute carrier organic anion transporter family member 1B1small moleculeapproved
TgeneSLCO1B1Q9Y6L6DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1small moleculeapproved
TgeneSLCO1B1Q9Y6L6DB05521TelaprevirSolute carrier organic anion transporter family member 1B1small moleculeapproved|withdrawn

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RelatedDiseases for EIF3A_SLCO1B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF3AC0033578Prostatic Neoplasms1CTD_human
TgeneSLCO1B1C0026848Myopathy5CTD_human
TgeneSLCO1B1C0041755Adverse reaction to drug1CTD_human
TgeneSLCO1B1C1458155Mammary Neoplasms1CTD_human