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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11064

FusionGeneSummary for EFNA3_CKS1B

check button Fusion gene summary
Fusion gene informationFusion gene name: EFNA3_CKS1B
Fusion gene ID: 11064
HgeneTgene
Gene symbol

EFNA3

CKS1B

Gene ID

1944

1163

Gene nameephrin A3CDC28 protein kinase regulatory subunit 1B
SynonymsEFL2|EPLG3|Ehk1-L|LERK3CKS1|PNAS-16|PNAS-18|ckshs1
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionephrin-A3EFL-2EHK1 ligandLERK-3eph-related receptor tyrosine kinase ligand 3ligand of eph-related kinase 3cyclin-dependent kinases regulatory subunit 1CDC2-associated protein CKS1CDC28 protein kinase 1BNB4 apoptosis/differentiation related proteincell division control protein CKS1
Modification date2018052320180523
UniProtAcc

P52797

P61024

Ensembl transtripts involved in fusion geneENST00000556931, ENST00000505139, 
ENST00000368408, ENST00000418360, 
ENST00000498667, 
ENST00000368439, 
ENST00000368436, ENST00000308987, 
ENST00000471245, ENST00000600888, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 2 X 3=18
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EFNA3 [Title/Abstract] AND CKS1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFNA3

GO:0016525

negative regulation of angiogenesis

18417479


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-A50Z-01AEFNA3chr1

155059945

+CKS1Bchr1

154951273

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000556931ENST00000368439EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000556931ENST00000368436EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000556931ENST00000308987EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000556931ENST00000471245EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000556931ENST00000600888EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000505139ENST00000368439EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000505139ENST00000368436EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000505139ENST00000308987EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000505139ENST00000471245EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000505139ENST00000600888EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
3UTR-3UTRENST00000368408ENST00000368439EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
3UTR-intronENST00000368408ENST00000368436EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
3UTR-3UTRENST00000368408ENST00000308987EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
3UTR-3UTRENST00000368408ENST00000471245EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
3UTR-intronENST00000368408ENST00000600888EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000418360ENST00000368439EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000418360ENST00000368436EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000418360ENST00000308987EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000418360ENST00000471245EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000418360ENST00000600888EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000498667ENST00000368439EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000498667ENST00000368436EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000498667ENST00000308987EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-3UTRENST00000498667ENST00000471245EFNA3chr1

155059945

+CKS1Bchr1

154951273

+
intron-intronENST00000498667ENST00000600888EFNA3chr1

155059945

+CKS1Bchr1

154951273

+

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FusionProtFeatures for EFNA3_CKS1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFNA3

P52797

CKS1B

P61024

Cell surface GPI-bound ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while thesignaling pathway downstream of the ephrin ligand is referred toas reverse signaling (By similarity). {ECO:0000250}. Binds to the catalytic subunit of the cyclin dependentkinases and is essential for their biological function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EFNA3_CKS1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EFNA3_CKS1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EFNA3PRSS23, EPHA7, EPHA3, MEOX2, KRTAP10-3, NOTCH2NLCKS1BSKP2, CDKN1B, CCNA2, CDK2, DUSP1, COPS6, PSMD9, CDC27, SKP1, CKS1BP7, KIAA0368, FZR1, CDC20, CUL1, COPS5, CCNB1, CDK1, CDK3, LDHB, CCNA1, CCNB2, SSBP1, HSP90AA1, CDC37, CDKN1A, XIAP, CDX4, CKS1B, KRTAP5-9, MEOX1, REL, TRIM27, TCF4, IKZF1, ARID5A, ROPN1, SEPT3, MIPOL1, SPERT, KRTAP10-9, SUMO1P1, TRIM49, GDPGP1, CDT1, GMNN, PKMYT1, CCNE2, CCNE1, ICK, IKZF5, CKS2, EEF1A2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EFNA3_CKS1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCKS1BP61024DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1small moleculeapproved|vet_approved

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RelatedDiseases for EFNA3_CKS1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource