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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10944

FusionGeneSummary for EEA1_MPG

check button Fusion gene summary
Fusion gene informationFusion gene name: EEA1_MPG
Fusion gene ID: 10944
HgeneTgene
Gene symbol

EEA1

MPG

Gene ID

8411

4350

Gene nameearly endosome antigen 1N-methylpurine DNA glycosylase
SynonymsMST105|MSTP105|ZFYVE2AAG|ADPG|APNG|CRA36.1|MDG|Mid1|PIG11|PIG16|anpg
Cytomap

12q22

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionearly endosome antigen 1early endosome antigen 1, 162kDearly endosome-associated proteinendosome-associated protein p162zinc finger FYVE domain-containing protein 2DNA-3-methyladenine glycosylase3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p3-alkyladenine DNA glycosylase3-methyladenine DNA glycosidaseCRA36.1 (3-methyl-adenine DNA glycosylase)N-methylpurine-DNA glycosylase, MP
Modification date2018052220180523
UniProtAcc

Q15075

P29372

Ensembl transtripts involved in fusion geneENST00000322349, ENST00000547833, 
ENST00000397817, ENST00000219431, 
ENST00000475280, 
Fusion gene scores* DoF score10 X 6 X 8=4802 X 2 X 2=8
# samples 125
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/8*10)=2.64385618977472
Context

PubMed: EEA1 [Title/Abstract] AND MPG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-04-1362-01AEEA1chr12

93285405

-MPGchr16

129424

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000322349ENST00000397817EEA1chr12

93285405

-MPGchr16

129424

+
5CDS-5UTRENST00000322349ENST00000219431EEA1chr12

93285405

-MPGchr16

129424

+
5CDS-3UTRENST00000322349ENST00000475280EEA1chr12

93285405

-MPGchr16

129424

+
5UTR-5UTRENST00000547833ENST00000397817EEA1chr12

93285405

-MPGchr16

129424

+
5UTR-5UTRENST00000547833ENST00000219431EEA1chr12

93285405

-MPGchr16

129424

+
5UTR-3UTRENST00000547833ENST00000475280EEA1chr12

93285405

-MPGchr16

129424

+

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FusionProtFeatures for EEA1_MPG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEA1

Q15075

MPG

P29372

Binds phospholipid vesicles containingphosphatidylinositol 3-phosphate and participates in endosomaltrafficking.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEA1_MPG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEA1_MPG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EEA1RAB22A, RAB5A, EEA1, STX12, NSF, RABEP1, RAB5C, IGF1R, PXK, PDCD6IP, RABGEF1, TNK2, VCP, ERBB2, CFTR, CCDC8, RNF2, BMI1, FCGR2A, PPP1R3C, MARS, PCNA, TP53, RRAD, NUPL1, MLLT6, SERPINB2, FUOM, BMP1, SNRNP27, TMA16, USP47, RAB31, PTPRQ, PIBF1, SNX27MPGLRRC59, FBLN1, GSTM3, GOT2, RANBP1, ESR1, HDGF, RAD23A, TERF2IP, PRNP, APP, MDC1, SRSF1, SERPINA12, UHRF1, RFC4, PKM, PRPF38B, PRDX1, NCBP1, FXR2, FLG, DHX33, CDSN, KHSRP, RACGAP1, GSN, CAPZA1, LHCGR, TFIP11, NOC2L, MORF4L1, CLASP2, SART1, PPP1R10, RPRD2, OBSCN, GNL3, TWISTNB, CSTF1, KDM2A, RRP1B, RRP7A, GNL2, LARP4, EXOSC9, CST6, KPRP, UHRF2, HECW2, RPA3, RPA2, RPA1, HSD17B14, IKBKAP, ELP3, ELP2, KBTBD4, EIF2A, KIFC1, CRK, HIST1H2BG, NPM1, RPL10, OTUB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEA1_MPG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMPGP29372DB00515CisplatinDNA-3-methyladenine glycosylasesmall moleculeapproved
TgeneMPGP29372DB01593ZincDNA-3-methyladenine glycosylasesmall moleculeapproved|investigational

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RelatedDiseases for EEA1_MPG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource