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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10859

FusionGeneSummary for EBAG9_EBAG9

check button Fusion gene summary
Fusion gene informationFusion gene name: EBAG9_EBAG9
Fusion gene ID: 10859
HgeneTgene
Gene symbol

EBAG9

EBAG9

Gene ID

9166

9166

Gene nameestrogen receptor binding site associated, antigen, 9estrogen receptor binding site associated, antigen, 9
SynonymsEB9|PDAFEB9|PDAF
Cytomap

8q23.2

8q23.2

Type of geneprotein-codingprotein-coding
Descriptionreceptor-binding cancer antigen expressed on SiSo cellscancer-associated surface antigen RCAS1estrogen receptor-binding fragment-associated gene 9 proteinreceptor-binding cancer antigen expressed on SiSo cellscancer-associated surface antigen RCAS1estrogen receptor-binding fragment-associated gene 9 protein
Modification date2018052220180522
UniProtAcc

O00559

O00559

Ensembl transtripts involved in fusion geneENST00000395785, ENST00000529502, 
ENST00000337573, ENST00000531677, 
ENST00000395785, ENST00000529502, 
ENST00000337573, ENST00000531677, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: EBAG9 [Title/Abstract] AND EBAG9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI963170EBAG9chr8

110573112

-EBAG9chr8

110563046

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000395785ENST00000395785EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-3UTRENST00000395785ENST00000529502EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-5UTRENST00000395785ENST00000337573EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-intronENST00000395785ENST00000531677EBAG9chr8

110573112

-EBAG9chr8

110563046

+
intron-5UTRENST00000529502ENST00000395785EBAG9chr8

110573112

-EBAG9chr8

110563046

+
intron-3UTRENST00000529502ENST00000529502EBAG9chr8

110573112

-EBAG9chr8

110563046

+
intron-5UTRENST00000529502ENST00000337573EBAG9chr8

110573112

-EBAG9chr8

110563046

+
intron-intronENST00000529502ENST00000531677EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-5UTRENST00000337573ENST00000395785EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-3UTRENST00000337573ENST00000529502EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-5UTRENST00000337573ENST00000337573EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-intronENST00000337573ENST00000531677EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-5UTRENST00000531677ENST00000395785EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-3UTRENST00000531677ENST00000529502EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-5UTRENST00000531677ENST00000337573EBAG9chr8

110573112

-EBAG9chr8

110563046

+
5CDS-intronENST00000531677ENST00000531677EBAG9chr8

110573112

-EBAG9chr8

110563046

+

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FusionProtFeatures for EBAG9_EBAG9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EBAG9

O00559

EBAG9

O00559

May participate in suppression of cell proliferation andinduces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.{ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241,ECO:0000269|PubMed:12672804}. May participate in suppression of cell proliferation andinduces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.{ECO:0000269|PubMed:12054692, ECO:0000269|PubMed:12138241,ECO:0000269|PubMed:12672804}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EBAG9_EBAG9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EBAG9_EBAG9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EBAG9_EBAG9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EBAG9_EBAG9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource