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Fusion gene ID: 10850 |
FusionGeneSummary for E2F8_ZNF638 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: E2F8_ZNF638 | Fusion gene ID: 10850 | Hgene | Tgene | Gene symbol | E2F8 | ZNF638 | Gene ID | 79733 | 27332 |
| Gene name | E2F transcription factor 8 | zinc finger protein 638 | |
| Synonyms | E2F-8 | NP220|ZFML|Zfp638 | |
| Cytomap | 11p15.1 | 2p13.3-p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor E2F8E2F family member 8 | zinc finger protein 638CTCL tumor antigen se33-1CTCL-associated antigen se33-1NP220 nuclear proteincutaneous T-cell lymphoma-associated antigen se33-1nuclear protein 220zinc finger matrin-like protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | A0AVK6 | Q14966 | |
| Ensembl transtripts involved in fusion gene | ENST00000527884, ENST00000250024, ENST00000529188, | ENST00000410075, ENST00000377802, ENST00000355812, ENST00000409544, ENST00000264447, ENST00000409407, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 3=90 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: E2F8 [Title/Abstract] AND ZNF638 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | E2F8 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16179649 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA892965 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000527884 | ENST00000410075 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000527884 | ENST00000377802 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000527884 | ENST00000355812 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000527884 | ENST00000409544 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000527884 | ENST00000264447 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000527884 | ENST00000409407 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000410075 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000377802 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000355812 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000409544 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000264447 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| 5CDS-intron | ENST00000250024 | ENST00000409407 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000410075 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000377802 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000355812 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000409544 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000264447 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
| intron-intron | ENST00000529188 | ENST00000409407 | E2F8 | chr11 | 19258861 | - | ZNF638 | chr2 | 71623271 | + |
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FusionProtFeatures for E2F8_ZNF638 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| E2F8 | ZNF638 |
| Atypical E2F transcription factor that participates invarious processes such as angiogenesis and polyploidization ofspecialized cells. Mainly acts as a transcription repressor thatbinds DNA independently of DP proteins and specifically recognizesthe E2 recognition site 5'-TTTC[CG]CGC-3'. Directly repressestranscription of classical E2F transcription factors such as E2F1:component of a feedback loop in S phase by repressing theexpression of E2F1, thereby preventing p53/TP53-dependentapoptosis. Plays a key role in polyploidization of cells inplacenta and liver by regulating the endocycle, probably byrepressing genes promoting cytokinesis and antagonizing action ofclassical E2F proteins (E2F1, E2F2 and/or E2F3). Required forplacental development by promoting polyploidization of trophoblastgiant cells. Acts as a promoter of sprouting angiogenesis,possibly by acting as a transcription activator: associates withHIF1A, recognizes and binds the VEGFA promoter, which is differentfrom canonical E2 recognition site, and activates expression ofthe VEGFA gene. {ECO:0000269|PubMed:15897886,ECO:0000269|PubMed:16179649, ECO:0000269|PubMed:18202719,ECO:0000269|PubMed:22903062}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for E2F8_ZNF638 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for E2F8_ZNF638 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| E2F8 | EWSR1, LZTR1, APP, FHL3, TFCP2, ZDHHC17, TTC33 | ZNF638 | WWP1, KIAA1279, CALCOCO2, KRTAP4-12, KRT19, CCDC85B, KRT15, EFEMP2, PLSCR1, HOOK2, SFN, FHL2, SRRM1, ELAVL1, SIRT7, SPP1, CAND1, PURA, YY1, WASL, NELFCD, HECW2, RPA3, RPA2, RPA1, LGR4, PASK, CUL7, OBSL1, EZH2, EED, RNF2, BMI1, LUC7L, SF3A3, IFI16, MED4, HNRNPA1, PPP1CB, PPP1CC, MATR3, MPHOSPH8, SNW1, CDC5L, SSU72, TNFRSF13B, GTF3C2, CLK2, CLEC3A, JPH4, NEUROG3, NOL9, CLK3, BHLHA15, E4F1, APOBEC3D, FEZ1, RBFA, CCDC59, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, SRSF12, SYDE1, AGAP1, CDC25B, CDK16, PPM1H, MAST3, RTKN, FAM110B, DENND4C, USP21, ANKRD34A, FAM53C, MAPKAP1, FAM110A, HDAC4, CGN, TBC1D25, NF1, NADK, CBY1, TIAM1, PHLDB2, KIAA1804, RASAL2, GAB2, MELK, PLEKHA7, CAMSAP2, CDC25C, KIF1C, LPIN3, DEPDC1B, GIGYF2, NAV1, MLLT4, DENND4A, PTPN14, STARD13, SH3BP4, PLEKHA5, RPTOR, EDC3, HDAC7, LARP1, RAB3IP, INPP5E, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for E2F8_ZNF638 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for E2F8_ZNF638 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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