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Fusion gene ID: 1115 |
FusionGeneSummary for AGO1_ABCC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGO1_ABCC3 | Fusion gene ID: 1115 | Hgene | Tgene | Gene symbol | AGO1 | ABCC3 | Gene ID | 26523 | 8714 |
| Gene name | argonaute 1, RISC catalytic component | ATP binding cassette subfamily C member 3 | |
| Synonyms | EIF2C|EIF2C1|GERP95|Q99|hAgo1 | ABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2 | |
| Cytomap | 1p34.3 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein argonaute-1Golgi Endoplasmic Reticulum protein 95 kDaargonaute RISC catalytic component 1argonaute1eIF-2C 1eIF2C 1eukaryotic translation initiation factor 2C, 1putative RNA-binding protein Q99 | canalicular multispecific organic anion transporter 2ATP-binding cassette sub-family C member 3ATP-binding cassette, sub-family C (CFTR/MRP), member 3canicular multispecific organic anion transportermulti-specific organic anion transporter Dmultidrug | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UL18 | O15438 | |
| Ensembl transtripts involved in fusion gene | ENST00000373206, ENST00000373204, | ENST00000285238, ENST00000515707, ENST00000427699, ENST00000510891, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 8 X 3=168 |
| # samples | 3 | 11 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(11/168*10)=-0.610957709254101 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGO1 [Title/Abstract] AND ABCC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AGO1 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 18771919 |
| Hgene | AGO1 | GO:0010501 | RNA secondary structure unwinding | 19966796 |
| Hgene | AGO1 | GO:0031054 | pre-miRNA processing | 19966796 |
| Hgene | AGO1 | GO:0035278 | miRNA mediated inhibition of translation | 18771919 |
| Hgene | AGO1 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA | 15260970 |
| Hgene | AGO1 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 19966796 |
| Hgene | AGO1 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA | 15260970 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG954174 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - | ||
| ChiTaRS3.1 | BG954173 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000373206 | ENST00000285238 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373206 | ENST00000515707 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373206 | ENST00000427699 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373206 | ENST00000510891 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373204 | ENST00000285238 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373204 | ENST00000515707 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373204 | ENST00000427699 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
| 3UTR-intron | ENST00000373204 | ENST00000510891 | AGO1 | chr1 | 36385255 | - | ABCC3 | chr17 | 48757085 | - |
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FusionProtFeatures for AGO1_ABCC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGO1 | ABCC3 |
| Required for RNA-mediated gene silencing (RNAi). Bindsto short RNAs such as microRNAs (miRNAs) or short interfering RNAs(siRNAs), and represses the translation of mRNAs which arecomplementary to them. Lacks endonuclease activity and does notappear to cleave target mRNAs. Also required for transcriptionalgene silencing (TGS) of promoter regions which are complementaryto bound short antigene RNAs (agRNAs).{ECO:0000269|PubMed:16289642, ECO:0000269|PubMed:16936728,ECO:0000269|PubMed:18771919}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AGO1_ABCC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AGO1_ABCC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGO1_ABCC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGO1_ABCC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AGO1 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | AGO1 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | AGO1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Hgene | AGO1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | ABCC3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | ABCC3 | C0008370 | Cholestasis | 1 | CTD_human |
| Tgene | ABCC3 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
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