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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10828

FusionGeneSummary for DZIP1L_A4GNT

check button Fusion gene summary
Fusion gene informationFusion gene name: DZIP1L_A4GNT
Fusion gene ID: 10828
HgeneTgene
Gene symbol

DZIP1L

A4GNT

Gene ID

199221

51146

Gene nameDAZ interacting zinc finger protein 1 likealpha-1,4-N-acetylglucosaminyltransferase
SynonymsDZIP2|PKD5alpha4GnT
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein DZIP1LDAZ interacting protein 1-likeDAZ-interacting protein 1-like proteinalpha-1,4-N-acetylglucosaminyltransferase
Modification date2018052320180519
UniProtAcc

Q8IYY4

Q9UNA3

Ensembl transtripts involved in fusion geneENST00000327532, ENST00000488595, 
ENST00000469243, 
ENST00000236709, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: DZIP1L [Title/Abstract] AND A4GNT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneA4GNT

GO:0009101

glycoprotein biosynthetic process

10430883


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1NA-01ADZIP1Lchr3

137831206

-A4GNTchr3

137850124

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000327532ENST00000236709DZIP1Lchr3

137831206

-A4GNTchr3

137850124

-
intron-5UTRENST00000488595ENST00000236709DZIP1Lchr3

137831206

-A4GNTchr3

137850124

-
5UTR-5UTRENST00000469243ENST00000236709DZIP1Lchr3

137831206

-A4GNTchr3

137850124

-

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FusionProtFeatures for DZIP1L_A4GNT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DZIP1L

Q8IYY4

A4GNT

Q9UNA3

Involved in primary cilium formation (PubMed:19852954,PubMed:28530676). Probably acts as a transition zone proteinrequired for localization of PKD1/PC1 and PKD2/PC2 to the ciliarymembrane (PubMed:28530676). {ECO:0000269|PubMed:19852954,ECO:0000269|PubMed:28530676}. Catalyzes the transfer of N-acetylglucosamine (GlcNAc)to core 2 branched O-glycans (PubMed:10430883). Necessary for thesynthesis of type III mucin which is specifically produced in thestomach, duodenum, and pancreatic duct (PubMed:10430883). Mayprotect against inflammation-associated gastric adenocarcinomas(By similarity). {ECO:0000250|UniProtKB:Q14BT6,ECO:0000269|PubMed:10430883}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DZIP1L_A4GNT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DZIP1L_A4GNT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DZIP1LAPP, DAZ1, CEP76, SPERTA4GNTPOMT1, GP1BB, LMF2, POTEF, IMPA2, FAM213A, GLB1L2, PDXDC1, ARF5, FAM69A, TMEM206, BLK, FAM3C, ICK, COMMD3, JMJD8, HOXD13, RNF167, FANK1, ABHD14A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DZIP1L_A4GNT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DZIP1L_A4GNT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource