FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10810

FusionGeneSummary for DYRK1A_MTMR1

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK1A_MTMR1
Fusion gene ID: 10810
HgeneTgene
Gene symbol

DYRK1A

MTMR1

Gene ID

1859

8776

Gene namedual specificity tyrosine phosphorylation regulated kinase 1Amyotubularin related protein 1
SynonymsDYRK|DYRK1|HP86|MNB|MNBH|MRD7-
Cytomap

21q22.13

Xq28

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologsmyotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatase
Modification date2018052220180519
UniProtAcc

Q13627

Q13613

Ensembl transtripts involved in fusion geneENST00000462274, ENST00000338785, 
ENST00000451934, ENST00000321219, 
ENST00000339659, ENST00000398960, 
ENST00000398956, ENST00000455387, 
ENST00000541925, ENST00000542156, 
ENST00000370390, ENST00000451863, 
ENST00000544228, ENST00000445323, 
ENST00000538506, 
Fusion gene scores* DoF score16 X 9 X 10=14405 X 5 X 3=75
# samples 205
** MAII scorelog2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK1A [Title/Abstract] AND MTMR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

HgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

HgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345

TgeneMTMR1

GO:0046856

phosphatidylinositol dephosphorylation

11733541|27018598

TgeneMTMR1

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1M78377DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000462274ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000462274ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000462274ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000338785ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000338785ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000451934ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000451934ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000321219ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000321219ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000339659ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000339659ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398960ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000398960ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000398956ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000398956ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000541925DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000542156DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000370390DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000451863DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000544228DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-3CDSENST00000455387ENST00000445323DYRK1Achr21

38809313

-MTMR1chrX

149895693

+
intron-5UTRENST00000455387ENST00000538506DYRK1Achr21

38809313

-MTMR1chrX

149895693

+

Top

FusionProtFeatures for DYRK1A_MTMR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK1A

Q13627

MTMR1

Q13613

Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. May play a rolein a signaling pathway regulating nuclear functions of cellproliferation. Modulates alternative splicing by phosphorylatingthe splice factor SRSF6 (By similarity). Exhibits a substratepreference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates theapoptotic process. Promotes cell survival upon genotoxic stressthrough phosphorylation of SIRT1. This in turn inhibits TP53activity and apoptosis (By similarity).{ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20,ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067,ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}. Lipid phosphatase that has high specificity forphosphatidylinositol 3-phosphate and has no activity withphosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate(PubMed:11733541, PubMed:27018598). Activity withphosphatidylinositol (3,5)-bisphosphate is controversial; it hasbeen shown by PubMed:27018598, while PubMed:11733541 find noactivity with this substrate. {ECO:0000269|PubMed:11733541,ECO:0000269|PubMed:27018598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DYRK1A_MTMR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DYRK1A_MTMR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DYRK1A_MTMR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DYRK1A_MTMR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource