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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 11201

FusionGeneSummary for EIF2AK2_STRN

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF2AK2_STRN
Fusion gene ID: 11201
HgeneTgene
Gene symbol

EIF2AK2

STRN

Gene ID

5610

6801

Gene nameeukaryotic translation initiation factor 2 alpha kinase 2striatin
SynonymsEIF2AK1|PKR|PPP1R83|PRKRPPP2R6A|SG2NA|STRN1
Cytomap

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-indstriatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding protein
Modification date2018052320180523
UniProtAcc

P19525

O43815

Ensembl transtripts involved in fusion geneENST00000233057, ENST00000395127, 
ENST00000405334, 
ENST00000263918, 
ENST00000379213, 
Fusion gene scores* DoF score4 X 5 X 3=602 X 1 X 1=2
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/2*10)=3.32192809488736
Context

PubMed: EIF2AK2 [Title/Abstract] AND STRN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF2AK2

GO:0006468

protein phosphorylation

19189853

HgeneEIF2AK2

GO:0017148

negative regulation of translation

12882984

HgeneEIF2AK2

GO:0035455

response to interferon-alpha

19840259

HgeneEIF2AK2

GO:0046777

protein autophosphorylation

22801494

HgeneEIF2AK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15121867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-OL-A5D8-01AEIF2AK2chr2

37341874

-STRNchr2

37152351

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000233057ENST00000263918EIF2AK2chr2

37341874

-STRNchr2

37152351

-
Frame-shitENST00000233057ENST00000379213EIF2AK2chr2

37341874

-STRNchr2

37152351

-
Frame-shitENST00000395127ENST00000263918EIF2AK2chr2

37341874

-STRNchr2

37152351

-
Frame-shitENST00000395127ENST00000379213EIF2AK2chr2

37341874

-STRNchr2

37152351

-
In-frameENST00000405334ENST00000263918EIF2AK2chr2

37341874

-STRNchr2

37152351

-
In-frameENST00000405334ENST00000379213EIF2AK2chr2

37341874

-STRNchr2

37152351

-

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FusionProtFeatures for EIF2AK2_STRN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF2AK2

P19525

STRN

O43815

IFN-induced dsRNA-dependent serine/threonine-proteinkinase which plays a key role in the innate immune response toviral infection and is also involved in the regulation of signaltransduction, apoptosis, cell proliferation and differentiation.Exerts its antiviral activity on a wide range of DNA and RNAviruses including hepatitis C virus (HCV), hepatitis B virus(HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1).Inhibits viral replication via phosphorylation of the alphasubunit of eukaryotic initiation factor 2 (EIF2S1), thisphosphorylation impairs the recycling of EIF2S1 between successiverounds of initiation leading to inhibition of translation whicheventually results in shutdown of cellular and viral proteinsynthesis. Also phosphorylates other substrates includingp53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral proteinUS11. In addition to serine/threonine-protein kinase activity,also has tyrosine-protein kinase activity and phosphorylates CDK1at 'Tyr-4' upon DNA damage, facilitating its ubiquitination andproteosomal degradation. Either as an adapter protein and/or viaits kinase activity, can regulate various signaling pathways (p38MAP kinase, NF-kappa-B and insulin signaling pathways) andtranscription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved inthe expression of genes encoding proinflammatory cytokines andIFNs. Activates the NF-kappa-B pathway via interaction with IKBKBand TRAF family of proteins and activates the p38 MAP kinasepathway via interaction with MAP2K6. Can act as both a positiveand negative regulator of the insulin signaling pathway (ISP).Negatively regulates ISP by inducing the inhibitoryphosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5Awhich activates FOXO1, which in turn up-regulates the expressionof insulin receptor substrate 2 (IRS2). Can regulate NLRP3inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 andNLRC4 inflammasomes. Can trigger apoptosis via FADD-mediatedactivation of CASP8. Plays a role in the regulation of thecytoskeleton by binding to gelsolin (GSN), sequestering theprotein in an inactive conformation away from actin.{ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380,ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216,ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853,ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191,ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114,ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959,ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651,ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662,ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494,ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476,ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543,ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035}. Calmodulin-binding protein which may function asscaffolding or signaling protein and may play a role in dendriticCa(2+) signaling.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EIF2AK2_STRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000263918_chr2_37152351_-_1121aa
MAGDLSAGFFMEELNTYRQKQGVVLKTQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNTEQCASGVHGPEGFHTKCKMGQKETSIGTGSTKQEAKQLAAKLATLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKTTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDTDPETSDDSLESSDTDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDTIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLETALK
QERAKYHKLKYGTELNQGDMKPPSTDSDEGNETEVQPQQNSQLMWKQGRQLLRQTLQEVGTTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRP
SSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTTDIANNKDALRKTWNPKFTLRSHFDGIRALA
FHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPITTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPTDSTDPSV
LRGPLLGHTDAVWGLATSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGTTSIFNMETQQRI
LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFTDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC

>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000379213_chr2_37152351_-_1084aa
MAGDLSAGFFMEELNTYRQKQGVVLKTQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNTEQCASGVHGPEGFHTKCKMGQKETSIGTGSTKQEAKQLAAKLATLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKTTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDTDPETSDDSLESSDTDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDTIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLETALK
QERAKYHKLKYGTELNQGDMKPPSTDSDEGNETEVQPQQNSQLMWKQGRQLLRQTLQEVGTTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWGPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEAL
ESELGLGELAGLTVANEADSLTTDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVE
PITTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPTDSTDPSVLRGPLLGHTDAVWGLATSAAHQRLLSCSADGTLRLWN
TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGTTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRH
IKFTDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCTIASAGADALAK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000263918_chr2_37152351_-_3363nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGAAAAGGAAGACCAGTGTCTCATGCCTGAA
GCCTGGAATGTGGACCAGGGAGTAATTACCAAACTCAAGGAACAATACAAAAAGGAGAGAAAGGGGAAAAAGGGGGTGAAGAGGCCCAAT
AGGTCAAAACTACAAGATATGCTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCC
AGCAGCTCCAGGCTTCCTGAACATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATC
ATGGGAGCAGATGAAGCCCTTGAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTAT
GATATAGCAAACAATAAAGATGCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCT
TTCCATCCCATTGAGCCTGTTTTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAG
AGCACTTCTCTTGATGTAGAACCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAG
TGTTACAGTGGTGGTACTGATGGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTT
TTACGAGGCCCTCTGCTAGGCCACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGAT
GGCACTCTGCGTTTATGGAATACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTG
GATCTAGTGAGCAGTGACCCGAGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATT
CTCACTTTAGAATCCAATGTAGATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATC
ACTGCTCATGAAGACAGGCACATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACA
AGTTTAGCAGTTGATCCCAATGGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGT
ATCCAAGAATTCACAGCTCATCGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCT

>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000379213_chr2_37152351_-_3252nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGGGCCCAATAGGTCAAAACTACAAGATATG
CTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCCAGCAGCTCCAGGCTTCCTGAA
CATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATCATGGGAGCAGATGAAGCCCTT
GAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTATGATATAGCAAACAATAAAGAT
GCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCTTTCCATCCCATTGAGCCTGTT
TTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAGAGCACTTCTCTTGATGTAGAA
CCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAGTGTTACAGTGGTGGTACTGAT
GGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTTTTACGAGGCCCTCTGCTAGGC
CACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGATGGCACTCTGCGTTTATGGAAT
ACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTGGATCTAGTGAGCAGTGACCCG
AGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATTCTCACTTTAGAATCCAATGTA
GATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATCACTGCTCATGAAGACAGGCAC
ATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACAAGTTTAGCAGTTGATCCCAAT
GGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGTATCCAAGAATTCACAGCTCAT
CGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCTGGAGCTGACGCACTGGCTAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000263918_chr2_37152351_-_9179nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGAAAAGGAAGACCAGTGTCTCATGCCTGAA
GCCTGGAATGTGGACCAGGGAGTAATTACCAAACTCAAGGAACAATACAAAAAGGAGAGAAAGGGGAAAAAGGGGGTGAAGAGGCCCAAT
AGGTCAAAACTACAAGATATGCTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCC
AGCAGCTCCAGGCTTCCTGAACATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATC
ATGGGAGCAGATGAAGCCCTTGAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTAT
GATATAGCAAACAATAAAGATGCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCT
TTCCATCCCATTGAGCCTGTTTTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAG
AGCACTTCTCTTGATGTAGAACCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAG
TGTTACAGTGGTGGTACTGATGGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTT
TTACGAGGCCCTCTGCTAGGCCACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGAT
GGCACTCTGCGTTTATGGAATACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTG
GATCTAGTGAGCAGTGACCCGAGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATT
CTCACTTTAGAATCCAATGTAGATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATC
ACTGCTCATGAAGACAGGCACATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACA
AGTTTAGCAGTTGATCCCAATGGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGT
ATCCAAGAATTCACAGCTCATCGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCT
GGAGCTGACGCACTGGCTAAAGTCTTTGTATGACGCAATGCATCATCTTCACCTTCTAGCTGTTTATAAGTAATCAACTGCACACAAGAG
ATACAGAAGACGAGGGCAAGAATCATCTCGTCCTGCCCTTTTGTTCTGCTGAAGGAGCACAGAGAACATTTGTTGAAGTATAGTTTTGCA
ATTCATATACTGTTTTCTAAAACTAAGGTTTGTTCAGGTTGCTGCAAGCTCAGCTGAATCTGTGAGCCTGAGGTCTGTTTCAAATTTCTC
CCCAATAGGCGCCTTTATTTCTGAGGTGGTTCTAATTCGCTAGGCAGGCCTGAGCGAATACAAGTTTAGCTTGTCCCTGTTGAGTAAGTA
GGGCATGCTACAATGGATAATTTAAAAGCTTGATAGCTGGGACTGAATAGAAGAAAACGGGAAACTTAGACCAAGTTCTCCCCTGAGAAA
TCTTGTTAAAACACATTAAGTAGTCAAAATAGTAATCTTTATCATATCTGCCATATTAACCCCTTTGTGTATAATGACCAGGCAGTGTTA
AACTGAGTTTTTAATTTGACTCTCCTTTCAGCTGTTCACATAAAGCACCTGGCAAAGCATTTTACCTGTTAGGGGGAGAAAAATGCAATA
ATATGTTAAATATATTATTATTCAGAAATGCTAGACAAATAGTTTGCAAGCAGATTTCTATATTGTATTACAGTTTTGAAAACAGATTTG
GTATCATTCTAAAGTTTAGCTATCAAGCACTCACCATTGTGAAGAATAGTTGATCGACTCTGCTTTTACTAACAGATTTAACTTATTCAG
GTTTGAAATTCTGTTTATTTTTAAGGGTAAACAGGGCATATCTCTTTAATAATTTCTATTTTAAAATTCACTTTATTCATGTGACATTTA
TAGTACCAGAGTGATTATTTCATACCAATGAAATCTTACTTTTCAGTGACTGAAAAGATAGAATTTATTTGCTAATAATCATTTATCAAC
ACCCACCTAATCATGCTTCAGATGATCTGTGCTCTTTCTTCTTTGTCACGTTCAAGTTATCTGACATCTACCAAGAACAGTTCATAATTA
TTAATAGCCCAAAGAGTATGGTTAACTTCACGCAGCTGCTTTTGCAGAAGCACTAATAAAAACAAATATTTTGTACCCTAGAAGTCCTCT
ATTAATCCCTGTAAGAATCTCCTGGAAACCTGGATGAAAGAGTTTAATGCCAAATATTGGCTAAAAAGTTCTGTCTTTCTCTCTCCCTAT
TCCTCCCCCATTGTTTAATTGAGATATACATGTTTTAATGGGCAGTGGATCAGTATTGTTTCTGGGGAAATCCACACCTTAAAAGGCCAG
GCTTCCCCAGCCCAACTTACCTGTGACCCACCTACATGTGTTCACCTTTTGGGATTCTGAAGACCCTGCTATCTAGACCTAGTCTCCTGT
CATAAAGACATTATTTCTATAGTGGTTTATGTCTCTCTTACTCTTTGTCCCAAATGACAGAGACCAATCTAGAAATTGGAAATAAATTAT
TAACGTCCAACTTTCCACCAAAAAACATATAAATAGGCTCTTAGATTTTAAAAATATTAAATCTATAGATATTTTAACCAATTAAAACAA
TTTCTACATATTCCATTCCCCACATTTTCCATCGTCATAACAATGATGCTTCTCATGATACGTACATCTACTCCTTGAAAAAGTATTCTG
GTGGTGGTGTGGCTAATGATTGACAAATATTTCTGTAAAATTTCTGCCTGTTTGCCTCTAGAATTCTGCATTATACAGGCAAATTTTCTT
TAAAGCTAGAGACTTGTGCTAAATTTGCCTGATTTTCATACAGATATGCTGTAGTAATACAGCTACCTTTTCATTTCATCTTTGTGCTTT
GGTTAACAAGCAGGCTCAAGAGACTGCTTTGTGTAATTAAATGAATTGACCTAAACATGAGCTGTCAGGTGAATACTTAATATTTCCATG
CAGATACAGAATTCCATATTGTGTTCAGTAAATTTCTTTTGGTTCTTCACAGTGAAGAAAGAATGTTTCTAACCTAACATTTGTAGAAGG
ATACTGGAAAATTCCTTCCAGGAAGGAAGGAAGGAAGATGCCATTACTTGGTGTATTTATGATGGATGACCACAAAGCTATTGTTCTACC
AGTTATTAATTACCTTCTAAGATCTTCAGTTACTGCTTTATTAATGTCACTGAAATTCTAAAAACCAGGACATTCTTCCCCCGTTCATTT
TATGCTTCATGGTTGAAATTTTTCTGTCAGTGAGTGGAAAATAACCATGAGATACATAGACTGTAGCGCAAATGGAACTGTTGAAAGTTC
CTTAGAAAGCCAGTGCTGTGGCATTGGAGACTACGGAGAGAGTCTTCTCTACCAGCACTGCATGATCTCAGCCTAGAAATGAGCCAAAGC
TGTCTTCCAACCAGAGTAGCATATACATGTGTCTGACTTTTCCCCTAGCCTGTTGAACATTCAATGAAAATTCACAGAATGAACAAATTC
AATGTTTAAACAGCCATTGAAATGCTTTCATAGTGCTTCATTTGTAAATATTTTGTTTGAAATGTATTGGAATAGTATGAAAATTAGCGG
GAGGTTTGGATCCCTGCCTTATTTTCATATGCTGTGGATACATCTCTGGGAGCTTGCAGCACCCTTCTCAAAACTCAACTGTCATATGGA
GCTCATTTGCTACTCAAACCATAGACAGATTATTTAACAAAAGTGATATAATGACCTTCAGTATTTTTCTATTGAACAAGTTTAACAACT
TTTGCCATTAAACAAATACTTAGTTATGCAAAATATTTCGCTTTTATAATCATTTTAGTTATGACTAAAACGGGGGAAATTGAGCTGCAT
CACTGATGATGAACTTTGTGAGAAATTTTTTTTTTAATCTGACTTTCATTCCTTCAGTATTCTTGCTATAAATTTCTTTTGGAGATAATG
ATGAAGATTTATTTGAAAATGTCTAAAATGTATGTATATTTTATAAATATATATTATATATATTGTAAGAATATATATAATATATAAACT
ATATATATATATATATATATATATATATATATATATATATAAACCATAGGTGCATTTTACTGTTTTGTATTTTCATTTTTGGAGGTAGTA
TACACAGCAGATAATGATGAGTATGATGAGTGTTGTGCTGTTTGCTTTTGCAGTATAATATATAGTTCTAAGTGTTTAAATTACTGTATA
TACAATATTCATTATAGGCTAGCATGCTTGTTTTAAAGACTGTCATTCTAGTGTATTAAAATCTGAATGTAAGAAAACCTGGCTATTCAA
ATGTGAATTGAAAAATATTTTATTCTCAGTACTGAACTATTTCCATTGAACATTCAGACTTTTTAACAAAAACAAATATCATCAAGAAGG
CAATAGCTAGAAAATGAGAGGTGCCTTTAAAAAAAAAAATGCAGCCTTACAGTGAGGATGAAGATTGAGTTTGGGGAGGGGGTGGGAGGG
GGGGCACAGAGAGAGAGAGAGAGTTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCATGCATGCGTGTGTGTGTGTGTGTGT
GTGTTTACCAATCTGTGAAGGTCCTGATTTGTGACCATCAATGTCTTTTTAATGTATCTGCTCAACTTCTAGGACTTCAGGGGACATTTC
ATGCGCTTTGTGCTCTTCTGAGCACCATATATACTTTCCAAGAATTTTGAATGTGAATTCCTAGAAATTTCAGTAGAGAAAACAATAGCT
ATTCTTTAATTATAGTAAAGTTCAGGTAGAAGGAGAAATTATTTGTTCACCAAAATTATGGGATCTCATTAATGTTGGCTAAGTAAATGT
AATTTTTTAAAGGCTCACTTTTTAATACTTCATATATTTCCCTCTTACAAAACAGCATGTCATGAAGTTCTTATGTGGTAAAGATTCAAC
TAGTAAATATTTTTAGGTTAAATACCTGAACTAGTTAAAATTCCACCTAAGAATAGTCTTAAAATATTTAAAAAGCATCTCTCATATCTA
CCTCTTTGTCATTGCTGCCATTTTAACTGAAGCAAATCTTTATGACATCTGAAATGATGGTTGGATGCAATTAAAAAAAAATCTATGTTG
GTGCTTTTCTCAGGCTTTGTCATTTAAGTTATATTGTATTAAGATGTCACAAATCAGACTGAAAGGCTTAGAATTAATTTTGTTTTTCTT
TGAAAGAATTGCTTAAAATTAACCATCAATGTTTTTAGCGAGTGGAGATAATGAATCTTTGGTTGGTGTCTGTCTGTGTGATGTTTTCAA
CCAATAGCCAAATAATTATTGAACTTACATGAAAAAGAGTGCTAAGTATAATTTTATTTAGATTACTTTATTCTTTGAAAGTGACTACAA
GGCTATTAAGTACATAATCATTCATTTTATTTACTCAGAAGTTGCCTCTCCATTACTGTTAACTTGTTTAGTAATTTATATAATTGCAGT
ACTTTTAAGTGTTGGACACTGGGATTCAGGTTGTATACAAAGTAGTAGCTGACGAAAAATATGTATATTTTTGTGAAATGTATCAAGCCC
TAAAGTTCATTTTAGAGAAAGGCCCAGAAAAACGTATCTGTGTTTAAAAACAAAGGACAGGTCATTCGTCAATTTGAATCATTTTTACTT
TTGCCACTACAAACTTTTTAATTGGCAATATCCATCATCCAACTGGATCTTCATGTCAGTGTCAGGGATGCCAGGTTGACAAAGTATTTA
ACAGATCCTTTCAGTTTTTGTTTTGTTTTTTTAATTCTAAAAAAAACAAATGTTAGGCCAAACAGATCCCTAGATCCCACTCATTGATTC
TGGCGGTATTCCTAAAGTGGTGCTTAGGGGGTCAGAATTTTCTGGATCTTTGCTAATCCAAGCTTTAGATTTAATTTAACCAGGACCACA
TGCTTGTCATCTCTCTGATGCAAATTTTCAAAATCATTTTAATTTAGATTCTAATGTCTGCCTGGGTTTTTAACAGGCTGTGAACCAGTG
AGTGCCTTGTTAATGTAGAATGATTTTTCCCCCCTGGGTGGGTGTTAGTTAGCTCCTCTCTGAAAATGTCTCAGAGAATGGTATTTTAAT
TGACTTGTAGAGAGCTGCTAAATTTGTTATTATCAGCAATCAGAAAGTCTTTGGTCTACCACACATCTCCCTCCCTACTATCTCTTCATT
GTTTGGCTGAAGTTTGCCTCTTGTGAGAAAACAATACAACTCCCCTTCTCCACACACTTTTTTTCCAGCCCAGATTAATAGGTATCCCCT
ACCCTAATCCCAACTCTATGATCTAATACCTTTTTTAGGAGGAACCACTTCTTTTTAATATTGAAATCTGCTGGTTACTTTATGTTTTCT
CAAGTTCAGTTGACTAGAGCTGACCACAGGGTGTCATCAATTCAGATTCCTAAATAACCCTTTCTCTCCACACCCAGTCCTCCAGCTGGT
GAGCCCTGGGCCAGATTGTTTGATCTTCAGGTATTTTAAATTTTAGTTACATCAATTAATGTAAATTAATCCAAATGCTAATTTTTGTGG
TGCAAGAAGTTTCTTATGTAAATTCAGGGTATGGATAAGCTAATTAAGATATCCATCTTTGGTGGCTCTAAGTGTATTATTTGTTTTTAA
ATAAAGTGTACAAATATAGATAACATGCTATAGGTGTCTCATGAATTGGAATATTTGTCAGATTTGGGATCTAGCTGTGGCTTTACAGTA

>In-frame_EIF2AK2_ENST00000405334_chr2_37341874_-_STRN_ENST00000379213_chr2_37152351_-_4379nt
ATGGCTGGTGATCTTTCAGCAGGTTTCTTCATGGAGGAACTTAATACATACCGTCAGAAGCAGGGAGTAGTACTTAAATATCAAGAACTG
CCTAATTCAGGACCTCCACATGATAGGAGGTTTACATTTCAAGTTATAATAGATGGAAGAGAATTTCCAGAAGGTGAAGGTAGATCAAAG
AAGGAAGCAAAAAATGCCGCAGCCAAATTAGCTGTTGAGATACTTAATAAGGAAAAGAAGGCAGTTAGTCCTTTATTATTGACAACAACG
AATTCTTCAGAAGGATTATCCATGGGGAATTACATAGGCCTTATCAATAGAATTGCCCAGAAGAAAAGACTAACTGTAAATTATGAACAG
TGTGCATCGGGGGTGCATGGGCCAGAAGGATTTCATTATAAATGCAAAATGGGACAGAAAGAATATAGTATTGGTACAGGTTCTACTAAA
CAGGAAGCAAAACAATTGGCCGCTAAACTTGCATATCTTCAGATATTATCAGAAGAAACCTCAGTGAAATCTGACTACCTGTCCTCTGGT
TCTTTTGCTACTACGTGTGAGTCCCAAAGCAACTCTTTAGTGACCAGCACACTCGCTTCTGAATCATCATCTGAAGGTGACTTCTCAGCA
GATACATCAGAGATAAATTCTAACAGTGACAGTTTAAACAGTTCTTCGTTGCTTATGAATGGTCTCAGAAATAATCAAAGGAAGGCAAAA
AGATCTTTGGCACCCAGATTTGACCTTCCTGACATGAAAGAAACAAAGTATACTGTGGACAAGAGGAAGGCGGAGCGTGAAGTAAAAGCA
TTGGCAAAACTTGATCATGTAAATATTGTTCACTACAATGGCTGTTGGGATGGATTTGATTATGATCCTGAGACCAGTGATGATTCTCTT
GAGAGCAGTGATTATGATCCTGAGAACAGCAAAAATAGTTCAAGGTCAAAGACTAAGTGCCTTTTCATCCAAATGGAATTCTGTGATAAA
GGGACCTTGGAACAATGGATTGAAAAAAGAAGAGGCGAGAAACTAGACAAAGTTTTGGCTTTGGAACTCTTTGAACAAATAACAAAAGGG
GTGGATTATATACATTCAAAAAAATTAATTCATAGAGATCTTAAGCCAAGTAATATATTCTTAGTAGATACAAAACAAGTAAAGATTGGA
GACTTTGGACTTGTAACATCTCTGAAAAATGATGGAAAGCGAACAAGGAGTAAGGGAACTTTGCGATACATGAGCCCAGAACAGGCCCAG
ATTGCCTTCCTGCAGGGAGAAAGGAAGGGCCAAGAAAATTTGAAGAAGGATCTTGTGAGGAGGATCAAAATGTTGGAGTATGCTCTTAAA
CAGGAAAGAGCCAAATACCACAAGTTGAAATACGGGACAGAATTGAATCAGGGAGATATGAAGCCTCCAAGCTATGATTCTGATGAAGGT
AATGAAACAGAAGTGCAGCCACAACAAAACAGCCAGTTAATGTGGAAACAAGGTCGACAACTACTCAGACAGTATCTACAGGAGGTGGGT
TATACAGATACTATTCTAGATGTGAAATCTAAACGAGTGCGAGCTTTGTTGGGCTTTTCAAGTGATGTCACGGACAGGGAAGATGACAAA
AATCAGGACTCAGTTGTAAATGGCACAGAGGCTGAAGTTAAAGAGACAGCAATGATTGCAAAATCTGAGTTAACAGATTCTGCCTCCGTG
CTGGATAATTTCAAATTCCTTGAAAGTGCAGCTGCAGATTTCAGTGATGAAGATGAAGATGATGATGTTGATGGAAGAGAGAAAAGCGTC
ATTGATACTTCAACAATTGTTAGGAAAAAAGCATTGCCTGACAGCGGTGAAGATCGAGATACAAAAGAAGCTCTAAAGGAGTTTGACTTC
TTGGTTACATCAGAGGAAGGAGACAATGAATCTAGAAGTGCAGGCGATGGAACAGACTGGGGGCCCAATAGGTCAAAACTACAAGATATG
CTTGCTAATTTGAGAGATGTTGATGAACTTCCTTCATTGCAGCCATCTGTGGGTTCACCTTCCAGACCCAGCAGCTCCAGGCTTCCTGAA
CATGAAATTAATAGGGCAGATGAAGTGGAAGCATTGACATTTCCTCCTTCTTCTGGAAAGTCATTCATCATGGGAGCAGATGAAGCCCTT
GAAAGTGAACTGGGACTTGGAGAACTAGCAGGCCTTACGGTGGCCAATGAAGCAGACTCACTAACTTATGATATAGCAAACAATAAAGAT
GCATTGAGGAAGACATGGAACCCTAAGTTTACATTGAGAAGTCACTTTGATGGCATCCGAGCCCTTGCTTTCCATCCCATTGAGCCTGTT
TTGATAACAGCATCAGAGGATCACACATTAAAAATGTGGAATTTACAGAAAACAGCCCCAGCCAAAAAGAGCACTTCTCTTGATGTAGAA
CCTATCTATACATTCAGAGCCCATAAAGGTCCAGTGCTTTGTGTGGTAATGAGCAGCAATGGTGAGCAGTGTTACAGTGGTGGTACTGAT
GGACTGATCCAGGGCTGGAATACCACTAATCCCAACATCGACCCCTATGATTCTTATGATCCTTCTGTTTTACGAGGCCCTCTGCTAGGC
CACACGGATGCAGTCTGGGGTTTGGCTTATAGTGCAGCACATCAGCGTTTGTTGTCCTGTTCAGCAGATGGCACTCTGCGTTTATGGAAT
ACAACTGAGGTTGCTCCAGCACTAAGTGTATTTAATGATACTAAAGAACTGGGAATCCCTGCCTCTGTGGATCTAGTGAGCAGTGACCCG
AGCCATATGGTAGCATCATTCAGCAAGGGATATACAAGCATTTTTAACATGGAAACACAACAACGCATTCTCACTTTAGAATCCAATGTA
GATACAACAGCCAACTCTTCCTGCCAAATAAATAGAGTCATCAGTCATCCTACTCTTCCGATCAGCATCACTGCTCATGAAGACAGGCAC
ATCAAATTCTATGATAACAATACAGGCAAACTGATCCACTCGATGGTAGCCCACCTAGAAGCTGTTACAAGTTTAGCAGTTGATCCCAAT
GGCCTTTACTTGATGTCTGGCAGTCATGACTGTTCAATACGTTTATGGAATCTAGAAAGTAAGACGTGTATCCAAGAATTCACAGCTCAT
CGAAAAAAGTTTGAAGAATCGATTCATGATGTAGCTTTCCACCCATCCAAATGCTATATAGCCAGTGCTGGAGCTGACGCACTGGCTAAA
GTCTTTGTATGACGCAATGCATCATCTTCACCTTCTAGCTGTTTATAAGTAATCAACTGCACACAAGAGATACAGAAGACGAGGGCAAGA
ATCATCTCGTCCTGCCCTTTTGTTCTGCTGAAGGAGCACAGAGAACATTTGTTGAAGTATAGTTTTGCAATTCATATACTGTTTTCTAAA
ACTAAGGTTTGTTCAGGTTGCTGCAAGCTCAGCTGAATCTGTGAGCCTGAGGTCTGTTTCAAATTTCTCCCCAATAGGCGCCTTTATTTC
TGAGGTGGTTCTAATTCGCTAGGCAGGCCTGAGCGAATACAAGTTTAGCTTGTCCCTGTTGAGTAAGTAGGGCATGCTACAATGGATAAT
TTAAAAGCTTGATAGCTGGGACTGAATAGAAGAAAACGGGAAACTTAGACCAAGTTCTCCCCTGAGAAATCTTGTTAAAACACATTAAGT
AGTCAAAATAGTAATCTTTATCATATCTGCCATATTAACCCCTTTGTGTATAATGACCAGGCAGTGTTAAACTGAGTTTTTAATTTGACT
CTCCTTTCAGCTGTTCACATAAAGCACCTGGCAAAGCATTTTACCTGTTAGGGGGAGAAAAATGCAATAATATGTTAAATATATTATTAT
TCAGAAATGCTAGACAAATAGTTTGCAAGCAGATTTCTATATTGTATTACAGTTTTGAAAACAGATTTGGTATCATTCTAAAGTTTAGCT
ATCAAGCACTCACCATTGTGAAGAATAGTTGATCGACTCTGCTTTTACTAACAGATTTAACTTATTCAGGTTTGAAATTCTGTTTATTTT
TAAGGGTAAACAGGGCATATCTCTTTAATAATTTCTATTTTAAAATTCACTTTATTCATGTGACATTTATAGTACCAGAGTGATTATTTC
ATACCAATGAAATCTTACTTTTCAGTGACTGAAAAGATAGAATTTATTTGCTAATAATCATTTATCAACACCCACCTAATCATGCTTCAG
ATGATCTGTGCTCTTTCTTCTTTGTCACGTTCAAGTTATCTGACATCTACCAAGAACAGTTCATAATTATTAATAGCCCAAAGAGTATGG


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FusionGenePPI for EIF2AK2_STRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF2AK2DBNL, FANCC, PRKRIP1, STAT1, PPP1CA, PRKRA, TP53, ILF3, METAP2, DNAJC3, PPP2R5A, ILF2, EIF2AK2, TARBP2, MAP3K5, CHUK, IKBKB, HIST2H2AC, PDGFRB, STAT3, EIF2S1, DHX58, CCNA2, DHX9, DICER1, EDC4, STAU2, ZNF346, STAU1, CCDC124, CDK3, EBNA1BP2, FARSB, FTSJ3, GLTSCR2, IFRD1, NOC3L, PPP1CC, DHX30, EIF6, FARSA, GNL3, GTPBP4, HIST1H1C, HNRNPC, HNRNPCL1, KCTD17, LYAR, MOV10, NOP2, PABPC4, PURA, SSB, TOLLIP, TOP1, XRN2, MAVS, HDGF, ELAVL1, MAP3K7, ISG15, CUL3, CAND1, ATP6V1F, JAK1, TYK2, HSP90AA1, IL7R, NPM1, EIF2A, PTGES3, HECW2, IGF2BP3, IGF2BP2, EGFR, TRAF5, TRAF6, TRAF2, CYP1A1, NTRK1, IFI16, SCARB2, RPL10, ELMSAN1, CDCA5, CHMP4B, MACROD1, MCM2, CDC37, PRKRIR, HIST1H2AB, MECP2, GPX7, IQCF1, PTEN, RPL6, RPLP0, RPS2, RPS3A, LMNA, COX15, DLD, DLSTSTRNSTK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN3, PPP2R1B, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, CCT6B, TRAF3IP3, PPP2CB, ZRANB1, ELAVL1, LNX1, APC, TJP1, DDX1, DYNC1H1, CPSF6, EIF2S1, SF3B5, BRCA1, ECT2, PAXIP1, STK3, STK4, TFIP11, RINT1, PCOLCE2, LYPD3, NR1H3, PPP2R2C, RASSF3, PGAM5, NTRK1, HSPB1, DYNLL1, MAP4K4, EEF1E1, BAG2, SLC43A3, AHNAK, PRDM14, TNFRSF1A, NHSL2, PSMC5, PLP1, ZNF550, SNX24, LRRCC1, ZNF331, PRPF19, SPINK2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF2AK2_STRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF2AK2_STRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEIF2AK2C0021400Influenza1CTD_human
HgeneEIF2AK2C0033578Prostatic Neoplasms1CTD_human
HgeneEIF2AK2C0038220Status Epilepticus1CTD_human