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Fusion gene ID: 11146 |
FusionGeneSummary for EHD1_ADRBK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EHD1_ADRBK2 | Fusion gene ID: 11146 | Hgene | Tgene | Gene symbol | EHD1 | ADRBK2 | Gene ID | 10938 | 157 |
| Gene name | EH domain containing 1 | G protein-coupled receptor kinase 3 | |
| Synonyms | H-PAST|HPAST1|PAST|PAST1 | ADRBK2|BARK2 | |
| Cytomap | 11q13.1 | 22q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | EH domain-containing protein 1PAST homolog 1testilin | beta-adrenergic receptor kinase 2adrenergic, beta, receptor kinase 2beta-ARK-2 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9H4M9 | ||
| Ensembl transtripts involved in fusion gene | ENST00000320631, ENST00000359393, ENST00000488711, | ENST00000324198, | |
| Fusion gene scores | * DoF score | 5 X 5 X 6=150 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: EHD1 [Title/Abstract] AND ADRBK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ADRBK2 | GO:0031623 | receptor internalization | 20074556 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-HT-7686-01A | EHD1 | chr11 | 64627396 | - | ADRBK2 | chr22 | 26057543 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000320631 | ENST00000324198 | EHD1 | chr11 | 64627396 | - | ADRBK2 | chr22 | 26057543 | + |
| Frame-shift | ENST00000359393 | ENST00000324198 | EHD1 | chr11 | 64627396 | - | ADRBK2 | chr22 | 26057543 | + |
| intron-3CDS | ENST00000488711 | ENST00000324198 | EHD1 | chr11 | 64627396 | - | ADRBK2 | chr22 | 26057543 | + |
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FusionProtFeatures for EHD1_ADRBK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EHD1 | ADRBK2 |
| ATP- and membrane-binding protein that controls membranereorganization/tubulation upon ATP hydrolysis. In vitro causesvesiculation of endocytic membranes (PubMed:24019528). Acts inearly endocytic membrane fusion and membrane trafficking ofrecycling endosomes (PubMed:15020713, PubMed:17233914,PubMed:20801876). Recruited to endosomal membranes upon nervegrowth factor stimulation, indirectly regulates neurite outgrowth(By similarity). Plays a role in myoblast fusion (By similarity).Involved in the unidirectional retrograde dendritic transport ofendocytosed BACE1 and in efficient sorting of BACE1 to axonsimplicating a function in neuronal APP processing (By similarity).Plays a role in the formation of the ciliary vesicle (CV), anearly step in cilium biogenesis. Proposed to be required for thefusion of distal appendage vesicles (DAVs) to form the CV byrecruiting SNARE complex component SNAP29. Is required forrecruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss ofCCP110 form the mother centriole essential for the maturation ofthe basal body during ciliogenesis (PubMed:25686250).{ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4,ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528,ECO:0000269|PubMed:25686250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 198_227 | 305 | 535 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 198_227 | 305 | 535 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 55_286 | 305 | 535 | Domain | Dynamin-type G |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 55_286 | 305 | 535 | Domain | Dynamin-type G |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 153_156 | 305 | 535 | Region | G3 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 219_222 | 305 | 535 | Region | G4 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 243_243 | 305 | 535 | Region | G5 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 65_72 | 305 | 535 | Region | G1 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 91_92 | 305 | 535 | Region | G2 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 153_156 | 305 | 535 | Region | G3 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 219_222 | 305 | 535 | Region | G4 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 243_243 | 305 | 535 | Region | G5 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 65_72 | 305 | 535 | Region | G1 motif |
| Hgene | EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 91_92 | 305 | 535 | Region | G2 motif |
| Tgene | >ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 191_453 | 88 | 689 | Domain | Protein kinase |
| Tgene | >ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 454_521 | 88 | 689 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 558_652 | 88 | 689 | Domain | PH |
| Tgene | >ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 197_205 | 88 | 689 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 489_500 | 305 | 535 | Calcium binding | Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269 |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 489_500 | 305 | 535 | Calcium binding | Ontology_term=ECO:0000244,ECO:0000244,ECO:0000269 |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 444_532 | 305 | 535 | Domain | EH |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000320631 | - | 3 | 5 | 476_511 | 305 | 535 | Domain | EF-hand |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 444_532 | 305 | 535 | Domain | EH |
| Hgene | >EHD1 | chr11:64627396 | chr22:26057543 | ENST00000359393 | - | 5 | 7 | 476_511 | 305 | 535 | Domain | EF-hand |
| Tgene | ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 54_175 | 88 | 689 | Domain | RGS |
| Tgene | ADRBK2 | chr11:64627396 | chr22:26057543 | ENST00000324198 | + | 2 | 21 | 1_190 | 88 | 689 | Region | Note=N-terminal |
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FusionGeneSequence for EHD1_ADRBK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EHD1_ENST00000320631_chr11_64627396_-_ADRBK2_ENST00000324198_chr22_26057543_+_906aa MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGP EPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAE RVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKL FEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTS TLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE TLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANI LLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVEL PDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQ ELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGE GESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EHD1_ENST00000320631_chr11_64627396_-_ADRBK2_ENST00000324198_chr22_26057543_+_2718nt ATGTTCAGCTGGGTCAGCAAGGATGCCCGCCGCAAGAAGGAGCCGGAGCTCTTCCAGACGGTGGCTGAGGGGCTGCGGCAGCTGTACGCG CAGAAGCTGCTACCCCTGGAGGAGCACTACCGCTTCCACGAGTTCCACTCGCCCGCGCTGGAGGACGCTGACTTCGACAACAAGCCTATG GTGCTCCTCGTGGGGCAGTACAGCACGGGCAAGACCACCTTCATCCGACACCTGATCGAGCAGGACTTCCCGGGGATGCGCATCGGGCCC GAGCCCACCACCGACTCCTTCATCGCCGTCATGCACGGCCCCACTGAGGGCGTGGTGCCGGGCAACGCGCTCGTGGTGGACCCGCGGCGC CCCTTCCGCAAGCTCAACGCGTTTGGCAACGCTTTCCTCAACAGGTTCATGTGTGCCCAGCTGCCCAACCCCGTCCTGGACAGCATCAGC ATCATCGACACCCCCGGGATCCTGTCTGGAGAGAAGCAGCGGATCAGCAGAGGCTATGACTTTGCAGCCGTCCTGGAGTGGTTCGCGGAG CGTGTGGACCGCATCATCCTGCTCTTCGACGCCCACAAGCTGGACATCTCCGATGAGTTCTCGGAAGTGATCAAGGCTCTGAAGAACCAT GAGGACAAGATCCGCGTGGTGCTGAACAAGGCAGACCAGATCGAGACGCAGCAGCTGATGCGGGTGTACGGGGCCCTCATGTGGTCCCTG GGCAAGATCATCAACACCCCCGAGGTGGTCAGGGTCTACATCGGCTCCTTCTGGTCCCACCCGCTCCTCATCCCCGACAACCGCAAGCTC TTTGAGGCCGAGGAGCAGGACCTCTTCAAGGACATCCAGTCACTGCCCCGAAACGCCGCCCTCAGGAAGCTCAATGACCTGATCAAGCGG GCACGGCTGGCCAAGATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATC ATGAAGGAACTTCTTTCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCA ACTCTTTTTCAGCCATACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGA TTTTGTCAGTGGAAAAACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGG GAAGTTTATGGTTGCAGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAA ACATTAGCCTTAAATGAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACC CCAGATAAACTCTGCTTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAG ATGCGGTTTTATGCCACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATT CTCTTGGATGAACATGGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTTGGCACC CATGGGTACATGGCTCCCGAGGTGCTGCAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAA CTTCTGAGAGGTCACAGCCCTTTCAGACAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTT CCAGACACCTTCTCTCCTGAACTGAAGTCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGC TCACAGGAAGTAAAAGAGCACAGCTTTTTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCC CGGGGAGAAGTCAATGCTGCTGATGCCTTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAA GAACTCTACAAGAACTTCCCTTTGGTCATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACA GATAAAATCGAGGCCAGGAAGAGAGCTAAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGG TACATGCTGAAACTGGGAAACCCATTTCTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAG GGAGAGTCCCGGCAAAATTTACTGACAATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGA ATAAAAGGAGGGAAACAATTTGTCTTGCAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAG GCCCAGCGGCTATTGCGTCGTGCCCCGAAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EHD1_ENST00000320631_chr11_64627396_-_ADRBK2_ENST00000324198_chr22_26057543_+_9817nt CCCTACCGCCCCCAATTCCGCCCTGCCCCCGCCGCGGCGGCGCTAGCCGCCACTGAGGGACCGACCCTATAAAGGCCGCTCCGCGAGGGG TGCGCAGCATTCGGCAGAGGGCGCTTCGACGGGCTGGGCTGTGCGCCTGCGCAGTGTGGGTCGCTCCCGATTCCCTGCCCCGGCCGGCCC CGCCTCGGCTCCGCACCCTCGCCCCGCTCTCAGCCGCCGCTCTGCCCCGCAGCAGCCAGCCCCGTGTCCGGCAGTATGTTCAGCTGGGTC AGCAAGGATGCCCGCCGCAAGAAGGAGCCGGAGCTCTTCCAGACGGTGGCTGAGGGGCTGCGGCAGCTGTACGCGCAGAAGCTGCTACCC CTGGAGGAGCACTACCGCTTCCACGAGTTCCACTCGCCCGCGCTGGAGGACGCTGACTTCGACAACAAGCCTATGGTGCTCCTCGTGGGG CAGTACAGCACGGGCAAGACCACCTTCATCCGACACCTGATCGAGCAGGACTTCCCGGGGATGCGCATCGGGCCCGAGCCCACCACCGAC TCCTTCATCGCCGTCATGCACGGCCCCACTGAGGGCGTGGTGCCGGGCAACGCGCTCGTGGTGGACCCGCGGCGCCCCTTCCGCAAGCTC AACGCGTTTGGCAACGCTTTCCTCAACAGGTTCATGTGTGCCCAGCTGCCCAACCCCGTCCTGGACAGCATCAGCATCATCGACACCCCC GGGATCCTGTCTGGAGAGAAGCAGCGGATCAGCAGAGGCTATGACTTTGCAGCCGTCCTGGAGTGGTTCGCGGAGCGTGTGGACCGCATC ATCCTGCTCTTCGACGCCCACAAGCTGGACATCTCCGATGAGTTCTCGGAAGTGATCAAGGCTCTGAAGAACCATGAGGACAAGATCCGC GTGGTGCTGAACAAGGCAGACCAGATCGAGACGCAGCAGCTGATGCGGGTGTACGGGGCCCTCATGTGGTCCCTGGGCAAGATCATCAAC ACCCCCGAGGTGGTCAGGGTCTACATCGGCTCCTTCTGGTCCCACCCGCTCCTCATCCCCGACAACCGCAAGCTCTTTGAGGCCGAGGAG CAGGACCTCTTCAAGGACATCCAGTCACTGCCCCGAAACGCCGCCCTCAGGAAGCTCAATGACCTGATCAAGCGGGCACGGCTGGCCAAG ATAAAGGAATATGAAAAACTTGATAATGAGGAAGACCGCCTTTGCAGAAGTCGACAAATTTATGATGCCTACATCATGAAGGAACTTCTT TCCTGTTCACATCCTTTCTCAAAGCAAGCTGTAGAACACGTACAAAGTCATTTATCCAAGAAACAAGTGACATCAACTCTTTTTCAGCCA TACATAGAAGAAATTTGTGAAAGCCTTCGAGGTGACATTTTTCAAAAATTTATGGAAAGTGACAAGTTCACTAGATTTTGTCAGTGGAAA AACGTTGAATTAAATATCCATTTGACCATGAATGAGTTCAGTGTGCATAGGATTATTGGACGAGGAGGATTCGGGGAAGTTTATGGTTGC AGGAAAGCAGACACTGGAAAAATGTATGCAATGAAATGCTTAGATAAGAAGAGGATCAAAATGAAACAAGGAGAAACATTAGCCTTAAAT GAAAGAATCATGTTGTCTCTTGTCAGCACAGGAGACTGTCCTTTCATTGTATGTATGACCTATGCCTTCCATACCCCAGATAAACTCTGC TTCATCCTGGATCTGATGAACGGGGGCGATTTGCACTACCACCTTTCACAACACGGTGTGTTCTCTGAGAAGGAGATGCGGTTTTATGCC ACTGAAATCATTCTGGGTCTGGAACACATGCACAATCGGTTTGTTGTCTACAGAGATTTGAAGCCAGCAAATATTCTCTTGGATGAACAT GGACACGCAAGAATATCAGATCTTGGTCTTGCCTGCGATTTTTCCAAAAAGAAGCCTCATGCGAGTGTTGGCACCCATGGGTACATGGCT CCCGAGGTGCTGCAGAAGGGGACGGCCTATGACAGCAGTGCCGACTGGTTCTCCCTGGGCTGCATGCTTTTCAAACTTCTGAGAGGTCAC AGCCCTTTCAGACAACATAAAACCAAAGACAAGCATGAAATTGACCGAATGACACTCACCGTGAATGTGGAACTTCCAGACACCTTCTCT CCTGAACTGAAGTCCCTTTTGGAGGGCTTGCTTCAGCGAGACGTTAGCAAGCGGCTGGGCTGTCACGGAGGCGGCTCACAGGAAGTAAAA GAGCACAGCTTTTTCAAAGGTGTTGACTGGCAGCATGTCTACTTACAAAAGTACCCACCACCCTTGATTCCTCCCCGGGGAGAAGTCAAT GCTGCTGATGCCTTTGATATTGGCTCATTTGATGAAGAGGATACCAAAGGGATTAAGCTACTTGATTGCGACCAAGAACTCTACAAGAAC TTCCCTTTGGTCATCTCTGAACGCTGGCAGCAAGAAGTAACGGAAACAGTTTATGAAGCAGTAAATGCAGACACAGATAAAATCGAGGCC AGGAAGAGAGCTAAAAATAAGCAACTTGGCCACGAAGAAGATTACGCTCTGGGGAAGGACTGTATTATGCACGGGTACATGCTGAAACTG GGAAACCCATTTCTGACTCAGTGGCAGCGTCGCTATTTTTACCTCTTTCCAAATAGACTTGAATGGAGAGGAGAGGGAGAGTCCCGGCAA AATTTACTGACAATGGAACAGATTCTCTCTGTGGAAGAAACTCAAATTAAAGACAAAAAATGCATTTTGTTCAGAATAAAAGGAGGGAAA CAATTTGTCTTGCAATGTGAGAGTGATCCAGAGTTTGTGCAGTGGAAGAAAGAGTTGAACGAAACCTTCAAGGAGGCCCAGCGGCTATTG CGTCGTGCCCCGAAGTTCCTCAACAAACCTCGGTCAGGTACTGTGGAGCTCCCAAAGCCATCCCTCTGTCACAGAAACAGCAACGGCCTC TAGCACCCAGAAACAGGGAGGGTCCTCGAGGAGGACACACCAGGGTCTCAGCCTTTTGGGGTGAACGAGGATGAGGCATCTGATCTATTC GCTACCGGGACTCCTCCAGGCTCCCGAGAGGAGTCGGGACCCTTCGGCTTGGGGTCAGCTCAGCTCCCTGCCTTGTCACATTTGTCTGCA TTAGAAACTACTGAAGAAATAAAAGTTCTTTTTCTTTGCTACACACTTTGGTACCTATGAACCTAGAACTTGAAGTGACTCCTACTTATC ACGTAAATTTTTATGTCTGATATCAAACACATCTTAGACTCCCCAGAATGGAATTTAAAGATGTTCAGTGTTGGGTAACAGATTGCCCTA AGCATTGCCACATATTCTGTCTAGTCACTGCTGATTTTCTATGTCTTTGCTCCATACTGCTGGGGGATGGGAGAGCCACAGTGTGTTTCT TTTGTGCACTTCGCAACTGACTTCTTGTCCTGGGGTTAAAAGTTGAAGATATTTTCTGATGATATTAAAAGTTGAAGATATTTCTGCACT TGGGCCCTCCTCTGGGAGCCGCACCCACATGACTGCCCTGCCTCTGACCAGTCTGTTCCGGGGCCCCCTCAGCCAGGTGGGAATGACGGA CACGTACTATCCAAGTGTATGGGATTAACTAATCATTGAAGGCATTCATCCGTCCATCATTGGAAAGATTTACAGTGATTCTGAAGGACA GGCCGTGGAGTTTTAGGTTTCAGGGGCAAGAGCAGTTTTCAAAAGTCTTTGAGTCCAGTGTGCACGAGTCGACAAGCAGTACCTGGCATG CAGGAGCACTCATGGGTGAGTCCGTCTCAGGTCTCGACAATTAGCAGTTGTGTGACAGTCATTCTGGTTCCTTCTGCCTGACCCTGGGAG ACATATCAGTAATGGATGTACAAAAGCAGGTCTGTTTTATGTCTTAGTATAATTTCAGATGAATTGTATTGAAAAAATGCTGAGGAATGA ATGTGTCAAAATGGGTTAACTGTGTATATTGACTTTCATGTCGTCATGCATCTGTCATGAATGAATGATACTTTGCACTGGGCTGTACGA CAGTGAGGACCTTAGGGCATGAAGCCTTTTTCCTGGTCCCAGCAGCATCTGCCCTGTGAAGTTTGTTTTCTCCCACTGCCTCCAGGCCCC ACTGATACCCCCAAATAGATGCTGGGTTATGAGAACCAGCGAAATCCCCCATGTCATCAGTCTTAAAAAAAAAATTTTACAAATCCACGT ATTTGTCCCATTCTTGGAGTAGTTTTAGTGTATGTCTTTACATTAACTACTAACAGTATAAATAACTTGACATCGTAATTGTCTGCATCC TGTCCTTGATATTTTTAGCAGTTCCAAATCTTTGTTTTTGTATTTGTTTGCTGTGTTCATGGGCAAAGTAAGTACTTTTTAATGCAGTTA TTTTGAGAGTTTGGAAGATAATTACCAAAAGGGTCCATTATTTCATAAGAGTTACTTTGCAAAAAAAAAAATGTGGGTTTTTTTTTTTGT CTATCTCAACTACTAGTTGGGGTTTAAATTAACATACATTTTCTACTATCTGTTATTTCCAGTGTGGGAGGAGGGATGTACTACTTACAT GCATTCTCCTTATTTAAAAAGGAAGAATAGTATTCAAATTCTGTTGAAACACACACACACACACACACACACACACACACACACTCCAGA AGCAGAAAAGCCATTGTTCTTAAAGAGTGAATGTCTTCCCAGCCCTGGTTAATTATAGCTGTGACTGATGCCGTTCCCGTCTGCATCTCA AGCTCATAGGTTCTCAGCATGTGCAGTTGAGGATGCGCTGGGCCTCATGCCTGTTCTAGATCTCCAGGATAAAGGGCCTGCTGTTGACTC CACCAGGGTCTGGGCTTAGCGTCTAATATCTCGTACCTAGGGCGTGAGCTGCACAAACGTGTTCAGAAAGATTATTCAACTTTCCCATAC TTGTTCTAAAATTGAGCTGATCCGCATCTCTTTCAAAAACTAGAATTTCTGCTCTAAGAATAGAACATAAGGCTCCACTCCCTTTTAGAA AAGATATATGAATTGGAAAATGCTCTGAAAGTCCTTTTGCTTCAAACAAAAGTGTAAACTTTTACACTTCCCCAACTCACATTTGATTTG TAATGATATGGTTGAGAAGTACATCTAGATGTCATTTATTAAAAGTGCTTTGTAAGACTAGATTGAGCTGTTTCTGAGGGCGGTCACCAG TTGTGTTGGGGTCTGGTTTGAGTGCCTTCTGCCAAAATGTTGTGATGGAGGTGTTTCTGCGACCAGACACAGGATACCGCTGTGTCTGCA CCCGGTTGCCTGCATGGCCAGAGGAAAAGTCAGTTGGATTAAACATCATGGTATACTTGGCTGTTGTTTTTTTTTAATTTTTTAATTTTT TGGGATAGGGCCTCGCTCTGTCACCCAGGCTGGAGAACAGTGGGATGATCATGGCTCACTGCAGCCTTGAATTCCTAGGTTCAAGCAATC CTCCCACGTCAGCCTCCTGAGTAGCTAGGACTACAGGTGCATGCCACCTTTCCTGGCTAATTTATTTTTTGGGTAGAGATGGGGTCTTGA ACTCTTAGGCTCAAGTGATCCTCCTTCCTTGGCCTCCCAAAATGCTGGAATTAGAGATGTAAGCCACCATGCCCAGCCATAGTACTTGGA TGTTTTAGAAGGTTTTCCAAGTATTACATAATTCCTAGATGTTCACCCTTATTACACTCCAACTATTAAAAAGGTCAAAATTCAGCCTAT TTTTTTTCATTATTTTAGATTCCTGTGGTTGGGATATTTTAACATTGATGAGAAAAATAATTGAGGTTGATATTTTTACAAAATCATGCG GTAATAAGTCTTGATTTCATGATTCAAAAGAATCAATAAAGCCTAAAAATAATAGATTACTTTAAGCTGCTATGTAAGATATATATGGAA TAAATTAAAAACCTTTGTGAATTCAGGTTTATTATTTTTAACCTAAAACATTCTCTTTGGTTCATTCATCCCCTCATGTCATGGGGGCTC ATTGGTTTTCCTTCTTTGTCATATTTAAGTATGATTTTTCAACAAAACTTCTAGAAGTCAGCTTATTATGTCACCATTCATGCAAAGTGC TCATGCCTCTGATTGGTCCATTCACTGACGTGACAATTTCAGGTCCTATGTTTAAAAAGAAGGGGCTGGCCGGGCACGATGGCTCACGCC TATAATCCCAGCACTTTGGGAGGCCGAGAGGGGCGGTTCACGAGGTCAGGAGATTGAGACCATCCTGGTTAGCAGAGTGAAACCCCGTCT CTACTAAAAATACAAATAAAAATTAGCCGGGCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCAT GAACCCGGGAGGCAGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCTGTCTCAAAAAAAAA AAGGAGGGGGGCTAAATATCCAGTGAGATGCACTGAGGAAAGGAAGCATTTTGCTGAAGACAGCAGCAGCAACAAACAATGGTCTGTTTG TTGCAAACAAGATGTAGCTTGATTTCTGGTCTGACATATGCCATATACAGATATTAGAAACGACTGTTTGAAGGCCACACTGGTCATCTA CAAAGTAATGTTTACCAATTGACGACAGGGATTTAACTAGATTAAAAAGATCAAAGTGTGGTTTTTCTCTGCTTTTTAAAATTTCACTCG GAATTTGTAGCTGGGCCAATTCAACACATTTTACTTTTCAGTGGAATTGATTTTTCTAATGTTTCAGAATTTTAACATATCAAGAAGAAA ACAACGTTCTCAAAGTCTGGCCTCTTTAGCATGATGTAAACCTATAGAAATGCTTTGAAATGTGCTGGTGTAAGATAAGAGTTATCTTGT ATGATTTAATCATATGCAGTGTTGTCTCAGTTACGTTCAGGGAAATGTTTCTGTGTCATTCAGAGATGCTTGATGAATTAACACCTCCCA CCCTGAGTGAGGGGTTGACTTGTTGGGAGATGATTTGGGCTTCACTGGGATCTGTGACAGGTGGGGGCTGGGCTGGGTGTCACAAAGAGA ATAGTGGTAGAAATCGGGCGAAGGAAGAAAGAAGTTACTGGTAAAAATCATTACACCATAAAGCACCAAGGAAATAACTGAGTTAAAATA GGTGAAGTTTCTTTTTTCCCCCCTGTAACAGGAGAGTTTTCCTTATGATAATTATTCTGAGACTTGGTCACTTTGTTTTTGAATGTGGAG CTGCTGAACTCATTCAGAAGCCATTTGCTGCCTATCAGGACTTTCTGAAGAAGTTCTTTTGCCTCTGCCTACCCTCTGGCACCCTCCCAT GGAGGCACAGGGGACCCAGAGCTAAAGCATTACCAGGCCATCTCCAAAACACCCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG TGTGTGTGTGCACTTTGCAGCCCCCGAGGTGGAGAGGCAGTGTCTGGATCACTGTGAATGCATTGCCCCATTGGTCAGTTGGGGACACTG TTACAAATCCACTGAAGTCCTGGTAAAACTGTCAAGAGTAACAGGCCTCTTCTGTTCTACCCTGCTCACTTCCACGGTGAGTTACCAGCC TGGGCAACACAGCAAGACCCCATCTCTACAAAAAAAATTTTTTTAAGTAATTAACCGTTTAAATTTTTTCCTAAAGATTTAACATGATTT TTCCCTCCTATGTAAAGTTTACTGGAGAGACTTGAATTACTTAAATTCATGTTAATATGATTTTTTTTTAATCCAGGTCACATTTTAACA AAGTTTATTATGAAACAAATGAAATTTGAACTCTAAAATGGTACTCCTTGGCTTCCTCAAGTCACAATGAACTTTATATTTTCTTTGTCC TTAAGGACTAAGATAGTTGTTTTATTTCAGCCGAATCACAGAGATAACCACTCCTGCAGGCCCCCACAGCTGGCCCAAAGGGGCTGTCTT TCTGACCTGGCTGTGTTAGCACTGATTGAGAAACGCAGGCTCCCAAATTTTAAATTGCCTTTATTAAAAACACAAACTACAGAAAATGGG TTAAGAGTATACGCATTTCATCAAACACATATAGGGGAAAAAATCCTTCAATTTAGAGTTAAATAACTCAGCTTTGTATAGTAGAGTTAG CGCTCCAGTATCTAACAATCTCAGAATCATCTCTGAAAACTGGTAACTATGCTTCCATTTTTAATTTTGTCCTAAATATCAGATGTCTTT GATGTAAGGGTAGGGAATGGAGAAATATTTTCAATTGTGTATTTGTATTACAAAGAACTTGAAATTTACTTTCTTAGTTGATTATATTAA ATGATGTATATATTATATGTGGTTTATAAGCTCAACACTGGCCATTTTTTTAGTTTTATTGTTAAATGGTATTTTTCTATGTTTAATTAT AATAGATCTGGCTTTTTCTGGATAGCATAAAGATCACTGAACTATATATATATAAGAAACAAGAGTTCTATTTTAGCACAAAGGCATTTT ATATTATTTATTGAATCCATAAGTTTGTTTTCGTCAAAAACATTCCATATTATTTCTGCTCCTTTTTATTTGTATAGTTTGTTATTTAAA GAAATGGCAGTCCTTCCTGTTCTTAATACAATAAAATTGAAATAATGCACCTAGTAATGTGGCCGACATCTCTTCTCACCACCATGGACT GTTTTCAACAACAGTTGATCTTCTGGTCTGTGCTGAGAGGCGCATGCATGTCTTTCGTCACGTCGGGCAGCACACCTGCTGTGAAATACT GCTTTCATCTACCTCTTCAGAAGGCTTCTTGCTTGTTGACAAGTACCGCAAAGGCTTTATTCTGGACTGGCTATCTCATAAAAGGATTTC TGTAAGACTTTGCAGTGTCATTCCCTCAGAACCTAGGTTTGTTTCTAAAGCCACGGTATTGTCCAGGAGCCCCTGTGTGTGGGGCAGGTA GCTATCCCTCCCATGTCATTAGTAATCCTTTAGGATTTAAGGTACAACTGGACAGCATCATTCCTTCCCCTTATTGTGCCAAATCCCCAC CATCAGCCTTGCCATTGCCTTAAGATTTGATTATTGCACCCAATTACCTAACCACTAAACAGAAAGGCCACCTTCACTCTTTGAAAAAGG CAAGCTGTGCTTAGAAACACTGCTTTTAAGAGTAGCACATTTGAGTGTGACTTTTTCCCCCCTTCACTATTTCAAAATGGTTTTGAAATG GGGTCTTAAAGGTAAGCGCCCTCATACATGACTGAAACTTTGTGAGAGGTCTTATATTTGAATGGACCCTTAATGATTTATGTGAAATAG AATGAAGTCCTGTCTCTGTGAGAGAACGTGCCTCCTCACTCATTTGTCTCTGTCTGTTTTCATAGCCATCAATATAGTAACATATTTACT ATATTCTTGAATACCCTTGAAGAAAGAAATCCGTTTTCTATTGTGCATTGCTATACGAAGTGAAGCCAGTAAACTAGATACTGTAAATCT AGATATTGTACCTAGACAAAATATCATTGGTTCTATCTCTTTTTGTATCTGTTGTGCCAGGGAAGGTTTATAATCCCTTCTCAGTATACA CTCACTAGTGCACGTCTGAAATAGTATCCCACGGGAGATGCTGCTCCACGTCTGAGGTCACCTGCCCTGTGTGGGGCACACCACCGTCAG CACCACCGTTTTTACAGTTACTTTGGAGCTGCTAGACTGGTTTTCTGTGTTGGTAAATTGCCTATATAAATCTGAATAAAAAGGATCTGT |
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FusionGenePPI for EHD1_ADRBK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EHD1 | AP2A1, CLTC, IGF1R, SNAP29, EHD3, EHD1, EPN1, EPN3, ANKFY1, VPS26A, MICAL1, RBSN, DGKQ, EHD4, RAB11FIP2, RAB8A, API5, ARIH2, ATE1, CTPS2, AASDHPPT, DRG2, FKBP9, PDCD10, STAT6, GTF3C4, KTN1, LIMD1, NOL3, NUBP1, PDE12, PGGT1B, PRKDC, STK39, UBA6, WARS, XPNPEP1, PLA2G4A, MICALL1, EGFR, FAM153B, FAS, TMEM25, CCNL2, SPANXN3, C19orf54, HSPB1, APOA1BP, PPP2R1A, STX12, STX7, TECR, TOMM22, WDFY1, FADD, FAM98B, OPA1, PRKRA, STXBP1, NTRK1, RAB11A, TINF2, PAPD5, SNW1, CDC5L, CDH1, TMX1, EXOC8, DLD | ADRBK2 | CCR4, CXCR4, GIT1, MYC, ADRBK1, HSPB1, NTRK1, SMURF1, ADRB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EHD1_ADRBK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EHD1_ADRBK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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