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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11225

FusionGeneSummary for EIF2S1_EIF2S1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF2S1_EIF2S1
Fusion gene ID: 11225
HgeneTgene
Gene symbol

EIF2S1

EIF2S1

Gene ID

1965

1965

Gene nameeukaryotic translation initiation factor 2 subunit alphaeukaryotic translation initiation factor 2 subunit alpha
SynonymsEIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2AEIF-2|EIF-2A|EIF-2alpha|EIF2|EIF2A
Cytomap

14q23.3

14q23.3

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 2 subunit 1eIF-2-alphaeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDaeukaryotic translation initiation factor 2 subunit 1eIF-2-alphaeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Modification date2018052320180523
UniProtAcc

P05198

P05198

Ensembl transtripts involved in fusion geneENST00000256383, ENST00000466499, 
ENST00000256383, ENST00000466499, 
Fusion gene scores* DoF score4 X 5 X 4=801 X 1 X 1=1
# samples 51
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: EIF2S1 [Title/Abstract] AND EIF2S1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA450266EIF2S1chr14

67850381

-EIF2S1chr14

67850306

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000256383ENST00000256383EIF2S1chr14

67850381

-EIF2S1chr14

67850306

+
3UTR-3UTRENST00000256383ENST00000466499EIF2S1chr14

67850381

-EIF2S1chr14

67850306

+
3UTR-3UTRENST00000466499ENST00000256383EIF2S1chr14

67850381

-EIF2S1chr14

67850306

+
3UTR-3UTRENST00000466499ENST00000466499EIF2S1chr14

67850381

-EIF2S1chr14

67850306

+

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FusionProtFeatures for EIF2S1_EIF2S1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF2S1

P05198

EIF2S1

P05198

Functions in the early steps of protein synthesis byforming a ternary complex with GTP and initiator tRNA. Thiscomplex binds to a 40S ribosomal subunit, followed by mRNA bindingto form a 43S pre-initiation complex. Junction of the 60Sribosomal subunit to form the 80S initiation complex is precededby hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyzeanother round of initiation, the GDP bound to eIF-2 must exchangewith GTP by way of a reaction catalyzed by eIF-2B. Functions in the early steps of protein synthesis byforming a ternary complex with GTP and initiator tRNA. Thiscomplex binds to a 40S ribosomal subunit, followed by mRNA bindingto form a 43S pre-initiation complex. Junction of the 60Sribosomal subunit to form the 80S initiation complex is precededby hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyzeanother round of initiation, the GDP bound to eIF-2 must exchangewith GTP by way of a reaction catalyzed by eIF-2B.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF2S1_EIF2S1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EIF2S1_EIF2S1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF2S1_EIF2S1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF2S1_EIF2S1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF2S1C0002395Alzheimer's Disease1CTD_human
HgeneEIF2S1C0009241Cognition Disorders1CTD_human
HgeneEIF2S1C0027746Nerve Degeneration1CTD_human
HgeneEIF2S1C0029463Osteosarcoma1CTD_human
HgeneEIF2S1C0036341Schizophrenia1PSYGENET
HgeneEIF2S1C0038220Status Epilepticus1CTD_human
TgeneEIF2S1C0002395Alzheimer's Disease1CTD_human
TgeneEIF2S1C0009241Cognition Disorders1CTD_human
TgeneEIF2S1C0027746Nerve Degeneration1CTD_human
TgeneEIF2S1C0029463Osteosarcoma1CTD_human
TgeneEIF2S1C0036341Schizophrenia1PSYGENET
TgeneEIF2S1C0038220Status Epilepticus1CTD_human