	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 11099

FusionGeneSummary for EGFLAM_EGFLAM

Fusion gene summary

Fusion gene information	Fusion gene name: EGFLAM_EGFLAM
	Fusion gene ID: 11099
		Hgene	Tgene
	Gene symbol	EGFLAM	EGFLAM
	Gene ID	133584	133584
	Gene name	EGF like, fibronectin type III and laminin G domains	EGF like, fibronectin type III and laminin G domains
	Synonyms	AGRINL\|AGRNL\|PIKA	AGRINL\|AGRNL\|PIKA
	Cytomap	5p13.2-p13.1	5p13.2-p13.1
	Type of gene	protein-coding	protein-coding
	Description	pikachurinEGF-like, fibronectin type-III and laminin G-like domain-containing proteinagrin-like protein	pikachurinEGF-like, fibronectin type-III and laminin G-like domain-containing proteinagrin-like protein
	Modification date	20180519	20180519
	UniProtAcc	Q63HQ2	Q63HQ2
	Ensembl transtripts involved in fusion gene	ENST00000354891, ENST00000322350, ENST00000336740, ENST00000397202, ENST00000397210, ENST00000506135, ENST00000514476,	ENST00000354891, ENST00000322350, ENST00000336740, ENST00000397202, ENST00000397210, ENST00000506135, ENST00000514476,
Fusion gene scores	* DoF score	2 X 3 X 1=6	2 X 3 X 1=6
	# samples	4	4
	** MAII score	log2(4/6*10)=2.73696559416621	log2(4/6*10)=2.73696559416621
Context	PubMed: EGFLAM [Title/Abstract] AND EGFLAM [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AL048127	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
ChiTaRS3.1			AL048116	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
ChiTaRS3.1			AL048126	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000354891	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000354891	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-3UTR	ENST00000322350	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
3UTR-intron	ENST00000322350	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000336740	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000336740	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000397202	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397202	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000397210	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000397210	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000506135	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000506135	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000354891	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-3UTR	ENST00000514476	ENST00000322350	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000336740	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000397202	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000397210	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000506135	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000514476	ENST00000514476	EGFLAM	chr5	38464790	-	EGFLAM	chr5	38464757	+
intron-intron	ENST00000354891	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000354891	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000354891	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000354891	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000354891	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000354891	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000354891	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-3UTR	ENST00000322350	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
3UTR-intron	ENST00000322350	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000336740	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000336740	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000397202	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397202	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000397210	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000397210	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000506135	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000506135	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000354891	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-3UTR	ENST00000514476	ENST00000322350	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000336740	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000397202	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000397210	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000506135	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+
intron-intron	ENST00000514476	ENST00000514476	EGFLAM	chr5	38464757	-	EGFLAM	chr5	38464790	+

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FusionProtFeatures for EGFLAM_EGFLAM

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EGFLAM Q63HQ2	EGFLAM Q63HQ2

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for EGFLAM_EGFLAM

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EGFLAM_EGFLAM

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for EGFLAM_EGFLAM

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EGFLAM_EGFLAM

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 11099

FusionGeneSummary for EGFLAM_EGFLAM

FusionProtFeatures for EGFLAM_EGFLAM

FusionGeneSequence for EGFLAM_EGFLAM

FusionGenePPI for EGFLAM_EGFLAM

RelatedDrugs for EGFLAM_EGFLAM

RelatedDiseases for EGFLAM_EGFLAM