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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11134

FusionGeneSummary for EGR1_PLAT

check button Fusion gene summary
Fusion gene informationFusion gene name: EGR1_PLAT
Fusion gene ID: 11134
HgeneTgene
Gene symbol

EGR1

PLAT

Gene ID

1958

5327

Gene nameearly growth response 1plasminogen activator, tissue type
SynonymsAT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225T-PA|TPA
Cytomap

5q31.2

8p11.21

Type of geneprotein-codingprotein-coding
Descriptionearly growth response protein 1EGR-1nerve growth factor-induced protein Atranscription factor ETR103transcription factor Zif268zinc finger protein 225zinc finger protein Krox-24tissue-type plasminogen activatoralteplaseplasminogen/activator kringlereteplaset-plasminogen activator
Modification date2018052320180523
UniProtAcc

P18146

P00750

Ensembl transtripts involved in fusion geneENST00000239938, ENST00000270189, 
ENST00000429089, ENST00000220809, 
ENST00000352041, ENST00000519510, 
ENST00000429710, ENST00000524009, 
Fusion gene scores* DoF score5 X 6 X 3=9027 X 5 X 11=1485
# samples 726
** MAII scorelog2(7/90*10)=-0.362570079384708
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/1485*10)=-2.51387940265967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EGR1 [Title/Abstract] AND PLAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEGR1

GO:0006366

transcription by RNA polymerase II

19057511

HgeneEGR1

GO:0033233

regulation of protein sumoylation

19057511

HgeneEGR1

GO:0045893

positive regulation of transcription, DNA-templated

12560508

HgeneEGR1

GO:0045944

positive regulation of transcription by RNA polymerase II

19057511

HgeneEGR1

GO:0098759

cellular response to interleukin-8

20363028

TgenePLAT

GO:0031639

plasminogen activation

12694198|17849409|24196407

TgenePLAT

GO:0045861

negative regulation of proteolysis

1695900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7314-01AEGR1chr5

137805004

+PLATchr8

42051245

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000239938ENST00000270189EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000429089EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000220809EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000352041EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000519510EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000429710EGR1chr5

137805004

+PLATchr8

42051245

-
5CDS-intronENST00000239938ENST00000524009EGR1chr5

137805004

+PLATchr8

42051245

-

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FusionProtFeatures for EGR1_PLAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EGR1

P18146

PLAT

P00750

Transcriptional regulator (PubMed:20121949). Recognizesand binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in thepromoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylationstatus (PubMed:25258363, PubMed:25999311). Regulates thetranscription of numerous target genes, and thereby plays animportant role in regulating the response to growth factors, DNAdamage, and ischemia. Plays a role in the regulation of cellsurvival, proliferation and cell death. Activates expression ofp53/TP53 and TGFB1, and thereby helps prevent tumor formation.Required for normal progress through mitosis and normalproliferation of hepatocytes after partial hepatectomy. Mediatesresponses to ischemia and hypoxia; regulates the expression ofproteins such as IL1B and CXCL2 that are involved in inflammatoryprocesses and development of tissue damage after ischemia.Regulates biosynthesis of luteinizing hormone (LHB) in thepituitary (By similarity). {ECO:0000250|UniProtKB:P08046,ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:25258363,ECO:0000269|PubMed:25999311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EGR1_PLAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EGR1_PLAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EGR1EP300, CREBBP, CEBPB, NAB2, PITX1, NFATC1, TP53, PSMA3, RELA, NAB1, ERBB3, SREBF2, PFDN5, TBX2, SNAI1, SP1, PTEN, IL1B, SRA1, MDM2, CDKN2A, WT1, FOSL2, JUNB, JUND, MAGEB2, PSMD2, MED6, POP1, DNAJC8, PHIP, ARID2, DNMT3L, CTNNB1, NFATC2, CIDEC, MIDN, NES, WDFY1PLATCLEC3B, CALR, PLAU, KRT8, ANXA2, SERPINI1, SERPINA5, F2, SERPINE1, FGA, LRP1, HMGB1, F10, FN1, LAMA1, TERF2, POT1, PDGFC, FGL1, DCN, TMEM25, PTPRK, IFNA14, LAMA3, SERPINB2, SERPING1, SERPINA10, PLA2G10, SERPINB6, SERPINE2, IGFBP1, DEFA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EGR1_PLAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLATP00750DB01050IbuprofenTissue-type plasminogen activatorsmall moleculeapproved
TgenePLATP00750DB06404Human C1-esterase inhibitorTissue-type plasminogen activatorbiotechapproved
TgenePLATP00750DB00513Aminocaproic AcidTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB01088IloprostTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09213DexibuprofenTissue-type plasminogen activatorsmall moleculeapproved|investigational
TgenePLATP00750DB09228Conestat alfaTissue-type plasminogen activatorbiotechapproved|investigational
TgenePLATP00750DB00013UrokinaseTissue-type plasminogen activatorbiotechapproved|investigational|withdrawn

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RelatedDiseases for EGR1_PLAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEGR1C0236736Cocaine-Related Disorders3CTD_human
HgeneEGR1C0008372Intrahepatic Cholestasis2CTD_human
HgeneEGR1C0004364Autoimmune Diseases1CTD_human
HgeneEGR1C0007786Brain Ischemia1CTD_human
HgeneEGR1C0008311Cholangitis1CTD_human
HgeneEGR1C0008370Cholestasis1CTD_human
HgeneEGR1C0020295Hydronephrosis1CTD_human
HgeneEGR1C0021368Inflammation1CTD_human
HgeneEGR1C0022116Ischemia1CTD_human
HgeneEGR1C0025500Mesothelioma1CTD_human
HgeneEGR1C0033578Prostatic Neoplasms1CTD_human
HgeneEGR1C0035126Reperfusion Injury1CTD_human
HgeneEGR1C0036341Schizophrenia1PSYGENET
HgeneEGR1C0242184Hypoxia1CTD_human
HgeneEGR1C0853193Bipolar I disorder1PSYGENET
HgeneEGR1C3495559Juvenile arthritis1CTD_human
TgenePLATC0038454Cerebrovascular accident59CTD_human
TgenePLATC0027051Myocardial Infarction35CTD_human
TgenePLATC0007786Brain Ischemia25CTD_human
TgenePLATC2937358Cerebral Hemorrhage21CTD_human
TgenePLATC0151699Intracranial Hemorrhages14CTD_human
TgenePLATC0034065Pulmonary Embolism9CTD_human
TgenePLATC0019080Hemorrhage8CTD_human
TgenePLATC0007785Cerebral Infarction6CTD_human
TgenePLATC0040053Thrombosis4CTD_human
TgenePLATC0740392Infarction, Middle Cerebral Artery4CTD_human
TgenePLATC0002994Angioedema3CTD_human
TgenePLATC0010072Coronary Thrombosis3CTD_human
TgenePLATC0042487Venous Thrombosis3CTD_human
TgenePLATC0007781Intracranial Embolism and Thrombosis2CTD_human
TgenePLATC0877172Hematoma, Epidural, Spinal2CTD_human
TgenePLATC0001125Acidosis, Lactic1CTD_human
TgenePLATC0001883Airway Obstruction1CTD_human
TgenePLATC0003537Aphasia1CTD_human
TgenePLATC0003838Arterial Occlusive Diseases1CTD_human
TgenePLATC0004153Atherosclerosis1CTD_human
TgenePLATC0004604Back Pain1CTD_human
TgenePLATC0004610Bacteremia1CTD_human
TgenePLATC0007177Cardiac Tamponade1CTD_human
TgenePLATC0013922Embolism1CTD_human
TgenePLATC0018801Heart failure1CTD_human
TgenePLATC0018946Hematoma, Subdural1CTD_human
TgenePLATC0020538Hypertensive disease1CTD_human
TgenePLATC0020649Hypotension1CTD_human
TgenePLATC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePLATC0024031Low Back Pain1CTD_human
TgenePLATC0025309Meningoencephalitis1CTD_human
TgenePLATC0027746Nerve Degeneration1CTD_human
TgenePLATC0030552Paresis1CTD_human
TgenePLATC0031039Pericardial effusion1CTD_human
TgenePLATC0033975Psychotic Disorders1PSYGENET
TgenePLATC0035126Reperfusion Injury1CTD_human
TgenePLATC0035229Respiratory Insufficiency1CTD_human
TgenePLATC0036341Schizophrenia1PSYGENET
TgenePLATC0036980Shock, Cardiogenic1CTD_human
TgenePLATC0037926Compression of spinal cord1CTD_human
TgenePLATC0040038Thromboembolism1CTD_human
TgenePLATC0085307Embolism and Thrombosis1CTD_human
TgenePLATC0149649Cholesterol Embolism1CTD_human
TgenePLATC0162820Dermatitis, Allergic Contact1CTD_human
TgenePLATC0235032Neurotoxicity Syndromes1CTD_human
TgenePLATC0236733Amphetamine-Related Disorders1CTD_human
TgenePLATC0242184Hypoxia1CTD_human
TgenePLATC0242698Ventricular Dysfunction, Left1CTD_human
TgenePLATC0349204Nonorganic psychosis1PSYGENET
TgenePLATC0740858Substance abuse problem1PSYGENET
TgenePLATC0751895Vasospasm, Intracranial1CTD_human
TgenePLATC0751955Brain Infarction1CTD_human
TgenePLATC0752143Intracranial Thrombosis1CTD_human
TgenePLATC1861172Venous Thromboembolism1CTD_human
TgenePLATC4277682Chemical and Drug Induced Liver Injury1CTD_human