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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10864

FusionGeneSummary for EBF1_EBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: EBF1_EBF1
Fusion gene ID: 10864
HgeneTgene
Gene symbol

EBF1

EBF1

Gene ID

1879

1879

Gene nameearly B cell factor 1early B cell factor 1
SynonymsCOE1|EBF|O/E-1|OLF1COE1|EBF|O/E-1|OLF1
Cytomap

5q33.3

5q33.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor COE1Collier, Olf and EBF transcription factor 1olfactory neuronal transcription factor 1transcription factor COE1Collier, Olf and EBF transcription factor 1olfactory neuronal transcription factor 1
Modification date2018052320180523
UniProtAcc

Q9UH73

Q9UH73

Ensembl transtripts involved in fusion geneENST00000518836, ENST00000313708, 
ENST00000380654, ENST00000517373, 
ENST00000518836, ENST00000313708, 
ENST00000380654, ENST00000517373, 
Fusion gene scores* DoF score5 X 5 X 1=256 X 5 X 2=60
# samples 55
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EBF1 [Title/Abstract] AND EBF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA768060EBF1chr5

158484739

-EBF1chr5

158484478

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000518836ENST00000518836EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000518836ENST00000313708EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000518836ENST00000380654EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000518836ENST00000517373EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000313708ENST00000518836EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000313708ENST00000313708EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000313708ENST00000380654EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000313708ENST00000517373EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000380654ENST00000518836EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000380654ENST00000313708EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000380654ENST00000380654EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000380654ENST00000517373EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000517373ENST00000518836EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000517373ENST00000313708EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000517373ENST00000380654EBF1chr5

158484739

-EBF1chr5

158484478

+
intron-intronENST00000517373ENST00000517373EBF1chr5

158484739

-EBF1chr5

158484478

+

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FusionProtFeatures for EBF1_EBF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EBF1

Q9UH73

EBF1

Q9UH73

Transcriptional activator which recognizes variations ofthe palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}. Transcriptional activator which recognizes variations ofthe palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EBF1_EBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EBF1_EBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EBF1_EBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EBF1_EBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEBF1C0007621Neoplastic Cell Transformation1CTD_human
HgeneEBF1C0024301Lymphoma, Follicular1CTD_human
HgeneEBF1C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneEBF1C0007621Neoplastic Cell Transformation1CTD_human
TgeneEBF1C0024301Lymphoma, Follicular1CTD_human
TgeneEBF1C0035222Respiratory Distress Syndrome, Adult1CTD_human