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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10996

FusionGeneSummary for EEF2_EEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF2_EEF2
Fusion gene ID: 10996
HgeneTgene
Gene symbol

EEF2

EEF2

Gene ID

1938

1938

Gene nameeukaryotic translation elongation factor 2eukaryotic translation elongation factor 2
SynonymsEEF-2|EF-2|EF2|SCA26EEF-2|EF-2|EF2|SCA26
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 2polypeptidyl-tRNA translocaseelongation factor 2polypeptidyl-tRNA translocase
Modification date2018052320180523
UniProtAcc

P13639

P13639

Ensembl transtripts involved in fusion geneENST00000309311, ENST00000600720, 
ENST00000309311, ENST00000600720, 
Fusion gene scores* DoF score30 X 23 X 17=117307 X 13 X 3=273
# samples 5017
** MAII scorelog2(50/11730*10)=-4.55213110825378
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/273*10)=-0.683366204782151
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF2 [Title/Abstract] AND EEF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ349979EEF2chr19

3980548

+EEF2chr19

3985461

-
ChiTaRS3.1BE173877EEF2chr19

3977925

-EEF2chr19

3982305

-
ChiTaRS3.1CN271708EEF2chr19

3981383

-EEF2chr19

3982967

-
ChiTaRS3.1BF801948EEF2chr19

3978117

-EEF2chr19

3979344

+
ChiTaRS3.1AI075687EEF2chr19

3982344

+EEF2chr19

3977241

+
ChiTaRS3.1CD580061EEF2chr19

3981383

-EEF2chr19

3982967

-
ChiTaRS3.1BE763496EEF2chr19

3980915

+EEF2chr19

3976336

+
ChiTaRS3.1BF927334EEF2chr19

3976340

-EEF2chr19

3984194

-
ChiTaRS3.1CN263823EEF2chr19

3976672

+EEF2chr19

3976591

-
ChiTaRS3.1BQ347823EEF2chr19

3976563

-EEF2chr19

3976441

+
ChiTaRS3.1BF761203EEF2chr19

3976742

+EEF2chr19

3980695

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-3UTRENST00000309311ENST00000309311EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-3UTRENST00000600720ENST00000309311EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-5UTRENST00000309311ENST00000600720EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-5UTRENST00000600720ENST00000600720EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-3UTRENST00000309311ENST00000309311EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-3UTRENST00000600720ENST00000309311EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3976742

+EEF2chr19

3980695

-

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FusionProtFeatures for EEF2_EEF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF2

P13639

EEF2

P13639

Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome. Catalyzes the GTP-dependent ribosomal translocation stepduring translation elongation. During this step, the ribosomechanges from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-boundpeptidyl-tRNA and P-site-bound deacylated tRNA move to the P and Esites, respectively. Catalyzes the coordinated movement of the twotRNA molecules, the mRNA and conformational changes in theribosome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF2_EEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF2_EEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF2_EEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EEF2_EEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEF2C0001418Adenocarcinoma1CTD_human
HgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
HgeneEEF2C0024121Lung Neoplasms1CTD_human
HgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
HgeneEEF2C0027627Neoplasm Metastasis1CTD_human
HgeneEEF2C0029408Degenerative polyarthritis1CTD_human
HgeneEEF2C1458155Mammary Neoplasms1CTD_human
HgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261ORPHANET;UNIPROT
TgeneEEF2C0001418Adenocarcinoma1CTD_human
TgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
TgeneEEF2C0024121Lung Neoplasms1CTD_human
TgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
TgeneEEF2C0027627Neoplasm Metastasis1CTD_human
TgeneEEF2C0029408Degenerative polyarthritis1CTD_human
TgeneEEF2C1458155Mammary Neoplasms1CTD_human
TgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261ORPHANET;UNIPROT