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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1092

FusionGeneSummary for AGBL4_AGBL4

check button Fusion gene summary
Fusion gene informationFusion gene name: AGBL4_AGBL4
Fusion gene ID: 1092
HgeneTgene
Gene symbol

AGBL4

AGBL4

Gene ID

84871

84871

Gene nameATP/GTP binding protein like 4ATP/GTP binding protein like 4
SynonymsCCP6CCP6
Cytomap

1p33

1p33

Type of geneprotein-codingprotein-coding
Descriptioncytosolic carboxypeptidase 6cytosolic carboxypeptidase 6
Modification date2018040320180403
UniProtAcc

Q5VU57

Q5VU57

Ensembl transtripts involved in fusion geneENST00000371839, ENST00000371838, 
ENST00000371836, ENST00000334103, 
ENST00000497451, 		ENST00000371839, 
ENST00000371838, ENST00000371836, 
ENST00000334103, ENST00000497451, 
Fusion gene scores* DoF score7 X 7 X 6=29412 X 10 X 7=840
# samples 1012
** MAII scorelog2(10/294*10)=-1.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AGBL4 [Title/Abstract] AND AGBL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ478184AGBL4chr1

49224857

+AGBL4chr1

49208322

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000371839ENST00000371839AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371839ENST00000371838AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371839ENST00000371836AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371839ENST00000334103AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371839ENST00000497451AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371838ENST00000371839AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371838ENST00000371838AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371838ENST00000371836AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371838ENST00000334103AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371838ENST00000497451AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371836ENST00000371839AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371836ENST00000371838AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371836ENST00000371836AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371836ENST00000334103AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000371836ENST00000497451AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000334103ENST00000371839AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000334103ENST00000371838AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000334103ENST00000371836AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000334103ENST00000334103AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000334103ENST00000497451AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000497451ENST00000371839AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000497451ENST00000371838AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000497451ENST00000371836AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000497451ENST00000334103AGBL4chr1

49224857

+AGBL4chr1

49208322

-
intron-intronENST00000497451ENST00000497451AGBL4chr1

49224857

+AGBL4chr1

49208322

-

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FusionProtFeatures for AGBL4_AGBL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGBL4

Q5VU57

AGBL4

Q5VU57

Metallocarboxypeptidase that mediates deglutamylation oftarget proteins. Catalyzes the deglutamylation of polyglutamateside chains generated by post-translational polyglutamylation inproteins such as tubulins. Also removes polyglutamates from thecarboxy-terminus of target proteins such as MYLK. Mediatesdeglutamylation of CGAS, regulating the antiviral activity ofCGAS. Acts as a long-chain deglutamylase and specifically shortenslong polyglutamate chains, while it is not able to remove thebranching point glutamate, a process catalyzed by AGBL5/CCP5.{ECO:0000250|UniProtKB:Q09LZ8}. Metallocarboxypeptidase that mediates deglutamylation oftarget proteins. Catalyzes the deglutamylation of polyglutamateside chains generated by post-translational polyglutamylation inproteins such as tubulins. Also removes polyglutamates from thecarboxy-terminus of target proteins such as MYLK. Mediatesdeglutamylation of CGAS, regulating the antiviral activity ofCGAS. Acts as a long-chain deglutamylase and specifically shortenslong polyglutamate chains, while it is not able to remove thebranching point glutamate, a process catalyzed by AGBL5/CCP5.{ECO:0000250|UniProtKB:Q09LZ8}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AGBL4_AGBL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGBL4_AGBL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGBL4_AGBL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGBL4_AGBL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGBL4C0236969Substance-Related Disorders1CTD_human
TgeneAGBL4C0236969Substance-Related Disorders1CTD_human