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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11006

FusionGeneSummary for EEF2_PEX14

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF2_PEX14
Fusion gene ID: 11006
HgeneTgene
Gene symbol

EEF2

PEX14

Gene ID

1938

5195

Gene nameeukaryotic translation elongation factor 2peroxisomal biogenesis factor 14
SynonymsEEF-2|EF-2|EF2|SCA26NAPP2|PBD13A|Pex14p|dJ734G22.2
Cytomap

19p13.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 2polypeptidyl-tRNA translocaseperoxisomal membrane protein PEX14NF-E2 associated polypeptide 2PTS1 receptor docking proteinperoxin-14peroxisomal membrane anchor protein PEX14peroxisomal membrane anchor protein Pex14p
Modification date2018052320180523
UniProtAcc

P13639

O75381

Ensembl transtripts involved in fusion geneENST00000309311, ENST00000600720, 
ENST00000356607, ENST00000538836, 
ENST00000492696, 
Fusion gene scores* DoF score30 X 23 X 17=117306 X 5 X 4=120
# samples 507
** MAII scorelog2(50/11730*10)=-4.55213110825378
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF2 [Title/Abstract] AND PEX14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePEX14

GO:0016561

protein import into peroxisome matrix, translocation

21525035

TgenePEX14

GO:0032091

negative regulation of protein binding

21976670

TgenePEX14

GO:0034453

microtubule anchoring

21525035

TgenePEX14

GO:0036250

peroxisome transport along microtubule

21525035

TgenePEX14

GO:0043433

negative regulation of DNA binding transcription factor activity

11863372

TgenePEX14

GO:0044721

protein import into peroxisome matrix, substrate release

21976670

TgenePEX14

GO:0045892

negative regulation of transcription, DNA-templated

11863372

TgenePEX14

GO:0051260

protein homooligomerization

12488033

TgenePEX14

GO:0065003

protein-containing complex assembly

21525035

TgenePEX14

GO:1901094

negative regulation of protein homotetramerization

21976670


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW874543EEF2chr19

3976308

+PEX14chr1

10690464

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000309311ENST00000356607EEF2chr19

3976308

+PEX14chr1

10690464

-
intron-intronENST00000309311ENST00000538836EEF2chr19

3976308

+PEX14chr1

10690464

-
intron-intronENST00000309311ENST00000492696EEF2chr19

3976308

+PEX14chr1

10690464

-
intron-3UTRENST00000600720ENST00000356607EEF2chr19

3976308

+PEX14chr1

10690464

-
intron-intronENST00000600720ENST00000538836EEF2chr19

3976308

+PEX14chr1

10690464

-
intron-intronENST00000600720ENST00000492696EEF2chr19

3976308

+PEX14chr1

10690464

-

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FusionProtFeatures for EEF2_PEX14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF2

P13639

PEX14

O75381

Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome. Peroxisome membrane protein that is an essentialcomponent of the peroxisomal import machinery. Functions as adocking factor for the predominantly cytoplasmic PTS1 receptor(PEX5). Plays a key role for peroxisome movement through a directinteraction with tubulin. {ECO:0000269|PubMed:21525035,ECO:0000269|PubMed:9653144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF2_PEX14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF2_PEX14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF2_PEX14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EEF2_PEX14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEF2C0001418Adenocarcinoma1CTD_human
HgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
HgeneEEF2C0024121Lung Neoplasms1CTD_human
HgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
HgeneEEF2C0027627Neoplasm Metastasis1CTD_human
HgeneEEF2C0029408Degenerative polyarthritis1CTD_human
HgeneEEF2C1458155Mammary Neoplasms1CTD_human
HgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261ORPHANET;UNIPROT
TgenePEX14C1832200Peroxisome biogenesis disorders3CTD_human
TgenePEX14C0043459Zellweger Syndrome2CTD_human;ORPHANET
TgenePEX14C0029927Ovarian Cysts1CTD_human