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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10979

FusionGeneSummary for EEF1G_SLC22A6

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1G_SLC22A6
Fusion gene ID: 10979
HgeneTgene
Gene symbol

EEF1G

SLC22A6

Gene ID

1937

9356

Gene nameeukaryotic translation elongation factor 1 gammasolute carrier family 22 member 6
SynonymsEF1G|GIG35HOAT1|OAT1|PAHT|ROAT1
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chainsolute carrier family 22 member 6PAH transporterhPAHThROAT1organic anion transporter 1para-aminohippurate transporterrenal organic anion transporter 1solute carrier family 22 (organic anion transporter), member 6
Modification date2018052320180522
UniProtAcc

P26641

Q4U2R8

Ensembl transtripts involved in fusion geneENST00000329251, ENST00000378019, 
ENST00000532986, 
ENST00000360421, 
ENST00000377871, ENST00000458333, 
ENST00000421062, ENST00000537349, 
Fusion gene scores* DoF score4 X 3 X 3=364 X 1 X 4=16
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EEF1G [Title/Abstract] AND SLC22A6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC22A6

GO:0015711

organic anion transport

9950961|10049739

TgeneSLC22A6

GO:0015742

alpha-ketoglutarate transport

9950961


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-36-1578-01AEEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000329251ENST00000360421EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000329251ENST00000377871EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000329251ENST00000458333EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000329251ENST00000421062EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000329251ENST00000537349EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000378019ENST00000360421EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000378019ENST00000377871EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000378019ENST00000458333EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000378019ENST00000421062EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
5CDS-intronENST00000378019ENST00000537349EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
intron-intronENST00000532986ENST00000360421EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
intron-intronENST00000532986ENST00000377871EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
intron-intronENST00000532986ENST00000458333EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
intron-intronENST00000532986ENST00000421062EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-
intron-intronENST00000532986ENST00000537349EEF1Gchr11

62334278

-SLC22A6chr11

62703958

-

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FusionProtFeatures for EEF1G_SLC22A6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1G

P26641

SLC22A6

Q4U2R8

Probably plays a role in anchoring the complex to othercellular components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF1G_SLC22A6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF1G_SLC22A6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EEF1GEEF1DP3, EEF1D, EEF1B2, ILF2, ABCC9, EEF1G, ADAP2, CHFR, CXCL13, HDAC5, FAM195A, MVD, EFNA1, OGFOD2, FOXG1, C1orf174, NUP85, PLEKHA4, PHACTR3, ARF1, CBX8, CRELD1, DKC1, FEN1, ENOX1, NADK, NCK2, RPS28, SNAPIN, SNRPD2, TP53I3, TRIB3, GET4, MED31, ECH1, RECQL5, GSTO1, HMOX2, KARS, RPL4P5, PDCD5, PSMD11, RGL2, WDR33, ARIH2, CCT7, CDC42, CDK5RAP2, CSTF2, DLEU1, HNRNPH3, CCDC106, PTPN4, PTPRS, SAT1, TUBB3, ZNF24, VARS, LZTS1, CARS, LARS, HARS, EGFR, MYC, UCHL5, SNW1, AGO4, YWHAG, SIRT1, NUDT21, GSK3B, ZBED8, NUDT3, PTK2, TNNT1, AKT1, CDK2AP2, GADD45A, C11orf58, NDRG1, ISG15, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, NEDD8, GADD45G, GRB2, EEF1A1, RPL5, RPL8, HNRNPA3, SNRPA1, SRSF9, PLOD3, FLNC, STRIP1, SMURF1, YWHAE, FN1, VCAM1, MTNR1A, SKIL, MLH1, PAN2, IGSF8, NPM1, RAD52, ADRB2, FBXO6, TARDBP, TRAP1, CCT3, SHFM1, STAU1, TRIM63, TRIM55, FUS, RBM6, KLHL18, PLGRKT, ZDHHC17, CUL7, OBSL1, CCDC8, EED, SUMO2, SIRT6, ABL1, KTN1, INPPL1, EEF1A2, MKKS, RPS6KB2, HNRNPA1, ATL3, GTF2E1, GTF2E2, NACA, NPM3, PABPC1, RANGAP1, RPL38, IPO4, PRPF38B, NTRK1, ERBB2, EXOSC9, PKN2, SLC33A1, KIF20B, CHMP4B, MCM2, CDC73, WWP2, CDH1, CYLD, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, SDHA, SOAT1, SOD1, VDAC1, TRIM25, BRCA1SLC22A6APPBP2, APP, SLC25A23, SLC25A46, SLC20A2, SLC25A24, LPCAT3, GK, RAB32, SLC38A7, ERGIC3, ERGIC2, MCU, PDXDC1, CHPT1, SFXN5, SLC26A2, ATL2, MTX3, ITPRIP, NEDD4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF1G_SLC22A6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC22A6Q4U2R8DB00493CefotaximeSolute carrier family 22 member 6small moleculeapproved
TgeneSLC22A6Q4U2R8DB01212CeftriaxoneSolute carrier family 22 member 6small moleculeapproved
TgeneSLC22A6Q4U2R8DB01032ProbenecidSolute carrier family 22 member 6small moleculeapproved|investigational

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RelatedDiseases for EEF1G_SLC22A6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC22A6C0006663Calcinosis1CTD_human