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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10799

FusionGeneSummary for DYNLT1_USP15

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNLT1_USP15
Fusion gene ID: 10799
HgeneTgene
Gene symbol

DYNLT1

USP15

Gene ID

6993

9958

Gene namedynein light chain Tctex-type 1ubiquitin specific peptidase 15
SynonymsCW-1|TCTEL1|tctex-1UNPH-2|UNPH4
Cytomap

6q25.3

12q14.1

Type of geneprotein-codingprotein-coding
Descriptiondynein light chain Tctex-type 1T-complex testis-specific protein 1 homologt-complex-associated-testis-expressed 1-like 1ubiquitin carboxyl-terminal hydrolase 15deubiquitinating enzyme 15ubiquitin thioesterase 15ubiquitin thiolesterase 15ubiquitin-specific-processing protease 15
Modification date2018051920180523
UniProtAcc

P63172

Q9Y4E8

Ensembl transtripts involved in fusion geneENST00000367088, ENST00000367089, 
ENST00000367085, 
ENST00000353364, 
ENST00000280377, ENST00000393654, 
ENST00000550632, ENST00000312635, 
Fusion gene scores* DoF score2 X 2 X 2=810 X 8 X 5=400
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYNLT1 [Title/Abstract] AND USP15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP15

GO:0007179

transforming growth factor beta receptor signaling pathway

21947082

TgeneUSP15

GO:0016579

protein deubiquitination

16005295|22344298|27368102

TgeneUSP15

GO:0030509

BMP signaling pathway

21947082

TgeneUSP15

GO:0035520

monoubiquitinated protein deubiquitination

21947082

TgeneUSP15

GO:0035616

histone H2B conserved C-terminal lysine deubiquitination

24526689


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF236714DYNLT1chr6

159058652

-USP15chr12

62698419

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000367088ENST00000353364DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367088ENST00000280377DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367088ENST00000393654DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367088ENST00000550632DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367088ENST00000312635DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367089ENST00000353364DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367089ENST00000280377DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367089ENST00000393654DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367089ENST00000550632DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367089ENST00000312635DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367085ENST00000353364DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367085ENST00000280377DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367085ENST00000393654DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367085ENST00000550632DYNLT1chr6

159058652

-USP15chr12

62698419

+
intron-intronENST00000367085ENST00000312635DYNLT1chr6

159058652

-USP15chr12

62698419

+

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FusionProtFeatures for DYNLT1_USP15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNLT1

P63172

USP15

Q9Y4E8

Acts as one of several non-catalytic accessorycomponents of the cytoplasmic dynein 1 complex that are thought tobe involved in linking dynein to cargos and to adapter proteinsthat regulate dynein function. Cytoplasmic dynein 1 acts as amotor for the intracellular retrograde motility of vesicles andorganelles along microtubules. Binds to transport cargos and isinvolved in apical cargo transport such as rhodopsin-bearingvesicles in polarized epithelia. May also be a accessory componentof axonemal dynein. Plays a role in neuronal morphogenesis; the function isindependent of cytoplasmic dynein and seems to be coupled toregulation of the actin cytoskeleton by enhancing Rac1 activity.The function in neurogenesis may be regulated by association witha G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; theactivation appears to be independent of a nucleotide exchange.Plays a role in regulating neurogenesis; inhibits the genesis ofneurons from precursor cells during cortical developmentpresumably by antagonizing ARHGEF2. Involved in the regulation ofmitotic spindle orientation (By similarity). Unrelated to the rolein retrograde microtubule-associated movement may play a role inthe dimerization of cytoplasmic proteins/domains such as forACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro,inhibits ACVR2B signaling (PubMed:27502274). {ECO:0000250,ECO:0000269|PubMed:27502274}. (Microbial infection) Is involved in intracellulartargeting of D-type retrovirus gag polyproteins to the cytoplasmicassembly site. {ECO:0000269|PubMed:18647839}. Hydrolase that removes conjugated ubiquitin from targetproteins and regulates various pathways such as the TGF-betareceptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways(PubMed:21947082, PubMed:22344298, PubMed:24852371,PubMed:16005295, PubMed:17318178, PubMed:19826004,PubMed:19576224). Acts as a key regulator of TGF-beta receptorsignaling pathway, but the precise mechanism is still unclear:according to a report, acts by promoting deubiquitination ofmonoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), therebyalleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports,regulates the TGF-beta receptor signaling pathway by mediatingdeubiquitination and stabilization of TGFBR1, leading to anenhanced TGF-beta signal (PubMed:22344298). Able to mediatedeubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them againstproteasomal degradation. May also regulate gene expression and/orDNA repair through the deubiquitination of histone H2B(PubMed:24526689). Acts as an inhibitor of mitophagy bycounteracting the action of parkin (PRKN): hydrolyzes cleavage of'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached byparkin on target proteins such as MFN2, thereby reducing parkin'sability to drive mitophagy (PubMed:24852371). Acts as anassociated component of COP9 signalosome complex (CSN) andregulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA anddeubiquitinates substrates bound to VCP (PubMed:16005295,PubMed:17318178, PubMed:19826004, PubMed:19576224). Involved inendosome organization by mediating deubiquitination of SQSTM1:ubiquitinated SQSTM1 forms a molecular bridge that restrainscognate vesicles in the perinuclear region and itsdeubiquitination releases target vesicles for fast transport intothe cell periphery (PubMed:27368102).{ECO:0000269|PubMed:16005295, ECO:0000269|PubMed:17318178,ECO:0000269|PubMed:19576224, ECO:0000269|PubMed:19826004,ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:22344298,ECO:0000269|PubMed:24526689, ECO:0000269|PubMed:24852371,ECO:0000269|PubMed:27368102}. (Microbial infection) Protects APC and humanpapillomavirus type 16 protein E6 against degradation via theubiquitin proteasome pathway. {ECO:0000269|PubMed:19553310}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DYNLT1_USP15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DYNLT1_USP15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DYNLT1_USP15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DYNLT1_USP15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource