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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10867

FusionGeneSummary for EBF4_EBF4

check button Fusion gene summary
Fusion gene informationFusion gene name: EBF4_EBF4
Fusion gene ID: 10867
HgeneTgene
Gene symbol

EBF4

EBF4

Gene ID

57593

57593

Gene nameearly B cell factor 4early B cell factor 4
SynonymsCOE4|O/E-4COE4|O/E-4
Cytomap

20p13

20p13

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor COE4OE-4olf-1/EBF-like 4transcription factor COE4OE-4olf-1/EBF-like 4
Modification date2018052320180523
UniProtAcc

Q9BQW3

Q9BQW3

Ensembl transtripts involved in fusion geneENST00000380648, ENST00000609451, 
ENST00000477287, 
ENST00000380648, 
ENST00000609451, ENST00000477287, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: EBF4 [Title/Abstract] AND EBF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF762042EBF4chr20

2735838

-EBF4chr20

2735958

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380648ENST00000380648EBF4chr20

2735838

-EBF4chr20

2735958

+
intron-intronENST00000380648ENST00000609451EBF4chr20

2735838

-EBF4chr20

2735958

+
intron-3UTRENST00000380648ENST00000477287EBF4chr20

2735838

-EBF4chr20

2735958

+
intron-intronENST00000609451ENST00000380648EBF4chr20

2735838

-EBF4chr20

2735958

+
intron-intronENST00000609451ENST00000609451EBF4chr20

2735838

-EBF4chr20

2735958

+
intron-3UTRENST00000609451ENST00000477287EBF4chr20

2735838

-EBF4chr20

2735958

+
3UTR-intronENST00000477287ENST00000380648EBF4chr20

2735838

-EBF4chr20

2735958

+
3UTR-intronENST00000477287ENST00000609451EBF4chr20

2735838

-EBF4chr20

2735958

+
3UTR-3UTRENST00000477287ENST00000477287EBF4chr20

2735838

-EBF4chr20

2735958

+

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FusionProtFeatures for EBF4_EBF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EBF4

Q9BQW3

EBF4

Q9BQW3

Transcriptional factor which recognizes variations ofthe palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}. Transcriptional factor which recognizes variations ofthe palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EBF4_EBF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EBF4_EBF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EBF4_EBF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EBF4_EBF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource