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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 1075

FusionGeneSummary for AGAP2_RAB21

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP2_RAB21
Fusion gene ID: 1075
HgeneTgene
Gene symbol

AGAP2

RAB21

Gene ID

116986

23011

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 2RAB21, member RAS oncogene family
SynonymsCENTG1|GGAP2|PIKE-
Cytomap

12q14.1

12q21.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2GTP-binding and GTPase activating protein 2centaurin, gamma 1cnt-g1phosphatidylinositol 3-kinase enhancerphosphoinosiras-related protein Rab-21GTP-binding protein RAB21
Modification date2018052320180523
UniProtAcc

Q99490

Q9UL25

Ensembl transtripts involved in fusion geneENST00000257897, ENST00000547588, 
ENST00000261263, 
Fusion gene scores* DoF score6 X 5 X 3=903 X 3 X 2=18
# samples 63
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AGAP2 [Title/Abstract] AND RAB21 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGAP2

GO:0042177

negative regulation of protein catabolic process

18374643

TgeneRAB21

GO:0017157

regulation of exocytosis

22705394


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-3B-A9HS-01AAGAP2chr12

58123422

-RAB21chr12

72179311

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257897ENST00000261263AGAP2chr12

58123422

-RAB21chr12

72179311

+
In-frameENST00000547588ENST00000261263AGAP2chr12

58123422

-RAB21chr12

72179311

+

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FusionProtFeatures for AGAP2_RAB21


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP2

Q99490

RAB21

Q9UL25

GTPase-activating protein (GAP) for ARF1 and ARF5, whichalso shows strong GTPase activity. Isoform 1 participates in theprevention of neuronal apoptosis by enhancing PI3 kinase activity.It aids the coupling of metabotropic glutamate receptor 1 (GRM1)to cytoplasmic PI3 kinase by interacting with Homer scaffoldingproteins, and also seems to mediate anti-apoptotic effects of NGFby activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3kinase but may protect cells from apoptosis by stimulating Akt. Italso regulates the adapter protein 1 (AP-1)-dependent traffickingof proteins in the endosomal system. It seems to be oncogenic. Itis overexpressed in cancer cells, prevents apoptosis and promotescancer cell invasion. {ECO:0000269|PubMed:12640130,ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108,ECO:0000269|PubMed:16079295}. Regulates integrin internalization and recycling, butdoes not influence the traffic of endosomally translocatedreceptors in general. As a result, may regulate cell adhesion andmigration (By similarity). During the mitosis of adherent cells,controls the endosomal trafficking of integrins which is requiredfor the successful completion of cytokinesis. Involved in neuritegrowth (By similarity). {ECO:0000250,ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318413_420516837Nucleotide bindingGTP
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318457_461516837Nucleotide bindingGTP
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318515_518516837Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318676_910516837DomainPH
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318931_1051516837DomainArf-GAP
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318405_572516837RegionNote=G domain
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-13181090_1119516837RepeatNote=ANK 1
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-13181123_1152516837RepeatNote=ANK 2
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318946_969516837Zinc fingerC4-type
TgeneRAB21chr12:58123422chr12:72179311ENST00000261263+5748_56178226MotifEffector region
TgeneRAB21chr12:58123422chr12:72179311ENST00000261263+57132_135178226Nucleotide bindingNote=GTP
TgeneRAB21chr12:58123422chr12:72179311ENST00000261263+57162_164178226Nucleotide bindingNote=GTP
TgeneRAB21chr12:58123422chr12:72179311ENST00000261263+5726_34178226Nucleotide bindingNote=GTP
TgeneRAB21chr12:58123422chr12:72179311ENST00000261263+5774_78178226Nucleotide bindingGTP


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FusionGeneSequence for AGAP2_RAB21


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AGAP2_ENST00000257897_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_564aa
MHAQRQFVVAAVRAEVRRHEVAKQALNRLRKLAERVDDPELQDSIQASLDSIREAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRF
LTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQ
DRISASSPRVVGDARARALCADMKRCSYTETCATTGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTS
DYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK
KKTVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQ
PPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEGMIETAQVDERAKGNGSSQPGTAR

>In-frame_AGAP2_ENST00000547588_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_900aa
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGTGGAEP
PALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKV
APPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRK
GKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPP
GSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDG
QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMK
RCSYTETCATTGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAV
AGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKTVTLSSNGFLLYHPSINDYIHS
THGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTD
CTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEGMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSGGGCCSSG_


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AGAP2_ENST00000257897_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_1692nt
ATGCATGCCCAGAGGCAGTTCGTTGTAGCTGCAGTGAGAGCAGAAGTCAGACGACATGAGGTGGCCAAGCAGGCTCTAAACCGCCTCAGG
AAGCTGGCAGAGAGGGTGGACGACCCCGAACTCCAGGACAGCATCCAGGCCTCATTGGACAGCATTCGAGAGGCTGTGATCAATAGCCAG
GAATGGACTTTGAGCCGCTCCATTCCTGAACTGCGCCTGGGTGTGCTGGGCGATGCCAGGAGTGGGAAGTCATCGCTCATCCACCGATTC
CTGACTGGCTCATACCAGGTGCTGGAGAAGACAGAGAGTGAGCAGTACAAGAAAGAAATGTTGGTGGATGGACAGACACATCTGGTGCTA
ATCCGAGAGGAAGCTGGGGCACCTGATGCCAAGTTCTCAGGCTGGGCAGATGCTGTGATCTTCGTCTTCAGCCTGGAGGATGAGAACAGT
TTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGAGGCCTGGCCTTGGCACTGGTGGGGACACAA
GACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGCGCGGACATGAAACGCTGCAGCTACTATGAG
ACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTGGTGACCTTGCGCAAGCAGCAACAGCTTCTG
GCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCTGGCCAGGCTAGTAACGGGGGCCACACTAGC
GACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAGGCAGCTGCAGTGGCTGGATTGAGCACCCCA
GGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGTGACTCCGAGAAACGAAGCTTGGATAGTCGG
GGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGAAGTGGCAATTCCTTGAACAAAGAATGGAAG
AAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGATTACATCCACAGTACCCACGGCAAGGAGATG
GACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCCTTTGGCCCCTCAGCCAGCATTAACGGGCTC
GTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCAAGCCCTAGCCCCAGCCCCAGTTCCCTGCAG
CCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCCCTCAGCACGGACTGTACCCCATCTGGAGAC
CTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAAAAATTGACAACACCATCCAAGACTGAAGGC
TCGGCTGGGCAGGCTGAAGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGTCAGCCGGGAACTGCAAGG

>In-frame_AGAP2_ENST00000547588_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_2700nt
ATGAGCCGGGGCGCGGGCGCGCTTCAGCGCCGGACAACGACCTACCTCATCTCGCTGACCCTGGTTAAGCTCGAGTCGGTGCCTCCGCCG
CCGCCTTCTCCGTCTGCGGCCGCGGCCGGCGCCGCCGGTGCCAGAGGCTCCGAGACTGGGGATCCTGGCAGCCCCCGAGGCGCGGAGGAG
CCGGGCAAGAAGCGGCACGAACGTCTCTTCCACCGGCAGGATGCGCTGTGGATCAGCACGAGCAGCGCGGGCACCGGGGGCGCGGAGCCC
CCAGCCCTGTCCCCGGCTCCGGCCAGTCCGGCCCGCCCAGTCTCCCCCGCTCCCGGCCGCCGCCTCTCCCTCTGGGCCGTCCCTCCGGGA
CCCCCGCTCTCCGGGGGACTGAGCCCCGACCCCAAGCCTGGGGGCGCCCCCACCTCCTCCCGGCGCCCCCTGCTCAGCAGCCCGAGCTGG
GGCGGCCCGGAGCCCGAAGGCCGGGCGGGCGGCGGCATCCCTGGCTCATCCTCTCCGCACCCTGGCACCGGCAGCCGGAGGCTCAAGGTG
GCGCCTCCTCCGCCGGCTCCCAAGCCTTGCAAGACCGTGACCACGAGTGGAGCCAAAGCCGGCGGGGGCAAGGGCGCGGGTAGCCGCCTG
TCATGGCCCGAAAGCGAGGGCAAGCCCAGGGTCAAGGGGTCAAAGAGCAGCGCCGGGACTGGAGCTTCGGTCTCTGCCGCCGCCACCGCC
GCCGCCGCCGGGGGAGGGGGCTCTACAGCTTCGACCTCTGGTGGGGTCGGGGCTGGGGCTGGAGCCCGAGGGAAGTTGTCCCCTCGGAAA
GGCAAGAGTAAGACCTTGGACAACAGTGACTTGCATCCGGGACCGCCTGCCGGCTCTCCTCCTCCGCTAACCCTCCCACCAACTCCGAGT
CCAGCCACTGCTGTCACCGCTGCTTCCGCGCAGCCCCCCGGGCCTGCACCTCCAATCACTCTGGAGCCTCCAGCTCCGGGGCTGAAACGG
GGCCGGGAGGGGGGCCGAGCATCCACTCGTGACCGCAAGATGCTCAAGTTTATCAGCGGCATCTTCACCAAGAGCACAGGAGGGCCTCCT
GGCTCCGGGCCCCTTCCCGGACCCCCCAGCCTGTCTTCTGGCAGCGGGTCCAGGGAGCTGCTGGGCGCCGAGCTCCGCGCTTCCCCTAAG
GCTGTGATCAATAGCCAGGAATGGACTTTGAGCCGCTCCATTCCTGAACTGCGCCTGGGTGTGCTGGGCGATGCCAGGAGTGGGAAGTCA
TCGCTCATCCACCGATTCCTGACTGGCTCATACCAGGTGCTGGAGAAGACAGAGAGTGAGCAGTACAAGAAAGAAATGTTGGTGGATGGA
CAGACACATCTGGTGCTAATCCGAGAGGAAGCTGGGGCACCTGATGCCAAGTTCTCAGGCTGGGCAGATGCTGTGATCTTCGTCTTCAGC
CTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGAGGCCTGGCCTTG
GCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGCGCGGACATGAAA
CGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTGGTGACCTTGCGC
AAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCTGGCCAGGCTAGT
AACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAGGCAGCTGCAGTG
GCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGTGACTCCGAGAAA
CGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGAAGTGGCAATTCC
TTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGATTACATCCACAGT
ACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCCTTTGGCCCCTCA
GCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCAAGCCCTAGCCCC
AGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCCCTCAGCACGGAC
TGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAAAAATTGACAACA
CCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGT
CAGCCGGGAACTGCAAGGCGAGGTGTACAGATTATTGATGATGAACCTCAAGCCCAGACCAGTGGTGGAGGGTGCTGTTCTTCTGGATAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_AGAP2_ENST00000257897_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_7024nt
GGGGCCTTCTGAGGTTTGGGGGCTGTAGGGCCATGGGCCTCAGGGCCAGAGGTGGTTGTTAGCCTGGCAAGACAGGTCTGGGCAACATGC
ATGCCCAGAGGCAGTTCGTTGTAGCTGCAGTGAGAGCAGAAGTCAGACGACATGAGGTGGCCAAGCAGGCTCTAAACCGCCTCAGGAAGC
TGGCAGAGAGGGTGGACGACCCCGAACTCCAGGACAGCATCCAGGCCTCATTGGACAGCATTCGAGAGGCTGTGATCAATAGCCAGGAAT
GGACTTTGAGCCGCTCCATTCCTGAACTGCGCCTGGGTGTGCTGGGCGATGCCAGGAGTGGGAAGTCATCGCTCATCCACCGATTCCTGA
CTGGCTCATACCAGGTGCTGGAGAAGACAGAGAGTGAGCAGTACAAGAAAGAAATGTTGGTGGATGGACAGACACATCTGGTGCTAATCC
GAGAGGAAGCTGGGGCACCTGATGCCAAGTTCTCAGGCTGGGCAGATGCTGTGATCTTCGTCTTCAGCCTGGAGGATGAGAACAGTTTCC
AGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGAGGCCTGGCCTTGGCACTGGTGGGGACACAAGACA
GGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGCGCGGACATGAAACGCTGCAGCTACTATGAGACTT
GTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTGGTGACCTTGCGCAAGCAGCAACAGCTTCTGGCTG
CCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCTGGCCAGGCTAGTAACGGGGGCCACACTAGCGACT
ACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAGGCAGCTGCAGTGGCTGGATTGAGCACCCCAGGGT
CCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGTGACTCCGAGAAACGAAGCTTGGATAGTCGGGGAG
AGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGAAGTGGCAATTCCTTGAACAAAGAATGGAAGAAGA
AATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGATTACATCCACAGTACCCACGGCAAGGAGATGGACT
TGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCCTTTGGCCCCTCAGCCAGCATTAACGGGCTCGTCA
AGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCAAGCCCTAGCCCCAGCCCCAGTTCCCTGCAGCCAC
CACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCCCTCAGCACGGACTGTACCCCATCTGGAGACCTGA
GCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAAAAATTGACAACACCATCCAAGACTGAAGGCTCGG
CTGGGCAGGCTGAAGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGTCAGCCGGGAACTGCAAGGCGAG
GTGTACAGATTATTGATGATGAACCTCAAGCCCAGACCAGTGGTGGAGGGTGCTGTTCTTCTGGATAACTGTTCACGCCTAAGAAATTAA
AAGACAGAACAAAACTGTGGATCATTGCCCTCAACATGAAGACTGCCATATTCCAAGTCACATTATTTTACCAATGGAATTATAGAATTA
ACAGTATTTTAAATTACGTTTATAACACTGCAGAGACCTTAAGTGCTAAACTTAGTGGAGTTTGTGACCAGAGAATTGGCATTTTCTACA
AATGTTTTTTTTTGTTTTTTTTTTGTTTTTTTTTGTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCACTGGCTTG
ATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTATAGGCGCCCACCAC
GACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAGGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCCGC
CCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTACAAATGTTAACAAAGCAATTACCAATGGCCTTT
TTACATATTTTTTCTTTAATGAGGAATAATATGCATGTAGAAAAGACCTACTTAAAGTCTTCATTTATATTCTTTCAAATCAAATCTTTA
TTTAATAACTTATATATGTTGTTGGAATGGTTACATTTTTGCAGCCCTTTGTATTTTGTGGTAGTTGAAATTGTATCACTTCTAAACAGC
AAACTGTTTTTGTTTTTAATTAGCAGATATCTGAAGTACTATTTTTGCAGGGTTTGCACAGGCCCGTAACTGTCTACTACTTTGATATAA
TCTGTATACATCCTGTATGCTGAGCTGGTAAAATACATTGTAAATTACATATTAAATATTTTATCTGCTTTTACAAGCGCAAGGTGCAAA
AATATATACAATAGTCTCATTGATGACTGTAAAGTGAATTAACATTTGGTGATTATGCCTAGCTTTTTTGACTAATATAAAGATCATAGC
TCCCCTTCACTTCTGTCTTAACTTGAACATGGCGTGTTTAAATTTTCATACATACTTTACTTGAATTATTGCTGTTGTCACATATTTTTG
CCTCTGTGAGTTCATCTGATGATTGAGCAGTAGCATTTGCCTTTTGGGTTTTTTGTTTGTTATTATAGAAGAGATGACTTCTGCTGATTT
TGCTTTAGAATGGTTACCTTAGAAGAATTTGGGTGGCTCATGTTGAATTTCACTTCTGCAATAGCTTTCATTTTCTCATAGGCTTTATAA
GAGATGGGTTCAGTGGTATGAGCAGAGGAAGAGATCCCAGATAGTAGCCAGTTAACCAAGACTCATTCATATAGCACGTAGTTTATGTTC
CTGAGGCAGCACTTTTAGATCCTTTGTGAGCAAGTTCTATTTGTTCATTGCTTGCCAGAGATGAACACAGAATGTTCTGTTTCATTTTAC
AAGAACTATCCTGAGTTTCTGTGGATGGAAACATTACATGTAATGCAGATATAGTGAACACTGGAAAGATTTATTAAAGAATTATATTTG
TGTATACTTTATAAATTAGTCCCTCATTAGATTTTTTTTTCTTAAGCATAAGACTGAACTTAAATGTGTTAATTTTAGTAGAATCAGGCA
CTGCTCGCAGAAGGAACACAGATTGTAGAGATTAACATAAATTGTTCTTGTTCTAATATATATATTTTTTCATTTCTGTCGTGCTTGGAA
AACTAGTAAATATTATGTCTAAGATAAAATGGAATGGCCCCTGGATTTACTTCTTATAAGAAGCAGTAGTATGTAATAAAGCTATTAGCA
TGAGCAATTAAGAGGCTATAAAGAGATTATAGTTACAAAAGAAATACTGCCATATTTTTAAGTTAATAACTTAAACCTTCTCAAATGGGT
TAAAAGTTGAATGAATTGACACCCTGATGTTATGATGTTGGAATTTTAACTTAAACTGGGAGGCATTCTGTGAGCCTTCACTTTACCTTC
TTTAATTATTGTCCTTGCTAAACTCAACACAGACTTTTCTGTTATGTGTTTTTGAGGAAGTTGGGGTGGGAAGAGTCAGGGAGATAAGCT
AAAATTGTCTTCTTTTATGGGGTAATTGTACTCTGTAGTCTCTTGGTTTCCTGTGAAGTTAGTATTTATGTGGGGGTGGGGGAAGGTAGC
AAGAATCATGGGTATCACGGTACTTTGTTTTTGACCTCCTGGCTCTTTCAGACAGAGTGAAGAAAGCTTTTCCATTCTTACTGTTGTAGA
AGTAGATAGGAAATAAGCTTTTCTCATTACAGTGAAATATGTTTTAAAAACTAGAGTAGCTGGGCACAGAGGCATGCATTTGTAGGGCCA
GCTACTTGGGAGAGTGAGGCAGGAGGATCACTTGAGGCCAGGATTTCAAATCCAGCCTAGGTAACACTGAGACCTCCATCTCGTAAAAGG
CACAAAAACTAGTTAGAGATGAAATTGAGCTTTATTTTAAAAAAACGTTCTAAAGCCTGATAATTGGAGAGCTATACTTCAGCTTTTCAT
CCTACTTTAATGAAACAGCTAGATAGGAACCTCTGCTCCAGAATTGCCAGATAATTATTGGTGGGTCATAACTATTCTTCATATTTTTTT
TTTCTTTTTTCTCCTTTGGTTTCTGTGTTATCTTTCTTAACCTCACGTATTTCTTTATCCTTTTTAGTGGGGGCCTGTAATTGAGGCTAA
TTCAATAGCAACAATAGACAACATGATATGGCTGCTGTCACTTTGAAACCCAAAAGGTCTTTGGGTAGGAATAGAGTAATGAAAGAGGAC
CAGTCAACTTCAGTATATATACAAAGGAAAGACAAAGAGATGATAAACCAAGGCTGAGGAAATTTTTCTGATGCTTTCTTCATTTCTCTA
ATATACCTTTTGCATTCTTTTTCTGATAATTGTGCTATTAGGCAGAAGACACAAGTTACCACGTTGTGTATTAAAAGCAGTAGGTAGGTT
GTGCCAGTATTTTTTCAGCCAGTAAGCATATACAGTTAACTTATATAATTAAAAATTGGTTTAAGATAGTGATTAAAAATACCTGAATAT
TATGTTAAAAGTATACAATCATTGTTTCTGTAATGATGATGGGTATTCTGCTTCTTGTTTTTCATTGTAATTACAGGGGAAGATTGTTTT
TGAAAATGTATATTGCCATGCTTTTGGGGTAAGCAGTAATGTGAAAAGAAAAAAGCATTATGTTATTGTATGAAATATAAGTGTTCAGAT
TTGTTTTGTCTGGGGTGTTGCCTAAGAATACCCTAAAGCTATGGCTGTTACTGCATTGAAATCTTTTTTTTTTTTAATAGTAGCCATATG
TTATTAGTGGAGTACTTTATATTTGACATTAAAGTGAAGAAGAAGAGTAGTACTTCACTTTTAGGTTTTTAGTAGTGAAAGATAAAATTG
GAAAAATAGGGAAAGAGCATAGGGAGGAATAGAATGGAAGTCAAGTAAATAAAAAACTACAACCTGACAGTTTTTTAAATCACTTTGAAA
AGTACATTACTTTTATCAAAGAGTTTCTAATTAAGGCAAACTATGCATTATGCCAAATATTAAGAACATTTTAAAAATGGATTGTGATAC
TGTTTATTTCTTTAATTATATAATTTGCAATTTTCTGTATTATAAGTGCTACCAGGATTCTAGATAGTTGATCTTACATATTCAGATAGT
ATAGTTTACTCTTATAATTACCCGTTACGTTATCTCTAAAAGTAGTTTGATCTGTGCCTTTAACTTTTAGAATTCATCTTTTGACTTGTT
TGCCACTGTAGAGTTTTCAGTTTTCTCTGTAGATTCAGTGTGACAAAGAGGGAATACATAATTTGTGACCATTTAAGATGCTGATATTTT
CTGGAAAAGGATATAGATAGTAGTAGTGACCCGCAGGAGCCTCACAATAATGTCTAAAGATATAAACTGAGTAGATCCCTAAGTACTCTT
CTCTAAATTATAAAATGCATTACCTAGGCTTTAATAGTTAAAAGCTGGAATTTATTGAACCGCATCTACTTGATTTCATAATATGCATTG
ATTTTAGTATGTTGCTGTTCTGTTATCTGTAATCAACTATAACAGAGTAATATATTTGGTGTTCTGGACCAAAATTCGTGCTACACATAT
GTCTGATGGCCTTTACCTTTTCAAGAAAACAGTTGCAATTTTGAGCAAAATTTTCCTAGTTGTAATATTTTAATAGTGTTATGTATTGGA
AAAAATTTAGAAATACTCCTAAGAGTTTTCAATTTCAAGCAGAAATGCTTCTCTTCTAAATAAATACCACTTAATTGATAGACCTTTAGC
AGTTCTTGTGCTATCTAGGATTTATACATTTTTGCTTTTCTGGAAAACTGCTTTGGCGCATTAACCTTTCTACTGCAACATTTTCTCTTC
AGTAGATATATGAGTAAACATGATGAGTTAATGTTACACAGCATACCCAGTTAGGTCTCTTATTCTTAAAGCATCTTTCTTTAGAAGTCT
GCACATATTTTCAAATGCATCATATTAAAGGCACAAGTCAAGAGGAGGTGGAGTTGCCTACTTCAGTGGCCTTTATTCCCACTATACCAG
TTCTCAGTCTTGATTTTGATACTTTCTGGCAACTGTATCATCTCTTCACTATCACGTATTTTAAGAAAAAGCTAAGGTGATTTCTTTACA
TTTGAACATGTGTAGATCAATGAGAGAATGGTGAGGGATAGCAAGGATAAAGTATAATGTTGAAAAGTAGAAAGAAGTGGTATCTGCTAA
ACTCTAGCTTTAGTAGCAAGCTATTTTAAGGAAATCATTGTATGTGGTACTTCCTAGAAATATGAAAGTTCCTCATTTTGTATTTAATTA
TGTAAGAAAATGTTCTAGGAAAAGAATAAAAAACATATATTGTCAAAGTGCCCTTTGGTAGTGCTCCCAAATGGTAGTAACTATTGGTCT
CTAGTATATACTCCTCAAATATCTTTTTGCTATGTATTAATATATCTATATGTTTACATATAGAAATACATAGTGTTGTGGGTTTTAAAT
TTTCACATAAATTGTGTCTTACCCATGTGTTTTGCCATTTGCCTTTTCTCTTGCCAACGTGTCTAGGAGCTCTTTGGTAAATACAGACTT
TTTCATTTTATTTCCTCCCACATTTCTATGGATGTGTCTTGCCTTTTTCTTTTTTTTTTCTTTCTTTTTTTCTTTTTTAAAATAGCCTCT

>In-frame_AGAP2_ENST00000547588_chr12_58123422_-_RAB21_ENST00000261263_chr12_72179311_+_7946nt
ATGAGCCGGGGCGCGGGCGCGCTTCAGCGCCGGACAACGACCTACCTCATCTCGCTGACCCTGGTTAAGCTCGAGTCGGTGCCTCCGCCG
CCGCCTTCTCCGTCTGCGGCCGCGGCCGGCGCCGCCGGTGCCAGAGGCTCCGAGACTGGGGATCCTGGCAGCCCCCGAGGCGCGGAGGAG
CCGGGCAAGAAGCGGCACGAACGTCTCTTCCACCGGCAGGATGCGCTGTGGATCAGCACGAGCAGCGCGGGCACCGGGGGCGCGGAGCCC
CCAGCCCTGTCCCCGGCTCCGGCCAGTCCGGCCCGCCCAGTCTCCCCCGCTCCCGGCCGCCGCCTCTCCCTCTGGGCCGTCCCTCCGGGA
CCCCCGCTCTCCGGGGGACTGAGCCCCGACCCCAAGCCTGGGGGCGCCCCCACCTCCTCCCGGCGCCCCCTGCTCAGCAGCCCGAGCTGG
GGCGGCCCGGAGCCCGAAGGCCGGGCGGGCGGCGGCATCCCTGGCTCATCCTCTCCGCACCCTGGCACCGGCAGCCGGAGGCTCAAGGTG
GCGCCTCCTCCGCCGGCTCCCAAGCCTTGCAAGACCGTGACCACGAGTGGAGCCAAAGCCGGCGGGGGCAAGGGCGCGGGTAGCCGCCTG
TCATGGCCCGAAAGCGAGGGCAAGCCCAGGGTCAAGGGGTCAAAGAGCAGCGCCGGGACTGGAGCTTCGGTCTCTGCCGCCGCCACCGCC
GCCGCCGCCGGGGGAGGGGGCTCTACAGCTTCGACCTCTGGTGGGGTCGGGGCTGGGGCTGGAGCCCGAGGGAAGTTGTCCCCTCGGAAA
GGCAAGAGTAAGACCTTGGACAACAGTGACTTGCATCCGGGACCGCCTGCCGGCTCTCCTCCTCCGCTAACCCTCCCACCAACTCCGAGT
CCAGCCACTGCTGTCACCGCTGCTTCCGCGCAGCCCCCCGGGCCTGCACCTCCAATCACTCTGGAGCCTCCAGCTCCGGGGCTGAAACGG
GGCCGGGAGGGGGGCCGAGCATCCACTCGTGACCGCAAGATGCTCAAGTTTATCAGCGGCATCTTCACCAAGAGCACAGGAGGGCCTCCT
GGCTCCGGGCCCCTTCCCGGACCCCCCAGCCTGTCTTCTGGCAGCGGGTCCAGGGAGCTGCTGGGCGCCGAGCTCCGCGCTTCCCCTAAG
GCTGTGATCAATAGCCAGGAATGGACTTTGAGCCGCTCCATTCCTGAACTGCGCCTGGGTGTGCTGGGCGATGCCAGGAGTGGGAAGTCA
TCGCTCATCCACCGATTCCTGACTGGCTCATACCAGGTGCTGGAGAAGACAGAGAGTGAGCAGTACAAGAAAGAAATGTTGGTGGATGGA
CAGACACATCTGGTGCTAATCCGAGAGGAAGCTGGGGCACCTGATGCCAAGTTCTCAGGCTGGGCAGATGCTGTGATCTTCGTCTTCAGC
CTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGAGGCCTGGCCTTG
GCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGCGCGGACATGAAA
CGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTGGTGACCTTGCGC
AAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCTGGCCAGGCTAGT
AACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAGGCAGCTGCAGTG
GCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGTGACTCCGAGAAA
CGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGAAGTGGCAATTCC
TTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGATTACATCCACAGT
ACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCCTTTGGCCCCTCA
GCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCAAGCCCTAGCCCC
AGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCCCTCAGCACGGAC
TGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAAAAATTGACAACA
CCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGGGATGATAGAAACAGCACAAGTGGATGAGAGAGCAAAAGGCAATGGCTCTAGT
CAGCCGGGAACTGCAAGGCGAGGTGTACAGATTATTGATGATGAACCTCAAGCCCAGACCAGTGGTGGAGGGTGCTGTTCTTCTGGATAA
CTGTTCACGCCTAAGAAATTAAAAGACAGAACAAAACTGTGGATCATTGCCCTCAACATGAAGACTGCCATATTCCAAGTCACATTATTT
TACCAATGGAATTATAGAATTAACAGTATTTTAAATTACGTTTATAACACTGCAGAGACCTTAAGTGCTAAACTTAGTGGAGTTTGTGAC
CAGAGAATTGGCATTTTCTACAAATGTTTTTTTTTGTTTTTTTTTTGTTTTTTTTTGTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACC
CAGGCTGGAGTGCACTGGCTTGATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGC
TGGGACTATAGGCGCCCACCACGACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCAGGTTAGCCAGGATGGTCTCG
ATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTACAAATGTTAAC
AAAGCAATTACCAATGGCCTTTTTACATATTTTTTCTTTAATGAGGAATAATATGCATGTAGAAAAGACCTACTTAAAGTCTTCATTTAT
ATTCTTTCAAATCAAATCTTTATTTAATAACTTATATATGTTGTTGGAATGGTTACATTTTTGCAGCCCTTTGTATTTTGTGGTAGTTGA
AATTGTATCACTTCTAAACAGCAAACTGTTTTTGTTTTTAATTAGCAGATATCTGAAGTACTATTTTTGCAGGGTTTGCACAGGCCCGTA
ACTGTCTACTACTTTGATATAATCTGTATACATCCTGTATGCTGAGCTGGTAAAATACATTGTAAATTACATATTAAATATTTTATCTGC
TTTTACAAGCGCAAGGTGCAAAAATATATACAATAGTCTCATTGATGACTGTAAAGTGAATTAACATTTGGTGATTATGCCTAGCTTTTT
TGACTAATATAAAGATCATAGCTCCCCTTCACTTCTGTCTTAACTTGAACATGGCGTGTTTAAATTTTCATACATACTTTACTTGAATTA
TTGCTGTTGTCACATATTTTTGCCTCTGTGAGTTCATCTGATGATTGAGCAGTAGCATTTGCCTTTTGGGTTTTTTGTTTGTTATTATAG
AAGAGATGACTTCTGCTGATTTTGCTTTAGAATGGTTACCTTAGAAGAATTTGGGTGGCTCATGTTGAATTTCACTTCTGCAATAGCTTT
CATTTTCTCATAGGCTTTATAAGAGATGGGTTCAGTGGTATGAGCAGAGGAAGAGATCCCAGATAGTAGCCAGTTAACCAAGACTCATTC
ATATAGCACGTAGTTTATGTTCCTGAGGCAGCACTTTTAGATCCTTTGTGAGCAAGTTCTATTTGTTCATTGCTTGCCAGAGATGAACAC
AGAATGTTCTGTTTCATTTTACAAGAACTATCCTGAGTTTCTGTGGATGGAAACATTACATGTAATGCAGATATAGTGAACACTGGAAAG
ATTTATTAAAGAATTATATTTGTGTATACTTTATAAATTAGTCCCTCATTAGATTTTTTTTTCTTAAGCATAAGACTGAACTTAAATGTG
TTAATTTTAGTAGAATCAGGCACTGCTCGCAGAAGGAACACAGATTGTAGAGATTAACATAAATTGTTCTTGTTCTAATATATATATTTT
TTCATTTCTGTCGTGCTTGGAAAACTAGTAAATATTATGTCTAAGATAAAATGGAATGGCCCCTGGATTTACTTCTTATAAGAAGCAGTA
GTATGTAATAAAGCTATTAGCATGAGCAATTAAGAGGCTATAAAGAGATTATAGTTACAAAAGAAATACTGCCATATTTTTAAGTTAATA
ACTTAAACCTTCTCAAATGGGTTAAAAGTTGAATGAATTGACACCCTGATGTTATGATGTTGGAATTTTAACTTAAACTGGGAGGCATTC
TGTGAGCCTTCACTTTACCTTCTTTAATTATTGTCCTTGCTAAACTCAACACAGACTTTTCTGTTATGTGTTTTTGAGGAAGTTGGGGTG
GGAAGAGTCAGGGAGATAAGCTAAAATTGTCTTCTTTTATGGGGTAATTGTACTCTGTAGTCTCTTGGTTTCCTGTGAAGTTAGTATTTA
TGTGGGGGTGGGGGAAGGTAGCAAGAATCATGGGTATCACGGTACTTTGTTTTTGACCTCCTGGCTCTTTCAGACAGAGTGAAGAAAGCT
TTTCCATTCTTACTGTTGTAGAAGTAGATAGGAAATAAGCTTTTCTCATTACAGTGAAATATGTTTTAAAAACTAGAGTAGCTGGGCACA
GAGGCATGCATTTGTAGGGCCAGCTACTTGGGAGAGTGAGGCAGGAGGATCACTTGAGGCCAGGATTTCAAATCCAGCCTAGGTAACACT
GAGACCTCCATCTCGTAAAAGGCACAAAAACTAGTTAGAGATGAAATTGAGCTTTATTTTAAAAAAACGTTCTAAAGCCTGATAATTGGA
GAGCTATACTTCAGCTTTTCATCCTACTTTAATGAAACAGCTAGATAGGAACCTCTGCTCCAGAATTGCCAGATAATTATTGGTGGGTCA
TAACTATTCTTCATATTTTTTTTTTCTTTTTTCTCCTTTGGTTTCTGTGTTATCTTTCTTAACCTCACGTATTTCTTTATCCTTTTTAGT
GGGGGCCTGTAATTGAGGCTAATTCAATAGCAACAATAGACAACATGATATGGCTGCTGTCACTTTGAAACCCAAAAGGTCTTTGGGTAG
GAATAGAGTAATGAAAGAGGACCAGTCAACTTCAGTATATATACAAAGGAAAGACAAAGAGATGATAAACCAAGGCTGAGGAAATTTTTC
TGATGCTTTCTTCATTTCTCTAATATACCTTTTGCATTCTTTTTCTGATAATTGTGCTATTAGGCAGAAGACACAAGTTACCACGTTGTG
TATTAAAAGCAGTAGGTAGGTTGTGCCAGTATTTTTTCAGCCAGTAAGCATATACAGTTAACTTATATAATTAAAAATTGGTTTAAGATA
GTGATTAAAAATACCTGAATATTATGTTAAAAGTATACAATCATTGTTTCTGTAATGATGATGGGTATTCTGCTTCTTGTTTTTCATTGT
AATTACAGGGGAAGATTGTTTTTGAAAATGTATATTGCCATGCTTTTGGGGTAAGCAGTAATGTGAAAAGAAAAAAGCATTATGTTATTG
TATGAAATATAAGTGTTCAGATTTGTTTTGTCTGGGGTGTTGCCTAAGAATACCCTAAAGCTATGGCTGTTACTGCATTGAAATCTTTTT
TTTTTTTAATAGTAGCCATATGTTATTAGTGGAGTACTTTATATTTGACATTAAAGTGAAGAAGAAGAGTAGTACTTCACTTTTAGGTTT
TTAGTAGTGAAAGATAAAATTGGAAAAATAGGGAAAGAGCATAGGGAGGAATAGAATGGAAGTCAAGTAAATAAAAAACTACAACCTGAC
AGTTTTTTAAATCACTTTGAAAAGTACATTACTTTTATCAAAGAGTTTCTAATTAAGGCAAACTATGCATTATGCCAAATATTAAGAACA
TTTTAAAAATGGATTGTGATACTGTTTATTTCTTTAATTATATAATTTGCAATTTTCTGTATTATAAGTGCTACCAGGATTCTAGATAGT
TGATCTTACATATTCAGATAGTATAGTTTACTCTTATAATTACCCGTTACGTTATCTCTAAAAGTAGTTTGATCTGTGCCTTTAACTTTT
AGAATTCATCTTTTGACTTGTTTGCCACTGTAGAGTTTTCAGTTTTCTCTGTAGATTCAGTGTGACAAAGAGGGAATACATAATTTGTGA
CCATTTAAGATGCTGATATTTTCTGGAAAAGGATATAGATAGTAGTAGTGACCCGCAGGAGCCTCACAATAATGTCTAAAGATATAAACT
GAGTAGATCCCTAAGTACTCTTCTCTAAATTATAAAATGCATTACCTAGGCTTTAATAGTTAAAAGCTGGAATTTATTGAACCGCATCTA
CTTGATTTCATAATATGCATTGATTTTAGTATGTTGCTGTTCTGTTATCTGTAATCAACTATAACAGAGTAATATATTTGGTGTTCTGGA
CCAAAATTCGTGCTACACATATGTCTGATGGCCTTTACCTTTTCAAGAAAACAGTTGCAATTTTGAGCAAAATTTTCCTAGTTGTAATAT
TTTAATAGTGTTATGTATTGGAAAAAATTTAGAAATACTCCTAAGAGTTTTCAATTTCAAGCAGAAATGCTTCTCTTCTAAATAAATACC
ACTTAATTGATAGACCTTTAGCAGTTCTTGTGCTATCTAGGATTTATACATTTTTGCTTTTCTGGAAAACTGCTTTGGCGCATTAACCTT
TCTACTGCAACATTTTCTCTTCAGTAGATATATGAGTAAACATGATGAGTTAATGTTACACAGCATACCCAGTTAGGTCTCTTATTCTTA
AAGCATCTTTCTTTAGAAGTCTGCACATATTTTCAAATGCATCATATTAAAGGCACAAGTCAAGAGGAGGTGGAGTTGCCTACTTCAGTG
GCCTTTATTCCCACTATACCAGTTCTCAGTCTTGATTTTGATACTTTCTGGCAACTGTATCATCTCTTCACTATCACGTATTTTAAGAAA
AAGCTAAGGTGATTTCTTTACATTTGAACATGTGTAGATCAATGAGAGAATGGTGAGGGATAGCAAGGATAAAGTATAATGTTGAAAAGT
AGAAAGAAGTGGTATCTGCTAAACTCTAGCTTTAGTAGCAAGCTATTTTAAGGAAATCATTGTATGTGGTACTTCCTAGAAATATGAAAG
TTCCTCATTTTGTATTTAATTATGTAAGAAAATGTTCTAGGAAAAGAATAAAAAACATATATTGTCAAAGTGCCCTTTGGTAGTGCTCCC
AAATGGTAGTAACTATTGGTCTCTAGTATATACTCCTCAAATATCTTTTTGCTATGTATTAATATATCTATATGTTTACATATAGAAATA
CATAGTGTTGTGGGTTTTAAATTTTCACATAAATTGTGTCTTACCCATGTGTTTTGCCATTTGCCTTTTCTCTTGCCAACGTGTCTAGGA
GCTCTTTGGTAAATACAGACTTTTTCATTTTATTTCCTCCCACATTTCTATGGATGTGTCTTGCCTTTTTCTTTTTTTTTTCTTTCTTTT


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FusionGenePPI for AGAP2_RAB21


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGAP2HOMER1, EPB41L1, PIK3R1, NF2, MPRIP, GRIP1, GRIA2, CDC42, RAC1, RAC2, RHOA, ARF1, AKT1RAB21ELAVL1, RABGEF1, LAMTOR3, HNRNPF, APPL1, CUL7, VSIG2, MCM2, GDI1, SLC22A16, FANCE, RAB2B, VAC14, VIPR2, DPAGT1, C16orf58, P2RX1, FUCA2, HCCS, GBA, SDHA, SOD1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-13181_23516837EPB41L1
HgeneAGAP2chr12:58123422chr12:72179311ENST00000257897-1318267_390516837PLCG1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGAP2_RAB21


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGAP2_RAB21


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource