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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1113

FusionGeneSummary for AGL_ARHGDIB

check button Fusion gene summary
Fusion gene informationFusion gene name: AGL_ARHGDIB
Fusion gene ID: 1113
HgeneTgene
Gene symbol

AGL

ARHGDIB

Gene ID

178

397

Gene nameamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseRho GDP dissociation inhibitor beta
SynonymsGDED4|GDIA2|GDID4|LYGDI|Ly-GDI|RAP1GN1|RhoGDI2
Cytomap

1p21.2

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionglycogen debranching enzymeamylo-1, 6-glucosidase, 4-alpha-glucanotransferaseamylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovidedglycogen debrancherglycogen debranching proteinrho GDP-dissociation inhibitor 2Rho GDI 2Rho GDP dissociation inhibitor (GDI) betarho-GDI beta
Modification date2018052320180523
UniProtAcc

P35573

P52566

Ensembl transtripts involved in fusion geneENST00000361915, ENST00000294724, 
ENST00000370165, ENST00000370163, 
ENST00000361302, ENST00000370161, 
ENST00000361522, ENST00000477753, 
ENST00000228945, ENST00000541644, 
ENST00000539131, ENST00000541546, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGL [Title/Abstract] AND ARHGDIB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGDIB

GO:0035023

regulation of Rho protein signal transduction

7512369

TgeneARHGDIB

GO:1901164

negative regulation of trophoblast cell migration

24554735


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J4-AATZ-01AAGLchr1

100382287

+ARHGDIBchr12

15103658

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361915ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361915ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000361915ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361915ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000294724ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000294724ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000294724ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000294724ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370165ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370165ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000370165ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370165ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370163ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370163ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000370163ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370163ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361302ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361302ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000361302ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361302ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370161ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370161ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000370161ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000370161ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361522ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361522ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-intronENST00000361522ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
5CDS-5UTRENST00000361522ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-
intron-5UTRENST00000477753ENST00000228945AGLchr1

100382287

+ARHGDIBchr12

15103658

-
intron-5UTRENST00000477753ENST00000541644AGLchr1

100382287

+ARHGDIBchr12

15103658

-
intron-intronENST00000477753ENST00000539131AGLchr1

100382287

+ARHGDIBchr12

15103658

-
intron-5UTRENST00000477753ENST00000541546AGLchr1

100382287

+ARHGDIBchr12

15103658

-

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FusionProtFeatures for AGL_ARHGDIB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGL

P35573

ARHGDIB

P52566

Regulates the GDP/GTP exchange reaction of the Rhoproteins by inhibiting the dissociation of GDP from them, and thesubsequent binding of GTP to them (PubMed:8356058,PubMed:7512369). Regulates reorganization of the actincytoskeleton mediated by Rho family members (PubMed:8262133).{ECO:0000269|PubMed:7512369, ECO:0000269|PubMed:8262133,ECO:0000269|PubMed:8356058}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AGL_ARHGDIB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGL_ARHGDIB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGLNHLRC1, PRKAA2, PRKAB2, RASSF5, CUL3, CUL4B, CUL5, CUL2, CUL1, COPS5, DCUN1D1, GLO1, DAK, BCAT1, PUS1, SERPINE2, SP100, VPS25, ASB3, ASB15, LGR4, MOV10, NXF1, ADSS, ASPSCR1, DERA, GARS, GCK, KHK, MAN2B1, MCFD2, PKM, PSMB6, RAN, SDHB, SPATA20, SULT1E1, TOM1L2, USP5, YTHDF2, CARKD, CAT, FKBP1A, FKBP1B, GCLC, GRHPR, NTRK1, AHSA1, FOXA2, RNF126, STBD1, BRCA1ARHGDIBVAV1, RAC2, RHOH, RAC3, RAC1, UFM1, APP, ZBTB1, RHOA, RHOC, SUMO4, WSB1, UBE3A, U2AF2, FBXL5, CDH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGL_ARHGDIB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGL_ARHGDIB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGLC0017922Glycogen Storage Disease Type III4CTD_human;ORPHANET;UNIPROT
HgeneAGLC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneARHGDIBC0019693HIV Infections1CTD_human
TgeneARHGDIBC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneARHGDIBC0948089Acute Coronary Syndrome1CTD_human