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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11020

FusionGeneSummary for EFCAB10_RRP12

check button Fusion gene summary
Fusion gene informationFusion gene name: EFCAB10_RRP12
Fusion gene ID: 11020
HgeneTgene
Gene symbol

EFCAB10

RRP12

Gene ID

100130771

23223

Gene nameEF-hand calcium binding domain 10ribosomal RNA processing 12 homolog
Synonyms-KIAA0690
Cytomap

7q22.3

10q24.1

Type of geneprotein-codingprotein-coding
DescriptionEF-hand calcium-binding domain-containing protein 10EF-hand domain-containing proteinRRP12-like protein
Modification date2018042120180519
UniProtAcc

A6NFE3

Q5JTH9

Ensembl transtripts involved in fusion geneENST00000480514, ENST00000485614, 
ENST00000486180, ENST00000490493, 
ENST00000460135, 
ENST00000479481, 
ENST00000370992, ENST00000536831, 
ENST00000315563, ENST00000414986, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 5 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFCAB10 [Title/Abstract] AND RRP12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC007100EFCAB10chr7

105208836

+RRP12chr10

99154012

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000480514ENST00000479481EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000480514ENST00000370992EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000480514ENST00000536831EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000480514ENST00000315563EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000480514ENST00000414986EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000485614ENST00000479481EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000485614ENST00000370992EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000485614ENST00000536831EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000485614ENST00000315563EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000485614ENST00000414986EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000486180ENST00000479481EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000486180ENST00000370992EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000486180ENST00000536831EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000486180ENST00000315563EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000486180ENST00000414986EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000490493ENST00000479481EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000490493ENST00000370992EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000490493ENST00000536831EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000490493ENST00000315563EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000490493ENST00000414986EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000460135ENST00000479481EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000460135ENST00000370992EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000460135ENST00000536831EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000460135ENST00000315563EFCAB10chr7

105208836

+RRP12chr10

99154012

-
intron-intronENST00000460135ENST00000414986EFCAB10chr7

105208836

+RRP12chr10

99154012

-

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FusionProtFeatures for EFCAB10_RRP12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFCAB10

A6NFE3

RRP12

Q5JTH9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EFCAB10_RRP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EFCAB10_RRP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EFCAB10_RRP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EFCAB10_RRP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource