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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10905

FusionGeneSummary for ECI1_CDKN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ECI1_CDKN3
Fusion gene ID: 10905
HgeneTgene
Gene symbol

ECI1

CDKN3

Gene ID

1632

1033

Gene nameenoyl-CoA delta isomerase 1cyclin dependent kinase inhibitor 3
SynonymsDCICDI1|CIP2|KAP|KAP1
Cytomap

16p13.3

14q22.2

Type of geneprotein-codingprotein-coding
Descriptionenoyl-CoA delta isomerase 1, mitochondrial3,2 trans-enoyl-Coenzyme A isomerase3,2-trans-enoyl-CoA isomerase, mitochondrialD3,D2-enoyl-CoA isomeraseacetylene-allene isomerasedelta(3),Delta(2)-enoyl-CoA isomerasedodecenoyl-CoA delta isomerase (3,2 tracyclin-dependent kinase inhibitor 3CDK2-associated dual specificity phosphataseCdk-associated protein phosphatasecyclin-dependent kinase inhibitorcyclin-dependent kinase interacting protein 2cyclin-dependent kinase interactor 1kinase-associated phos
Modification date2018052320180523
UniProtAcc

P42126

Q16667

Ensembl transtripts involved in fusion geneENST00000301729, ENST00000562238, 
ENST00000570258, 		ENST00000335183, 
ENST00000543789, ENST00000442975, 
ENST00000458126, ENST00000556102, 
ENST00000541304, ENST00000556305, 
ENST00000395577, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 4=64
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ECI1 [Title/Abstract] AND CDKN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDKN3

GO:0007050

cell cycle arrest

8242750


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-V1-A8WS-01AECI1chr16

2301317

-CDKN3chr14

54868242

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000301729ENST00000335183ECI1chr16

2301317

-CDKN3chr14

54868242

+
Frame-shiftENST00000301729ENST00000543789ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000301729ENST00000442975ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000301729ENST00000458126ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000301729ENST00000556102ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000301729ENST00000541304ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-3UTRENST00000301729ENST00000556305ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000301729ENST00000395577ECI1chr16

2301317

-CDKN3chr14

54868242

+
Frame-shiftENST00000562238ENST00000335183ECI1chr16

2301317

-CDKN3chr14

54868242

+
Frame-shiftENST00000562238ENST00000543789ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000562238ENST00000442975ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000562238ENST00000458126ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000562238ENST00000556102ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000562238ENST00000541304ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-3UTRENST00000562238ENST00000556305ECI1chr16

2301317

-CDKN3chr14

54868242

+
5CDS-intronENST00000562238ENST00000395577ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-3CDSENST00000570258ENST00000335183ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-3CDSENST00000570258ENST00000543789ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-intronENST00000570258ENST00000442975ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-intronENST00000570258ENST00000458126ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-intronENST00000570258ENST00000556102ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-intronENST00000570258ENST00000541304ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-3UTRENST00000570258ENST00000556305ECI1chr16

2301317

-CDKN3chr14

54868242

+
5UTR-intronENST00000570258ENST00000395577ECI1chr16

2301317

-CDKN3chr14

54868242

+

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FusionProtFeatures for ECI1_CDKN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECI1

P42126

CDKN3

Q16667

Able to isomerize both 3-cis and 3-trans double bondsinto the 2-trans form in a range of enoyl-CoA species.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ECI1_CDKN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ECI1_CDKN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ECI1ICT1, APP, ACOX1, MAPKAP1, POT1, FABP5, PRDX6, TAGLN2, HIBCH, TRIM25CDKN3CDK2, CDK1, MS4A3, NCOA3, BMI1, ROCK2, ROCK1, CDC42BPB, PPP1R12A, CDKN3, RAD23B, CLPB, GOPC, RAD23A, HAX1, BAG6, ARHGEF28, CECR5, DLAT, NAP1L4, DIS3L, SEC63


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ECI1_CDKN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ECI1_CDKN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDKN3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCDKN3C2239176Liver carcinoma1UNIPROT