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Fusion gene ID: 11009 |
FusionGeneSummary for EEF2_SIAE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EEF2_SIAE | Fusion gene ID: 11009 | Hgene | Tgene | Gene symbol | EEF2 | SIAE | Gene ID | 1938 | 54414 |
| Gene name | eukaryotic translation elongation factor 2 | sialic acid acetylesterase | |
| Synonyms | EEF-2|EF-2|EF2|SCA26 | AIS6|CSE-C|CSEC|LSE|YSG2 | |
| Cytomap | 19p13.3 | 11q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | elongation factor 2polypeptidyl-tRNA translocase | sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P13639 | Q9HAT2 | |
| Ensembl transtripts involved in fusion gene | ENST00000309311, ENST00000600720, | ENST00000263593, ENST00000545756, ENST00000525730, | |
| Fusion gene scores | * DoF score | 30 X 23 X 17=11730 | 32 X 5 X 12=1920 |
| # samples | 50 | 36 | |
| ** MAII score | log2(50/11730*10)=-4.55213110825378 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(36/1920*10)=-2.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EEF2 [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SIAE | GO:0005975 | carbohydrate metabolic process | 23308225 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-CW-5581-01A | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000309311 | ENST00000263593 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| 5CDS-intron | ENST00000309311 | ENST00000545756 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| 5CDS-intron | ENST00000309311 | ENST00000525730 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| intron-3CDS | ENST00000600720 | ENST00000263593 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| intron-intron | ENST00000600720 | ENST00000545756 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
| intron-intron | ENST00000600720 | ENST00000525730 | EEF2 | chr19 | 3976055 | - | SIAE | chr11 | 124543777 | - |
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FusionProtFeatures for EEF2_SIAE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EEF2 | SIAE |
| Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome. | Catalyzes the removal of O-acetyl ester groups fromposition 9 of the parent sialic acid, N-acetylneuraminic acid. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EEF2 | chr19:3976055 | chr11:124543777 | ENST00000309311 | - | 15 | 15 | 17_362 | 1025 | 859 | Domain | tr-type G |
| Hgene | EEF2 | chr19:3976055 | chr11:124543777 | ENST00000309311 | - | 15 | 15 | 104_108 | 1025 | 859 | Nucleotide binding | GTP |
| Hgene | EEF2 | chr19:3976055 | chr11:124543777 | ENST00000309311 | - | 15 | 15 | 158_161 | 1025 | 859 | Nucleotide binding | GTP |
| Hgene | EEF2 | chr19:3976055 | chr11:124543777 | ENST00000309311 | - | 15 | 15 | 26_33 | 1025 | 859 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EEF2_SIAE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EEF2_ENST00000309311_chr19_3976055_-_SIAE_ENST00000263593_chr11_124543777_-_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EEF2_ENST00000309311_chr19_3976055_-_SIAE_ENST00000263593_chr11_124543777_-_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EEF2_ENST00000309311_chr19_3976055_-_SIAE_ENST00000263593_chr11_124543777_-_8747nt AGCGTTCTCTTCCGCCGTCGTCGCCGCCATCCTCGGCGCGACTCGCTTCTTTCGGTTCTACCTGGGAGAATCCACCGCCATCCGCCACCA TGGTGAACTTCACGGTAGACCAGATCCGCGCCATCATGGACAAGAAGGCCAACATCCGCAACATGTCTGTCATCGCCCACGTGGACCATG GCAAGTCCACGCTGACAGACTCCCTGGTGTGCAAGGCGGGCATCATCGCCTCGGCCCGGGCCGGGGAGACACGCTTCACTGATACCCGGA AGGACGAGCAGGAGCGTTGCATCACCATCAAGTCAACTGCCATCTCCCTCTTCTACGAGCTCTCGGAGAATGACTTGAACTTCATCAAGC AGAGCAAGGACGGTGCCGGCTTCCTCATCAACCTCATTGACTCCCCCGGGCATGTCGACTTCTCCTCGGAGGTGACTGCTGCCCTCCGAG TCACCGATGGCGCATTGGTGGTGGTGGACTGCGTGTCAGGCGTGTGCGTGCAGACGGAGACAGTGCTGCGGCAGGCCATTGCCGAGCGCA TCAAGCCTGTGCTGATGATGAACAAGATGGACCGCGCCCTGCTGGAGCTGCAGCTGGAGCCCGAGGAGCTCTACCAGACTTTCCAGCGCA TCGTGGAGAACGTGAACGTCATCATCTCCACCTACGGCGAGGGCGAGAGCGGCCCCATGGGCAACATCATGATCGATCCTGTCCTCGGTA CCGTGGGCTTTGGGTCTGGCCTCCACGGGTGGGCCTTCACCCTGAAGCAGTTTGCCGAGATGTATGTGGCCAAGTTCGCCGCCAAGGGGG AGGGCCAGTTGGGGCCTGCCGAGCGGGCCAAGAAAGTAGAGGACATGATGAAGAAGCTGTGGGGTGACAGGTACTTTGACCCAGCCAACG GCAAGTTCAGCAAGTCAGCCACCAGCCCCGAAGGGAAGAAGCTGCCACGCACCTTCTGCCAGCTGATCCTGGACCCCATCTTCAAGGTGT TTGATGCGATCATGAATTTCAAGAAAGAGGAGACAGCAAAACTGATAGAGAAACTGGACATCAAACTGGACAGCGAGGACAAGGACAAAG AAGGCAAACCCCTGCTGAAGGCTGTGATGCGCCGCTGGCTGCCTGCCGGAGACGCCTTGTTGCAGATGATCACCATCCACCTGCCCTCCC CTGTGACGGCCCAGAAGTACCGCTGCGAGCTCCTGTACGAGGGGCCCCCGGACGACGAGGCTGCCATGGGCATTAAAAGCTGTGACCCCA AAGGCCCTCTTATGATGTATATTTCCAAAATGGTGCCAACCTCCGACAAAGGTCGGTTCTACGCCTTTGGACGAGTCTTCTCGGGGCTGG TCTCCACTGGCCTGAAGGTCAGGATCATGGGGCCCAACTATACCCCTGGGAAGAAGGAGGACCTCTACCTGAAGCCAATCCAGAGAACAA TCTTGATGATGGGCCGCTACGTGGAGCCCATCGAGGATGTGCCTTGTGGGAACATTGTGGGCCTCGTGGGCGTGGACCAGTTCCTGGTGA AGACGGGCACCATCACCACCTTCGAGCACGCGCACAACATGCGGGTGATGAAGTTCAGCGTCAGCCCTGTTGTCAGAGTGGCCGTGGAGG CCAAGAACCCGGCTGACCTGCCCAAGCTGGTGGAGGGGCTGAAGCGGCTGGCCAAGTCCGACCCCATGGTGCAGTGCATCATCGAGGAGT CGGGAGAGCATATCATCGCGGGCGCCGGCGAGCTGCACCTGGAGATCTGCCTGAAGGACCTGGAGGAGGACCACGCCTGCATCCCCATCA AGAAATCTGACCCGGTCGTCTCGTACCGCGAGACGGTCAGTGAAGAGTCGAACGTGCTCTGCCTCTCCAAGTCCCCCAACAAGCACAACC GGCTGTACATGAAGGCGCGGCCCTTCCCCGACGGCCTGGCCGAGGACATCGATAAAGGCGAGGTGTCCGCCCGTCAGGAGCTCAAGCAGC GGGCGCGCTACCTGGCCGAGAAGTACGAGTGGGACGTGGCTGAGGCCCGCAAGATCTGGTGCTTTGGGCCCGACGGCACCGGCCCCAACA TCCTCACCGACATCACCAAGGGTGTGCAGTACCTCAACGAGATCAAGGACAGTGTGGTGGCCGGCTTCCAGTGGGCCACCAAGGAGGGCG CACTGTGTGAGGAGAACATGCGGGGTGTGCGCTTCGACGTCCACGACGTCACCCTGCACGCCGACGCCATCCACCGCGGAGGGGGCCAGA TCATCCCCACAGCACGGCGCTGCCTCTATGCCAGTGTGCTGACCGCCCAGCCACGCCTCATGGAGCCCATCTACCTTGTGGAGATCCAGT GTCCAGAGCAGGTGGTCGGTGGCATCTACGGGGTTTTGAACAGGAAGCGGGGCCACGTGTTCGAGGAGTCCCAGGTGGCCGGCACCCCCA TGTTTGTGGTCAAGGCCTATCTGCCCGTCAACGAGTCCTTTGGCTTCACCGCTGACCTGAGGTCCAACACGGGCGGCCAGGCGTTCCCCC AGTGTGTGTTTGACCACTGGCAGATCCTGCCCGGAGACCCCTTCGACAACAGCAGCCGCCCCAGCCAGGTGGTGGCGGAGACCCGCAAGC GCAAGGGCCTGAAAGAAGGCATCCCTGCCCTGGACAACTTCCTGGACAAATTGTAGGCGGCCCTTCCTGCAGCGCCTGCCGCCCCGGGGA CTCGCAGCACCCACAGCACCACGTCCTCGAATTCTCAGACGACACCTGGAGACTGTCCCGACACAGCGACGCTCCCCTGAGAGGTTTCTG GGGCCCGCTGCGTGCCATCACTCAACCATAACACTTGATGCCGTTTCTTTCAATATTTATTTCCAGAGTCCGGAGGCAGCAGACACGCCC TCTTAGTAGGGACTTAATGGGCCGGTCGGGGAGGGGGAGGCGGGATGGGACACCCAACACTTTTTCCATTTCTTCAGAGGGAAACTCAGA TGTCCAAACTAATTTTAACAAACGCATTAAGAGGTTTATTTGGGTACATGGCCCGCAGTGGCTTTTGCCCCAGAAAGGGGAAAGGAACAC GCGGGTAGATGATTTCTAGCAGGCAGGAAGTCCTGTGCGGTGTCACCATGAGCACCTCCAGCTGTACTAGTGCCATTGGAATAATAAATT TGATAAGGTGGTGAAAAAAAAAAAAAAAACTACGGCGGCCGAGAAGGGGCGAGTACAGCCCAGTCCTGAGGTCGCGGGAGGCTGCGAGGA CTGCAAAAGGGTGGAGTCGGCCTCGCCCCCGCCCAGGCCCCGCCCCTGCCGGGAACCCACTTTCCCAGTCCTAGGCGGCGGTCAGATCCT TGCAAGCATGGTCGCGCCGGGGCTTGTACTCGGGCTGGTGCTGCCATTAATCCTGTGGGCCGACAGAAGTGCAGGTATTGGTTTTCGCTT TGCTTCATACATCAATAATGATATGGTGCTGCAGAAGGAGCCTGCTGGGGCAGTGATATGGGGCTTCGGTACACCTGGAGCCACAGTGAC CGTGACCCTGCGCCAAGGTCAGGAAACCATCATGAAGAAAGTGACCAGTGTGAAAGCTCACTCTGATACGTGGATGGTGGTACTGGATCC TATGAAGCCTGGAGGACCTTTCGAAGTGATGGCACAACAGACTTTGGAGAAAATAAACTTCACCCTGAGAGTTCATGACGTCCTGTTTGG AGATGTCTGGCTCTGTAGTGGGCAGAGTAACATGCAGATGACTGTGTTACAGATATTTAATGCTACAAGGGAGTTGTCTAACACTGCGGC ATATCAGTCTGTCCGCATCCTCTCTGTCTCTCCCATTCAAGCAGAGCAGGAGCTGGAGGACCTTGTTGCGGTTGACTTGCAGTGGTCTAA GCCCACCTCAGAAAACTTAGGCCATGGATATTTCAAGTACATGTCAGCAGTGTGCTGGCTCTTTGGACGTCACCTTTATGACACTCTGCA GTATCCCATCGGGCTGATCGCCTCCAGCTGGGGCGGGACACCCATTGAAGCCTGGTCATCTGGACGGTCACTGAAAGCCTGTGGGGTCCC TAAACAAGGGTCCATTCCATACGATTCTGTAACTGGTCCCAGTAAGCACTCTGTTCTCTGGAATGCCATGATCCATCCACTGTGCAATAT GACTCTGAAAGGGGTAGTATGGTACCAGGGGGAGTCCAATATAAATTATAACACGGATCTGTACAATTGCACATTCCCTGCACTCATCGA AGACTGGCGTGAAACCTTCCACCGTGGTTCCCAGGGGCAGACGGAGCGTTTCTTCCCATTTGGACTTGTCCAGTTATCTTCAGATTTGTC TAAGAAGAGCTCAGACGATGGATTTCCCCAGATCCGTTGGCATCAAACAGCAGACTTCGGCTATGTCCCCAACCCAAAGATGCCCAATAC TTTCATGGCTGTAGCTATGGATCTCTGTGATAGAGACTCGCCTTTTGGCAGCATCCACCCTCGAGATAAACAGACTGTGGCTTATCGGCT GCATTTGGGGGCCCGTGCTCTGGCTTATGGTGAGAAGAATTTGACCTTTGAAGGACCACTGCCTGAGAAGATAGAACTCTTGGCTCACAA GGGGCTGCTCAATCTCACATATTACCAGCAAATCCAGGTGCAGAAAAAGGACAACAAGATATTTGAGATCTCCTGTTGCAGTGACCATCG ATGCAAGTGGCTTCCAGCTTCTATGAACACCGTCTCCACCCAGTCCCTGACCCTGGCGATCGATTCTTGTCATGGCACTGTGGTTGCTCT CCGCTATGCTTGGACCACGTGGCCTTGTGAATATAAGCAGTGTCCCCTATACCACCCCAGTAGTGCCCTGCCAGCCCCTCCCTTCATTGC TTTCATTACAGACCAGGGTCCTGGACATCAGAGCAATGTTGCTAAATGACTGTTTCAGTATGATCAGAACTTAGATATAAGGATGGGTCC TTCAGATTTTAGCATTTAGGAGTTTCAATAATAACCATTGCTTTTAAAGGAAATTAATAGAAAGCCTCATTGAATGGCTTTCAGCTAGCA CATGGCTGTTTCTATATTCTGATGAGCCCAGGCTTATAGGTAACTTGAAATGCTTGCTTTTTGTTCCCTAGTTGGTCTAAGGGTCTGTAT TGGACTAATTCTGAACTACAGACAAATTGGACCTCAATGTCATTTACTTCCCTCATATTAATGGGAGTGAAATGTCTAATACTTTTGCCC CTTTTTATCCAGAGTTGTGGGAATCTCAGGATTGGAAGAGATTTTAAAGGCCACATAGGCCAGCTAGTGTTCATGTGTTCTTTATAAAAT TTCTCCCATCCAAGTACTAACCAGGCCCGACCCTGCTTAGCTTCCGAGATCAGATGAGATCAGGCGCGTTCAGGGTGATATGGCCGTAGA CGTCTTTACAAAATTCCTGACAGGTGGTTACTGAATCTCTCTATGAACTTTCCATTCAAAACTTTCCAAGTTTTTCCTTATGTGGAACCG AAATCTTTCTTTCTCCCGTGAAACTTTACTACTATCAGATAATTGAAGACAGATCTCTTTGTATTCTCTTCAAGCCCAAACCAATTCTGT TCCTTCAATCTAAATAGTGGTAATATGAATGTTTAAGAAATGAAATAAGAAACATGTGCAGGCACTTTGGAAGGTGCTAAGTGACTGCCC TAAGGAATGAAAAGCAAGGGCCAGGTGGGAGTAGCCCAGCGAAGGCACTTGGGCTGCCAGGAACAGGAGGCGTGGGAAACTCTGGCTTAG GAAAACATGAACACAGGGGCAACAGAGGCAAACTGTTGTTCGAGTTAAATATAAATCTCAGGCTCTTTAAAGGTAAAAGGTTTAAGGATA ATCCATTTGGAAGAAGAAAAGAGTGAGGCTGAAAGTAAAGCCACATGACAAGCATATAAAAAAAAATGCAGATGATACAAATATGAAAGA GGCCTTCAGTGTTTGTTTATTAAGAATCTTAATGCAGTTTACTGATGGATTAAAAACAGCTAACATTGTCTGAAAATTATGTTACCTATA AGAAGTTGGAAATAAATAAAAGCATAATCACTAGTGATGTGTATGTATTTATATCCACTTGCAAACTGTCCTTGAAGCATGTGAAAAGGA GTAAGAATACTATCTATGGGTAGCTTTCCTCCCCTTAATGTGAAAAATGAGAACTAAAGCAAAAAGCATCACTCACTGTACATATACAAT GTATTTTACGTAGTGTAAAAAATATGGTTTAGATAGTGAATATATTAATGAAATCATATGTAAATTTATTTTTAGTGGCTGAATAATTTA AAACATTATGTGGAATTCACTATGTTTCCCCCAATTTAGGAACTTTTTACTGTGTGAAAATGAAATTTATAATACTCTGTAGGGTGAATG ATGGTTTTTGCTTTAGTTCTACCCCTCTGTAGAGTTCCAAGGGGTTCTGGTGTAGCTCCAAACAGCAGGAATAACTTTGTCAGTGCCAAG ATTTTATTTAGTTAAAAAACAAAAAATCTACACACTTTACAAGGAACGTTGGCTCCCCTGAGGACTTCCTAGCATTCAACTCGTTCAGTT AACCCCTATTGCCCATGCTTTGACCTCTCATGCATCTGGCCCCATAGAAACCATGAACCTTGTAACAGATTGATGCCTGAGAAAAAGTCA ATCTACCCGTCCACTCCTCCACTCCCAATACACATACCCCCATGGGCTGTTCTAATTCGGGGGCAGCCAGAGGTAGCCAAGAACTCTAAG TCCAGATTCCTTTCACCTCCAGGAACCTAGAGTACATAGTGTGAAAAATACGGTTCAGGCAATGATTATGTTAATGACGCCATGCACATT CATTTTTAGTGGCTGAGTAATTTAAAACATGATGTGGGAATTCACTGCATTTCCCCAAATGTAAGAACTTTTTAGTTTTAAAATGAAATT TATAGTCACTGTAGAAAATTTGGACACTAAAGTATAAGCAAGTAAAAATCACCCCCAAATTCATCATTCAGAGAAACACTATTTTGCTGA ACCATTCACTTGACTTGAGTTATATAATTTTATACAGTACATATTATTTTGTAATCTGTGTTTTTGACTTACTTACTTTACCAAAATAAT TTTCTTATGTAAATAATAGAATATAGATTTAGAGTGTTTCAGTTTGTGGAAGCCTCATTTTATTTAACCAATTTCCTATTAATGGACATA TAGATTTTTAACAATTTTCTACTATTAAAATAATACTGTAATGAATATCACATGCAAACATCATACCACACTCGTCCAGTTATTTCTTAG GGTTCTTAACATGGAAGAGGATAAATATATATTTAAAATTTAGATATCTACAGCTTAACCCTCCCAAAGGATTAAACAACTTACATTCTC ACCAAGGTAGTCCTTTTTTTGCCCTCACCCTCATTGACACTGGATGTTGTCAAATTTAAAAAAAATCCTTAACAATCTGATAGATGAAAA GATAGTTTAAGTATACTAAGGCAGTGTTTTTCAAGGTGTTTTTGTTTTTGTTTTTGAGTTGGAGTTTTGCTCTGTTGCCCAGGCTGGAGT GCAGTGGCGCGGTCTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACA GGCGCGTGCCACCACGCCTGGCTAATTTTTTGTATTTTTATTAGAGACCGACTTAGCCAGGATGGTCTCGATCTCCTGACCTCTTGATCC ACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCTTTTCAAGTTTCTTAAATCCATGATCCATAGTAA AAACATTTTACACATATCTTCATACAAGTATATGTATATGTGGTATACGTACACACTATAGTTGTATATGCATTATAGCTGAAAAACCAG TTCAACCTTTCTACATGTGGTATGTTCCAAAAATTTTAAATGTCTTTCTAAAATGAGGCTCTTTTAATACGGGTATTACTCAGGCTGTAA TAGTGGGAAAATATTTGTTATATGATAAAAGCAGCATATATCATTTCTGTGTAAATGCCAGTATGCTCAAGCCATTTATGCAGAGAAAAA AAGAAAAACACTGCATTAACATTTTAAGCAGTCCCCTTCCCGATTTGCTATTATACAAAGTTTGTTTCTTTTACATTGTAAAGTGTATAC AACTTATAAAAAGACTATACTCAAAATCATAAAATACCAGTTAACTTAGCTTCTCAGTTTACAGTGGCCAGTGTGGTGTGCTCTAAACAC TGCTGCCTGATCCCTCCCTCTGCTGGTCAGATTTATTACTATAAAGTACCAATCCCATTTGTGTTGTCCTCAATTGGCAATTATGAATGG CAGTGCATTAACCATTCAATTCTCACCACTCCATCCCCATTCTTCTACTTCTGGGTCCTTTTGTCCCTCCCTTTCCAGACAGCCCTTGGT AACCTGCTGCTGGGTAACTAAGGCATCCCACAGGTAGTGTTGAGGTGTTAGGTGATAGAGTAAACCTCTACCTTAATGCTATTAACAGGG TCCAAAAATCCAGTTGCATGGAACATGGAGTTATATTATTACATGGCTAATGAAAAGACAGGACTAAGTCTGTTATAGAGTATGGGACTA ACCCCCAATTATATGTGAATTTGTGTTATCATATGGTTTCAGTGTACTGAGCTAAAAAGCACATTATCTGAGGTGCAATACAAAGGTTAA 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FusionGenePPI for EEF2_SIAE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EEF2 | TP53, MLLT3, POU5F1, UCHL5, PPP2R1A, PPP2R1B, NOP56, DISC1, PSMA3, NDRG1, HDGF, ARRB2, ISG15, FBXO25, EEF2K, CUL3, CUL4B, CUL5, CDK2, CUL1, COPS5, COPS6, CAND1, GRK5, RAD23A, RPL5, RPS6, RPS3A, RPL7, RPS4X, RPL7A, EEF1A1, RPS16, RPS23, RPL31, RPS24, RPL12, RPL4, RPS15A, RPL10A, RPL14, RPL6, RPL18, RPS7, RPL21, RPL11, RPL23, RPS2, RPS5, RPS19, TARS, MRPS5, HSPD1, HSPA8, EIF4A1, PABPC1, FARSA, RPLP0P6, XRCC6, RPL10L, FLOT2, RRM1, HNRNPA0, EPHA2, ERLIN2, RBM4, HNRNPH1, RHOT2, HNRNPDL, HNRNPL, DDX5, ATP6V1H, NUP62, HNRNPA3, UPF1, SMURF1, CCT2, HSP90AA1, HSP90AB1, FN1, VCAM1, ATF2, MLH1, EEF2KMT, UBL4A, ITGA4, NPM1, SMG1, ADRB2, HNRNPD, MAPK14, HIPK4, CDK18, CDK20, TARDBP, CDKN2A, BZW1, CASP7, CKB, CAPN1, FTO, GSR, PGD, TYMP, EIF4H, GINS2, MAT2A, PAK2, PFAS, RPS6KA1, XPO1, YWHAQ, SHFM1, LGR4, HUWE1, FUS, MDM2, RNF2, SIRT6, ARAF, BLK, BUB1B, CASK, CDK13, DAPK1, IRAK1, LIMK2, WEE1, ESR1, HNRNPA1, UNK, EP300, CALR, ABCC3, ABCD3, AHNAK, ARPC2, ATIC, ATP1B3, AURKA, CASP3, CSE1L, DPH1, DPH2, EEF1A2, ENO1, GSPT1, HSD17B10, NDUFV1, NOTCH2, PGK1, TAGLN, TAGLN2, TOMM40, TXN, HCFC1, HSD17B4, IPO4, ISYNA1, OPA1, RDX, TUBB, NTRK1, PTEN, PPME1, GAN, CRY1, CRY2, MCM2, SENP3, U2AF2, NFATC2, CDC73, WWP2, ZNF746, CDH1, FBXO9, DEFA1, SLC25A48, CYLD, DLD, DLST, DNM1L, PARK7, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1, HDAC6 | SIAE | FBXO6, PTPRK, CPE, HLA-B, ENTPD6, NPTX1, CNTNAP3, MANEAL, OAF, TMEM30A, MR1, COCH, FAM162A, GPR98, GFPT2, MOXD1, LNPEP, PLXNB2, TCTN1, POC1A, NDST2, SGSH, TENM3, ERAP1, MANBA, ITGA8, TMEM2, LAMB2, FASTKD3, CHSY3, GDF11, DDX47, TMEM131, ARSK, ARSB, MBTPS1, COL18A1, MANEA, NAAA, RPP38, NRP2, PTGFRN, PLTP, KIAA1161, DCBLD2, SEPN1, GALNT7, TGFBR3, MAN2B2, TMEM132A, GALNS, NAGLU, CTSF, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EEF2_SIAE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EEF2_SIAE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EEF2 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Hgene | EEF2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Hgene | EEF2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | EEF2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | EEF2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | EEF2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | EEF2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Hgene | EEF2 | C1836395 | SPINOCEREBELLAR ATAXIA 26 | 1 | ORPHANET;UNIPROT |
| Tgene | SIAE | C3150797 | AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6 | 1 | UNIPROT |
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