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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10958

FusionGeneSummary for EEF1A1_SEC14L1

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1A1_SEC14L1
Fusion gene ID: 10958
HgeneTgene
Gene symbol

EEF1A1

SEC14L1

Gene ID

1915

6397

Gene nameeukaryotic translation elongation factor 1 alpha 1SEC14 like lipid binding 1
SynonymsCCS-3|CCS3|EE1A1|EEF-1|EEF1A|EF-Tu|EF1A|GRAF-1EF|HNGC:16303|LENG7|PTI1|eEF1A-1PRELID4A|SEC14L
Cytomap

6q13

17q25.2-q25.3

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-alpha 1CTCL tumor antigenEF-1-alpha-1EF1a-like proteincervical cancer suppressor 3elongation factor 1 alpha subunitelongation factor Tueukaryotic elongation factor 1 A-1eukaryotic translation elongation factor 1 alpha 1-like 14SEC14-like protein 1
Modification date2018052320180519
UniProtAcc

P68104

Q92503

Ensembl transtripts involved in fusion geneENST00000316292, ENST00000491404, 
ENST00000309268, ENST00000331523, 
ENST00000392476, ENST00000430767, 
ENST00000564509, ENST00000585618, 
ENST00000413679, ENST00000436233, 
ENST00000443798, ENST00000591437, 
ENST00000431431, 
Fusion gene scores* DoF score6 X 6 X 2=726 X 6 X 2=72
# samples 66
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF1A1 [Title/Abstract] AND SEC14L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEEF1A1

GO:0071364

cellular response to epidermal growth factor stimulus

9852145

TgeneSEC14L1

GO:0015871

choline transport

17092608


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF802691EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000316292ENST00000392476EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000430767EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000316292ENST00000564509EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000585618EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000413679EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000436233EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000316292ENST00000443798EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000591437EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000316292ENST00000431431EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000491404ENST00000392476EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000430767EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000491404ENST00000564509EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000585618EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000413679EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000436233EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000491404ENST00000443798EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000591437EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000491404ENST00000431431EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000309268ENST00000392476EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000430767EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000309268ENST00000564509EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000585618EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000413679EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000436233EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000309268ENST00000443798EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000591437EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000309268ENST00000431431EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000331523ENST00000392476EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000430767EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000331523ENST00000564509EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000585618EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000413679EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000436233EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-intronENST00000331523ENST00000443798EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000591437EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-
intron-3UTRENST00000331523ENST00000431431EEF1A1chr6

74228889

-SEC14L1chr17

75210153

-

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FusionProtFeatures for EEF1A1_SEC14L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1A1

P68104

SEC14L1

Q92503

This protein promotes the GTP-dependent binding ofaminoacyl-tRNA to the A-site of ribosomes during proteinbiosynthesis. With PARP1 and TXK, forms a complex that acts as a Thelper 1 (Th1) cell-specific transcription factor and binds thepromoter of IFN-gamma to directly regulate its transcription, andis thus involved importantly in Th1 cytokine production.{ECO:0000269|PubMed:17177976}. May play a role in innate immunity by inhibiting theantiviral RIG-I signaling pathway. In this pathway, functions as anegative regulator of DDX58/RIG-I, the cytoplasmic sensor of viralnucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1,an important step in signal propagation (PubMed:23843640). Mayalso regulate the SLC18A3 and SLC5A7 cholinergic transporters(PubMed:17092608). {ECO:0000269|PubMed:17092608,ECO:0000269|PubMed:23843640}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF1A1_SEC14L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF1A1_SEC14L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF1A1_SEC14L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEEF1A1P68104DB01593ZincElongation factor 1-alpha 1small moleculeapproved|investigational
HgeneEEF1A1P68104DB11638ArtenimolElongation factor 1-alpha 1small moleculeapproved|investigational

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RelatedDiseases for EEF1A1_SEC14L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEF1A1C0024667Animal Mammary Neoplasms1CTD_human
HgeneEEF1A1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneEEF1A1C0038356Stomach Neoplasms1CTD_human