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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10910

FusionGeneSummary for ECT2_ECT2

check button Fusion gene summary
Fusion gene informationFusion gene name: ECT2_ECT2
Fusion gene ID: 10910
HgeneTgene
Gene symbol

ECT2

ECT2

Gene ID

1894

1894

Gene nameepithelial cell transforming 2epithelial cell transforming 2
SynonymsARHGEF31ARHGEF31
Cytomap

3q26.31

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionprotein ECT2epithelial cell-transforming sequence 2 oncogeneprotein ECT2epithelial cell-transforming sequence 2 oncogene
Modification date2018052220180522
UniProtAcc

Q9H8V3

Q9H8V3

Ensembl transtripts involved in fusion geneENST00000232458, ENST00000392692, 
ENST00000427830, ENST00000417960, 
ENST00000441497, ENST00000540509, 
ENST00000232458, ENST00000392692, 
ENST00000427830, ENST00000417960, 
ENST00000441497, ENST00000540509, 
Fusion gene scores* DoF score4 X 5 X 3=605 X 5 X 2=50
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ECT2 [Title/Abstract] AND ECT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneECT2

GO:0032147

activation of protein kinase activity

15254234

HgeneECT2

GO:0032467

positive regulation of cytokinesis

15545273

HgeneECT2

GO:0043065

positive regulation of apoptotic process

21373644

HgeneECT2

GO:0043547

positive regulation of GTPase activity

17115030|19617897|20047078

HgeneECT2

GO:0045859

regulation of protein kinase activity

15254234

HgeneECT2

GO:0051260

protein homooligomerization

15545273

HgeneECT2

GO:0070301

cellular response to hydrogen peroxide

21373644

HgeneECT2

GO:0071277

cellular response to calcium ion

15254234

HgeneECT2

GO:0071479

cellular response to ionizing radiation

21373644

HgeneECT2

GO:0090630

activation of GTPase activity

19617897

TgeneECT2

GO:0032147

activation of protein kinase activity

15254234

TgeneECT2

GO:0032467

positive regulation of cytokinesis

15545273

TgeneECT2

GO:0043065

positive regulation of apoptotic process

21373644

TgeneECT2

GO:0043547

positive regulation of GTPase activity

17115030|19617897|20047078

TgeneECT2

GO:0045859

regulation of protein kinase activity

15254234

TgeneECT2

GO:0051260

protein homooligomerization

15545273

TgeneECT2

GO:0070301

cellular response to hydrogen peroxide

21373644

TgeneECT2

GO:0071277

cellular response to calcium ion

15254234

TgeneECT2

GO:0071479

cellular response to ionizing radiation

21373644

TgeneECT2

GO:0090630

activation of GTPase activity

19617897


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE080860ECT2chr3

172504366

+ECT2chr3

172479400

+
ChiTaRS3.1BQ028167ECT2chr3

172472298

-ECT2chr3

172525675

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000232458ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000232458ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000232458ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000232458ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000232458ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000232458ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000392692ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000427830ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000417960ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000441497ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000232458ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000392692ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000427830ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000417960ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000441497ECT2chr3

172504366

+ECT2chr3

172479400

+
Frame-shiftENST00000540509ENST00000540509ECT2chr3

172504366

+ECT2chr3

172479400

+
intron-3CDSENST00000232458ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000232458ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000232458ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000232458ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000232458ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000232458ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000392692ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000427830ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000417960ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
5UTR-3CDSENST00000441497ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000232458ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000392692ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000427830ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000417960ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000441497ECT2chr3

172472298

-ECT2chr3

172525675

-
intron-3CDSENST00000540509ENST00000540509ECT2chr3

172472298

-ECT2chr3

172525675

-

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FusionProtFeatures for ECT2_ECT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECT2

Q9H8V3

ECT2

Q9H8V3

Guanine nucleotide exchange factor (GEF) that catalyzesthe exchange of GDP for GTP. Promotes guanine nucleotide exchangeon the Rho family members of small GTPases, like RHOA, RHOC, RAC1and CDC42. Required for signal transduction pathways involved inthe regulation of cytokinesis. Component of the centralspindlincomplex that serves as a microtubule-dependent and Rho-mediatedsignaling required for the myosin contractile ring formationduring the cell cycle cytokinesis. Regulates the translocation ofRHOA from the central spindle to the equatorial region. Plays arole in the control of mitotic spindle assembly; regulates theactivation of CDC42 in metaphase for the process of spindle fibersattachment to kinetochores before chromosome congression. Involvedin the regulation of epithelial cell polarity; participates in theformation of epithelial tight junctions in a polarity complexPARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role inthe regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity ofRAC1 through its association with the oncogenic PARD6A-PRKCIcomplex in cancer cells, thereby acting to coordinately drivetumor cell proliferation and invasion. Also stimulates genotoxicstress-induced RHOB activity in breast cancer cells leading totheir cell death. {ECO:0000269|PubMed:10579713,ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234,ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345,ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035,ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300,ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248,ECO:0000269|PubMed:21373644}. Guanine nucleotide exchange factor (GEF) that catalyzesthe exchange of GDP for GTP. Promotes guanine nucleotide exchangeon the Rho family members of small GTPases, like RHOA, RHOC, RAC1and CDC42. Required for signal transduction pathways involved inthe regulation of cytokinesis. Component of the centralspindlincomplex that serves as a microtubule-dependent and Rho-mediatedsignaling required for the myosin contractile ring formationduring the cell cycle cytokinesis. Regulates the translocation ofRHOA from the central spindle to the equatorial region. Plays arole in the control of mitotic spindle assembly; regulates theactivation of CDC42 in metaphase for the process of spindle fibersattachment to kinetochores before chromosome congression. Involvedin the regulation of epithelial cell polarity; participates in theformation of epithelial tight junctions in a polarity complexPARD3-PARD6-protein kinase PRKCQ-dependent manner. Plays a role inthe regulation of neurite outgrowth. Inhibits phenobarbital (PB)-induced NR1I3 nuclear translocation. Stimulates the activity ofRAC1 through its association with the oncogenic PARD6A-PRKCIcomplex in cancer cells, thereby acting to coordinately drivetumor cell proliferation and invasion. Also stimulates genotoxicstress-induced RHOB activity in breast cancer cells leading totheir cell death. {ECO:0000269|PubMed:10579713,ECO:0000269|PubMed:14645260, ECO:0000269|PubMed:15254234,ECO:0000269|PubMed:15545273, ECO:0000269|PubMed:15642749,ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16170345,ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16495035,ECO:0000269|PubMed:19129481, ECO:0000269|PubMed:19468300,ECO:0000269|PubMed:19617897, ECO:0000269|PubMed:21189248,ECO:0000269|PubMed:21373644}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ECT2_ECT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ECT2_ECT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ECT2PARD6A, KLHL20, PRKCZ, PARD3, RACGAP1, ABR, CD19, CSTB, EIF4A2, MBD1, MT2A, COX2, PCOLCE, PSMA6, RPS20, TCEB1, UBB, VDAC2, CHST10, EIF5B, NPC2, ILVBL, SNRNP200, NOMO1, ERAL1, POMP, C2orf42, CCDC91, OTUB1, THAP11, FANCM, SPATA22, GGN, OOSP2, CRIPAK, ALDH1B1, ATP2A2, CAPN1, CAPN2, CAPZA1, CDK5, CFL1, AP3S1, SLC25A10, CTBP1, CTBP2, CUX1, CYC1, DYNC1I2, ACSL1, FHL3, FLNA, XRCC6, GALK1, HNRNPC, HOXB9, EIF6, KPNB1, LDHA, LDHB, MCM6, MYO1D, NUMA1, NUP98, PDHB, PML, PPM1G, PPP1CA, PPP2CA, MAPK1, PSMD4, ABCD3, RFC2, RFC5, RPN1, SRSF1, SLC1A5, STRN, TCEB3, TCOF1, TP53, XRCC5, YWHAB, YWHAZ, USP11, USP9X, ARID1A, SLC25A11, SUCLG2, SUCLG1, TRIP13, GTF3C5, NPEPPS, RNF14, NUP93, UBE3C, GNB2L1, UNC13B, MYL12A, AHCYL1, CPSF4, CKAP4, IMMT, WDHD1, STRAP, XPOT, COPE, PHB2, KDM1A, TBC1D2B, LARP1, SIRT1, NUP188, PHGDH, COPG2, PELP1, STOML2, NUB1, PELO, CPSF2, DCAF16, CHCHD3, AGGF1, PPP6R3, IPO9, CAND1, RAD18, CCDC47, ESYT2, MICAL3, UBE2O, LPCAT1, PUS1, LAS1L, SLFN11, PPP1R18, PGAM5, CDH1, SRPK2, RPGRIP1L, GPSM2, SAMD1, RBM45, SKA3, WDR5, FOXM1, CDC5L, ARIH1, GKAP1, NPHP4ECT2PARD6A, KLHL20, PRKCZ, PARD3, RACGAP1, ABR, CD19, CSTB, EIF4A2, MBD1, MT2A, COX2, PCOLCE, PSMA6, RPS20, TCEB1, UBB, VDAC2, CHST10, EIF5B, NPC2, ILVBL, SNRNP200, NOMO1, ERAL1, POMP, C2orf42, CCDC91, OTUB1, THAP11, FANCM, SPATA22, GGN, OOSP2, CRIPAK, ALDH1B1, ATP2A2, CAPN1, CAPN2, CAPZA1, CDK5, CFL1, AP3S1, SLC25A10, CTBP1, CTBP2, CUX1, CYC1, DYNC1I2, ACSL1, FHL3, FLNA, XRCC6, GALK1, HNRNPC, HOXB9, EIF6, KPNB1, LDHA, LDHB, MCM6, MYO1D, NUMA1, NUP98, PDHB, PML, PPM1G, PPP1CA, PPP2CA, MAPK1, PSMD4, ABCD3, RFC2, RFC5, RPN1, SRSF1, SLC1A5, STRN, TCEB3, TCOF1, TP53, XRCC5, YWHAB, YWHAZ, USP11, USP9X, ARID1A, SLC25A11, SUCLG2, SUCLG1, TRIP13, GTF3C5, NPEPPS, RNF14, NUP93, UBE3C, GNB2L1, UNC13B, MYL12A, AHCYL1, CPSF4, CKAP4, IMMT, WDHD1, STRAP, XPOT, COPE, PHB2, KDM1A, TBC1D2B, LARP1, SIRT1, NUP188, PHGDH, COPG2, PELP1, STOML2, NUB1, PELO, CPSF2, DCAF16, CHCHD3, AGGF1, PPP6R3, IPO9, CAND1, RAD18, CCDC47, ESYT2, MICAL3, UBE2O, LPCAT1, PUS1, LAS1L, SLFN11, PPP1R18, PGAM5, CDH1, SRPK2, RPGRIP1L, GPSM2, SAMD1, RBM45, SKA3, WDR5, FOXM1, CDC5L, ARIH1, GKAP1, NPHP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ECT2_ECT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ECT2_ECT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneECT2C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneECT2C0023893Liver Cirrhosis, Experimental1CTD_human