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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10951

FusionGeneSummary for EED_AOAH

check button Fusion gene summary
Fusion gene informationFusion gene name: EED_AOAH
Fusion gene ID: 10951
HgeneTgene
Gene symbol

EED

AOAH

Gene ID

8726

313

Gene nameembryonic ectoderm developmentacyloxyacyl hydrolase
SynonymsCOGIS|HEED|WAIT1-
Cytomap

11q14.2

7p14.2

Type of geneprotein-codingprotein-coding
Descriptionpolycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development proteinacyloxyacyl hydrolaseacyloxyacyl hydrolase (neutrophil)
Modification date2018052320180523
UniProtAcc

O75530

P28039

Ensembl transtripts involved in fusion geneENST00000263360, ENST00000528180, 
ENST00000327320, ENST00000351625, 
ENST00000527888, 		ENST00000535891, 
ENST00000258749, ENST00000431169, 
ENST00000538464, ENST00000491444, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 4=144
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EED [Title/Abstract] AND AOAH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAOAH

GO:0006631

fatty acid metabolic process

1883828|29343645

TgeneAOAH

GO:0009104

lipopolysaccharide catabolic process

1883828|29343645


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA945120EEDchr11

85979547

+AOAHchr7

36573300

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263360ENST00000535891EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000263360ENST00000258749EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000263360ENST00000431169EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000263360ENST00000538464EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000263360ENST00000491444EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000528180ENST00000535891EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000528180ENST00000258749EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000528180ENST00000431169EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000528180ENST00000538464EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000528180ENST00000491444EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000327320ENST00000535891EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000327320ENST00000258749EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000327320ENST00000431169EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000327320ENST00000538464EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000327320ENST00000491444EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000351625ENST00000535891EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000351625ENST00000258749EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000351625ENST00000431169EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000351625ENST00000538464EEDchr11

85979547

+AOAHchr7

36573300

-
5CDS-intronENST00000351625ENST00000491444EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000527888ENST00000535891EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000527888ENST00000258749EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000527888ENST00000431169EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000527888ENST00000538464EEDchr11

85979547

+AOAHchr7

36573300

-
intron-intronENST00000527888ENST00000491444EEDchr11

85979547

+AOAHchr7

36573300

-

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FusionProtFeatures for EED_AOAH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EED

O75530

AOAH

P28039

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3,leading to transcriptional repression of the affected target gene.Also recognizes 'Lys-26' trimethylated histone H1 with the effectof inhibiting PRC2 complex methyltransferase activity onnucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognitionhas the opposite effect, enabling the propagation of thisrepressive mark. The PRC2/EED-EZH2 complex may also serve as arecruiting platform for DNA methyltransferases, thereby linkingtwo epigenetic repression systems. Genes repressed by thePRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.{ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106,ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737,ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870,ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918,ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}. Removes the secondary (acyloxyacyl-linked) fatty acylchains from the lipid A region of bacterial lipopolysaccharides(PubMed:1883828, PubMed:8089145, PubMed:29343645). By breakingdown LPS, terminates the host response to bacterial infection andprevents prolonged and damaging inflammatory responses (Bysimilarity). In peritoneal macrophages, seems to be important forrecovery from a state of immune tolerance following infection byGram-negative bacteria (By similarity).{ECO:0000250|UniProtKB:O35298, ECO:0000269|PubMed:1883828,ECO:0000269|PubMed:29343645, ECO:0000269|PubMed:8089145}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EED_AOAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EED_AOAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EED_AOAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EED_AOAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEDC0027809Neurilemmoma1CTD_human
HgeneEEDC0206727Nerve Sheath Tumors1CTD_human
TgeneAOAHC0236733Amphetamine-Related Disorders1CTD_human