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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 112

FusionGeneSummary for ABCA5_APOL3

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCA5_APOL3
Fusion gene ID: 112
HgeneTgene
Gene symbol

ABCA5

APOL3

Gene ID

23461

80833

Gene nameATP binding cassette subfamily A member 5apolipoprotein L3
SynonymsABC13|EST90625APOLIII|CG121|CG12_1|apoL-III
Cytomap

17q24.3

22q12.3

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family A member 5ATP-binding cassette A5ATP-binding cassette, sub-family A (ABC1), member 5apolipoprotein L3TNF-inducible protein CG12-1apolipoprotein L, 3apolipoprotein L-IIIapolipoprotein L-III splice variant alphaapolipoprotein L-III splice variant beta
Modification date2018052320180523
UniProtAcc

Q8WWZ7

O95236

Ensembl transtripts involved in fusion geneENST00000392676, ENST00000392677, 
ENST00000588877, ENST00000589609, 
ENST00000397293, ENST00000424878, 
ENST00000349314, ENST00000361710, 
ENST00000397287, ENST00000487423, 
Fusion gene scores* DoF score6 X 6 X 4=1446 X 6 X 2=72
# samples 66
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCA5 [Title/Abstract] AND APOL3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV335051ABCA5chr17

67251984

+APOL3chr22

36555642

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000392676ENST00000397293ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392676ENST00000424878ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392676ENST00000349314ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392676ENST00000361710ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392676ENST00000397287ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392676ENST00000487423ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000397293ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000424878ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000349314ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000361710ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000397287ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000392677ENST00000487423ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000397293ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000424878ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000349314ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000361710ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000397287ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000588877ENST00000487423ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000397293ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000424878ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000349314ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000361710ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000397287ABCA5chr17

67251984

+APOL3chr22

36555642

-
intron-intronENST00000589609ENST00000487423ABCA5chr17

67251984

+APOL3chr22

36555642

-

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FusionProtFeatures for ABCA5_APOL3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA5

Q8WWZ7

APOL3

O95236

May play a role in the processing of autolysosomes.{ECO:0000250}. May affect the movement of lipids in the cytoplasm orallow the binding of lipids to organelles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABCA5_APOL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABCA5_APOL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABCA5_APOL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABCA5_APOL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCA5C0009404Colorectal Neoplasms1CTD_human