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Fusion gene ID: 1081 |
FusionGeneSummary for AGAP3_GRM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGAP3_GRM3 | Fusion gene ID: 1081 | Hgene | Tgene | Gene symbol | AGAP3 | GRM3 | Gene ID | 116988 | 2913 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 | glutamate metabotropic receptor 3 | |
| Synonyms | AGAP-3|CENTG3|CRAG|MRIP-1|cnt-g3 | GLUR3|GPRC1C|MGLUR3|mGlu3 | |
| Cytomap | 7q36.1 | 7q21.11-q21.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3CRAM-associated GTPaseCRMP (collapsin response mediator protein) associatedMR1-interacting proteincentaurin-gamma-3 | metabotropic glutamate receptor 3glutamate receptor, metabotropic 3 | |
| Modification date | 20180523 | 20180524 | |
| UniProtAcc | Q96P47 | Q14832 | |
| Ensembl transtripts involved in fusion gene | ENST00000463381, ENST00000473312, ENST00000479901, ENST00000397238, ENST00000476375, ENST00000335367, | ENST00000361669, ENST00000546348, ENST00000536043, ENST00000439827, ENST00000394720, | |
| Fusion gene scores | * DoF score | 10 X 4 X 7=280 | 2 X 2 X 1=4 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: AGAP3 [Title/Abstract] AND GRM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-68-8250-01A | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000463381 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000463381 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000463381 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000463381 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000463381 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000473312 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000473312 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000473312 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000473312 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000473312 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000479901 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000479901 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000479901 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000479901 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000479901 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000397238 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000397238 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| Frame-shift | ENST00000397238 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000397238 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| In-frame | ENST00000397238 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000476375 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000476375 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000476375 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000476375 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000476375 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000335367 | ENST00000361669 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000335367 | ENST00000546348 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000335367 | ENST00000536043 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000335367 | ENST00000439827 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
| intron-3CDS | ENST00000335367 | ENST00000394720 | AGAP3 | chr7 | 150784159 | + | GRM3 | chr7 | 86479686 | + |
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FusionProtFeatures for AGAP3_GRM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGAP3 | GRM3 |
| GTPase-activating protein for the ADP ribosylationfactor family (Potential). GTPase which may be involved in thedegradation of expanded polyglutamine proteins through theubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359,ECO:0000305}. | G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:8840013}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AGAP3_GRM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_207aa MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLI ERIEDLALQNQIREHVISIEGADDNHVHLCQPEWLCGLGLFVCTQGSHHPVSTPEECCHTQTAPQQVQCQWNWDHILSVLCKHVCANGVQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_621nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG >In-frame_AGAP3_ENST00000473312_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG >In-frame_AGAP3_ENST00000479901_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000439827_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG >In-frame_AGAP3_ENST00000397238_chr7_150784159_+_GRM3_ENST00000394720_chr7_86479686_+_647nt ATGAACTTCCAGGCGGGCGGGGGGCAGAGCCCGCAGCAGCAGCAGAGCCTGGCGGCTCCGGGGGGCGGCGGCGCTGCCGCGCAGCAGCTC GTCTGCGGCGGGCAGTTCGGCGGCGCGGGGCCCGGGGCCGGGGGCGGCGGCGGCCCCTCGCAGCAGCTGGCCGGCGGGCCCCCCCAGCAG TTCGCGCTCTCCAACTCCGCGGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCCGTGCATCCCAATATCTACGCCATCTACGACCTGATC GAGCGCATCGAGGATTTGGCGCTGCAGAACCAGATCCGGGAGCACGTCATCTCCATCGAGGGTGCAGACGACAACCATGTGCATCTCTGT CAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGAAGAATGTTGTCACACA CAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCAAGCACGTATGTGCCAACGGTGTGCAA TGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGTTCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTG |
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FusionGenePPI for AGAP3_GRM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AGAP3 | YWHAB, FKBP6, MIER2, HSPB1, NTRK1, HERC2, FLCN, GPR156, ARHGAP22, LZTS2, KBTBD7, JPH4, TSC22D3, NUFIP2, TRIM25 | GRM3 | PPM1A, GRIP1, PICK1, SDCBP, FBXW7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGAP3_GRM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGAP3_GRM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | GRM3 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | GRM3 | C0025202 | melanoma | 2 | CTD_human |
| Tgene | GRM3 | C0525045 | Mood Disorders | 2 | PSYGENET |
| Tgene | GRM3 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | GRM3 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Tgene | GRM3 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | GRM3 | C0858355 | addicted to cocaine | 1 | PSYGENET |
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