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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 1109

FusionGeneSummary for AGGF1_RAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: AGGF1_RAF1
Fusion gene ID: 1109
HgeneTgene
Gene symbol

AGGF1

RAF1

Gene ID

55109

5894

Gene nameangiogenic factor with G-patch and FHA domains 1Raf-1 proto-oncogene, serine/threonine kinase
SynonymsGPATC7|GPATCH7|HSU84971|HUS84971|VG5QCMD1NN|CRAF|NS5|Raf-1|c-Raf
Cytomap

5q13.3

3p25.2

Type of geneprotein-codingprotein-coding
Descriptionangiogenic factor with G patch and FHA domains 1G patch domain-containing protein 7angiogenic factor VG5Qvasculogenesis gene on 5q proteinRAF proto-oncogene serine/threonine-protein kinaseC-Raf proto-oncogene, serine/threonine kinaseOncogene RAF1proto-oncogene c-RAFraf proto-oncogene serine/threonine protein kinasev-raf-1 murine leukemia viral oncogene homolog 1v-raf-1 murine leukemia
Modification date2018052320180523
UniProtAcc

Q8N302

P04049

Ensembl transtripts involved in fusion geneENST00000503538, ENST00000312916, 
ENST00000506806, 
ENST00000251849, 
ENST00000442415, ENST00000534997, 
ENST00000542177, 
Fusion gene scores* DoF score1 X 1 X 2=29 X 4 X 6=216
# samples 412
** MAII scorelog2(4/2*10)=4.32192809488736log2(12/216*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGGF1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGGF1

GO:0001938

positive regulation of endothelial cell proliferation

14961121

HgeneAGGF1

GO:0007155

cell adhesion

14961121

HgeneAGGF1

GO:0045766

positive regulation of angiogenesis

14961121

TgeneRAF1

GO:0000186

activation of MAPKK activity

10644344

TgeneRAF1

GO:0007190

activation of adenylate cyclase activity

15385642

TgeneRAF1

GO:0008285

negative regulation of cell proliferation

9765203

TgeneRAF1

GO:0031333

negative regulation of protein complex assembly

19667065

TgeneRAF1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneRAF1

GO:0043066

negative regulation of apoptotic process

19667065


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-CH-5737-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
TCGALDTHCATCGA-BJ-A2N7-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
TCGALDTHCATCGA-DJ-A2Q4-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
TCGALDTHCATCGA-EM-A1CS-01AAGGF1chr5

76335544

+RAF1chr3

12641914

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000503538ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000503538ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
In-frameENST00000312916ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000251849AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000442415AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000534997AGGF1chr5

76335544

+RAF1chr3

12641914

-
intron-3CDSENST00000506806ENST00000542177AGGF1chr5

76335544

+RAF1chr3

12641914

-

Top

FusionProtFeatures for AGGF1_RAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGGF1

Q8N302

RAF1

P04049

Promotes angiogenesis and the proliferation ofendothelial cells. Able to bind to endothelial cells and promotecell proliferation, suggesting that it may act in an autocrinefashion. {ECO:0000269|PubMed:14961121}. Serine/threonine-protein kinase that acts as aregulatory link between the membrane-associated Ras GTPases andthe MAPK/ERK cascade, and this critical regulatory link functionsas a switch determining cell fate decisions includingproliferation, differentiation, apoptosis, survival and oncogenictransformation. RAF1 activation initiates a mitogen-activatedprotein kinase (MAPK) cascade that comprises a sequentialphosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 andMAP2K2/MEK2) and the extracellular signal-regulated kinases(MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (onresidues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylylcyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation.Phosphorylates PPP1R12A resulting in inhibition of the phosphataseactivity. Phosphorylates TNNT2/cardiac muscle troponin T. Canpromote NF-kB activation and inhibit signal transducers involvedin motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2),proliferation and angiogenesis (RB1). Can protect cells fromapoptosis also by translocating to the mitochondria where it bindsBCL2 and displaces BAD/Bcl2-antagonist of cell death. RegulatesRho signaling and migration, and is required for normal woundhealing. Plays a role in the oncogenic transformation ofepithelial cells via repression of the TJ protein, occludin (OCLN)by inducing the up-regulation of a transcriptional repressorSNAI2/SLUG, which induces down-regulation of OCLN. Restrictscaspase activation in response to selected stimuli, notably Fasstimulation, pathogen-mediated macrophage apoptosis, and erythroiddifferentiation. {ECO:0000269|PubMed:11427728,ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642,ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194,ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233,ECO:0000269|PubMed:9360956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for AGGF1_RAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_661aa
MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSD
VEVQTENHAPWSISDTFTQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVKTRQVDHFASNSQEPASALAT
EDTSLEGSSLAESLRAAAEAAVSQTGFSTDENTGLTFDHSTGFTTDSENQLTTDPSTGITYTCDVESGRTQFHSRVDLQPTPTSSTKQSK
DKKLKKKRKDPDSSATNEEKDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSTTWEIEASE
VMLSTRIGSGSFGTVTKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQET
KFQMFQLIDIARQTAQGMDTLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ
SDVYSTGIVLTELMTGELPTSHINNRDQIIFMVGRGTASPDLSKLTKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_1983nt
ATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGCCCAGCTAAGGCGGAAGGTGGAG
AAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACACAGAACGGCTGTACCAGAACGCA
GAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAATGAAGATAATAAAAAGTCTGAT
GTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAATGACGTTAGTCTTCCAAATAAA
GTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTTACAAGTAGAAAATGATGCTTAC
CCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGAGCCAGCATCTGCATTAGCAACA
GAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATCACAGACTGGATTTAGTTATGAT
GAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTATGATCCTTCCACTGGAATTTAT
TACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGACTTCTAGCACAAAACAAAGTAAA
GATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAATTCGAAGTCACAGCGAATCAGCC
TCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGG
GCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAA
GTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAG
GTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTC
ATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACC
AAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGAC
ATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGT
TCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAG
TCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATC
TTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGT
GTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGG
AGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_3278nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT
GGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCACATCATGTGTATACAAGGA
AGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGTTATCTGATGGTCCCTCAAT

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_3081nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_2612nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_2546nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000251849_chr3_12641914_-_3278nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT
GGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCACATCATGTGTATACAAGGA
AGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGTTATCTGATGGTCCCTCAAT

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000442415_chr3_12641914_-_3081nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA
GGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTGTTGGCTACATGAGTATTTA
GAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGAGGAATGCATGTCACAGGCG
GGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCGAGACTCTGGCCGCCCGAAG
GAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAGTGCATTGGGATGGTTTTCC
AGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTCTTCCAGGAGCTGCCCCTAT

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000534997_chr3_12641914_-_2612nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG
CCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCCCCACATTCCCCATGCTCAA

>In-frame_AGGF1_ENST00000312916_chr5_76335544_+_RAF1_ENST00000542177_chr3_12641914_-_2546nt
GGTCCCGCCTGCCGCTGGCGCCGTTGTTTCCGGCTCAACTGGGGAGCTGCTGGAGCTCTTCTGGCCTCTGGTTTTCCGACTGCTTATCCG
ACGCTCCTCCCTCTGTCTCTGTAGCTGGAGAAGGTAGTTTCCAGGAAAGTTTTCCGGTTTGCAGGCCGCGCACATCGGGCAGGGGCCATC
CTCGGTCCCCTTGCTCGTTGCTCGCAGCCCCGTTCGGCTACAAGTGAGTTTCAGGGCGTCATGGCCAGGGGCCACCGCGGCCAGCCGGGT
GTGAGGCTGCCTTTCGCTGCCCGCGCGCTCCAGTGGTCTCTGGGTCCGCCGGCGTCCGTTTCGGCCTGAACGCAGCCCCTCCGCGGCGAC
GAGCAGTCTCGCGCCGGAGCTCATGGCCTCGGAGGCGCCGTCCCCGCCGCGGTCGCCGCCGCCGCCCACCTCCCCCGAGCCTGAGCTGGC
CCAGCTAAGGCGGAAGGTGGAGAAGTTGGAACGTGAACTGCGGAGCTGCAAGCGGCAGGTGCGGGAGATCGAGAAGCTGCTGCATCACAC
AGAACGGCTGTACCAGAACGCAGAAAGCAACAACCAGGAGCTCCGCACGCAGGTGGAAGAACTCAGTAAAATACTCCAACGTGGGAGAAA
TGAAGATAATAAAAAGTCTGATGTAGAAGTACAAACAGAGAACCATGCTCCTTGGTCAATCTCAGATTATTTTTATCAGACGTACTACAA
TGACGTTAGTCTTCCAAATAAAGTGACTGAACTGTCAGATCAACAAGATCAAGCTATCGAAACTTCTATTTTGAATTCTAAAGACCATTT
ACAAGTAGAAAATGATGCTTACCCTGGTACCGATAGAACAGAAAATGTTAAATATAGACAAGTGGACCATTTTGCCTCAAATTCACAGGA
GCCAGCATCTGCATTAGCAACAGAAGATACCTCCTTAGAAGGCTCATCATTAGCTGAAAGTTTGAGAGCTGCAGCAGAAGCGGCTGTATC
ACAGACTGGATTTAGTTATGATGAAAATACTGGACTGTATTTTGACCACAGCACTGGTTTCTATTATGATTCTGAAAATCAACTCTATTA
TGATCCTTCCACTGGAATTTATTACTATTGTGATGTGGAAAGTGGTCGTTATCAGTTTCATTCTCGAGTAGATTTGCAACCTTATCCGAC
TTCTAGCACAAAACAAAGTAAAGATAAAAAATTGAAGAAGAAAAGAAAAGATCCAGATTCTTCTGCAACAAATGAGGAAAAGGATGCAAT
TCGAAGTCACAGCGAATCAGCCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTGAGCCCAACAGGCTGGTCACAGCCGAAAACCCC
CGTGCCAGCACAAAGAGAGCGGGCACCAGTATCTGGGACCCAGGAGAAAAACAAAATTAGGCCTCGTGGACAGAGAGATTCAAGCTATTA
TTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATAAGGGTAAATGGCACGGAGA
TGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCGCAAAACACG
GCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCGAGGGCAGCAGCCTCTACAA
ACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGACTATTTGCATGC
AAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTGGAGATTTTGGTTTGGCAAC
AGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAGAGGTGATCCGAATGCAGGA
TAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGGAGCTTCCTTATTCTCACAT
CAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCAAT
GAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTTCCATTGAGCTGCTCCAACA
CTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACCAC
GTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCCAGCAGGCACCACTTTTCTG
CTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACAGGGCCTTAACTTCATGTTG


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FusionGenePPI for AGGF1_RAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGGF1CCDC85B, BLOC1S6, RAE1, SF3A2, ECT2, SNRPC, CHERP, AGGF1, TOE1, MAB21L3, MOV10, NXF1, ZC4H2, SCGN, YEATS4, MYO1C, XRCC3, NABP1, SIKE1, PARD6B, FOXK1, YAF2, IKBIP, UPF3A, RFWD2, ZNF414, ZNF785, ZNF408, IDH1RAF1YWHAQ, YWHAG, YWHAZ, SFN, HRAS, VDAC1, PEBP4, CNKSR1, RASD2, CNKSR2, ERAS, SPRY4, SPRY2, YWHAB, OIP5, PHKA2, CCT3, MYC, AR, MRAS, KRAS, LRPAP1, RRAS2, SHOC2, TSC22D3, STK26, MAPK1, MAPK3, PRKCE, BCL2, BCL2L1, PEBP1, MAP2K1, GRB10, NRAS, MAPK8IP3, AKT1, HSP90AA1, GNG4, GNB2, VAV1, RHEB, RAP1A, SRC, FYN, RB1, RBL2, PRKG1, JAK2, YWHAH, CFLAR, CDC25A, BRAF, MAP3K1, PDGFRB, MAP3K5, MAPK7, PHB, BAG1, PAK1, PRKCZ, RRAS, PRPF6, UBE2D2, YWHAE, NR3C1, LCK, LTK, JAK1, XIAP, BIRC2, BIRC3, STUB1, EEF1A1, HSPA8, HSPA5, CALM1, SGK1, NEDD4, SCNN1B, NEDD4L, STK3, BRAP, WDR83, KSR1, LATS1, MAP2K2, RFXANK, PPP1CC, VCP, HSPD1, BAD, BCL6, BIRC7, PIN1, MMS19, PPP2R1A, PPP2R2B, PPP2CA, HSPA4, RAF1, PPP2CB, MAPK8, RBBP8, YY1, PKM, CDK20, HIPK4, TBXA2R, SH3KBP1, ILK, GPRASP2, CDC37, IRS4, FAM96B, HUWE1, RANBP9, TMEM70, PACSIN3, NPLOC4, PRKAR1A, DCAF8, PURA, FYCO1, MYBPC1, COPS7A, MOV10, NXF1, EGFR, CALU, CCT8, DNAJA1, EMD, TIMM50, LOX, ARRB2, AGTR1, CASZ1, MRC2, PDLIM2, HERC2, XPO1, ACOX1, PCDH7, MAD2L1, SYNPO, TMEM63B, EEF1E1, COPS5, SS18L2, NUP133, RPGRIP1L, NCAPG2, NUP107, MSH2, LAS1L, AMER1, NUP160, EIF3D, SPATA7, NPHP4, DYNLL2, DYNLL1, IQCB1, RMDN3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGGF1_RAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRAF1P04049DB08896RegorafenibRAF proto-oncogene serine/threonine-protein kinasesmall moleculeapproved
TgeneRAF1P04049DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasesmall moleculeapproved|investigational
TgeneRAF1P04049DB08862CholecystokininRAF proto-oncogene serine/threonine-protein kinasesmall moleculeapproved|investigational
TgeneRAF1P04049DB08912DabrafenibRAF proto-oncogene serine/threonine-protein kinasesmall moleculeapproved|investigational

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RelatedDiseases for AGGF1_RAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGGF1C0022739Klippel-Trenaunay-Weber Syndrome1CTD_human;ORPHANET;UNIPROT
TgeneRAF1C1969057Noonan Syndrome 53CTD_human;UNIPROT
TgeneRAF1C0007194Hypertrophic Cardiomyopathy2CTD_human;HPO
TgeneRAF1C0028326Noonan Syndrome2CTD_human;ORPHANET
TgeneRAF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRAF1C0007193Cardiomyopathy, Dilated1CTD_human;HPO
TgeneRAF1C0017638Glioma1CTD_human
TgeneRAF1C0020429Hyperalgesia1CTD_human
TgeneRAF1C0022665Kidney Neoplasm1CTD_human
TgeneRAF1C0023903Liver neoplasms1CTD_human
TgeneRAF1C0024121Lung Neoplasms1CTD_human
TgeneRAF1C0175704LEOPARD Syndrome1CTD_human;ORPHANET
TgeneRAF1C0345967Malignant mesothelioma1CTD_human
TgeneRAF1C1458155Mammary Neoplasms1CTD_human
TgeneRAF1C4014656CARDIOMYOPATHY, DILATED, 1NN1UNIPROT