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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1073

FusionGeneSummary for AGAP2_IL11

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP2_IL11
Fusion gene ID: 1073
HgeneTgene
Gene symbol

AGAP2

IL11

Gene ID

116986

3589

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 2interleukin 11
SynonymsCENTG1|GGAP2|PIKEAGIF|IL-11
Cytomap

12q14.1

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2GTP-binding and GTPase activating protein 2centaurin, gamma 1cnt-g1phosphatidylinositol 3-kinase enhancerphosphoinosiinterleukin-11adipogenesis inhibitory factoroprelvekin
Modification date2018052320180523
UniProtAcc

Q99490

P20809

Ensembl transtripts involved in fusion geneENST00000257897, ENST00000547588, 
ENST00000264563, ENST00000590625, 
ENST00000585513, 
Fusion gene scores* DoF score6 X 5 X 3=901 X 1 X 1=1
# samples 61
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: AGAP2 [Title/Abstract] AND IL11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAGAP2

GO:0042177

negative regulation of protein catabolic process

18374643

TgeneIL11

GO:0008284

positive regulation of cell proliferation

2145578

TgeneIL11

GO:0033138

positive regulation of peptidyl-serine phosphorylation

7508917

TgeneIL11

GO:0043410

positive regulation of MAPK cascade

7508917

TgeneIL11

GO:0045944

positive regulation of transcription by RNA polymerase II

7508917

TgeneIL11

GO:0046888

negative regulation of hormone secretion

7867561

TgeneIL11

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

7508917


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM893846AGAP2chr12

58122051

-IL11chr19

55877003

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000257897ENST00000264563AGAP2chr12

58122051

-IL11chr19

55877003

+
intron-3UTRENST00000257897ENST00000590625AGAP2chr12

58122051

-IL11chr19

55877003

+
intron-3UTRENST00000257897ENST00000585513AGAP2chr12

58122051

-IL11chr19

55877003

+
intron-3UTRENST00000547588ENST00000264563AGAP2chr12

58122051

-IL11chr19

55877003

+
intron-3UTRENST00000547588ENST00000590625AGAP2chr12

58122051

-IL11chr19

55877003

+
intron-3UTRENST00000547588ENST00000585513AGAP2chr12

58122051

-IL11chr19

55877003

+

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FusionProtFeatures for AGAP2_IL11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP2

Q99490

IL11

P20809

GTPase-activating protein (GAP) for ARF1 and ARF5, whichalso shows strong GTPase activity. Isoform 1 participates in theprevention of neuronal apoptosis by enhancing PI3 kinase activity.It aids the coupling of metabotropic glutamate receptor 1 (GRM1)to cytoplasmic PI3 kinase by interacting with Homer scaffoldingproteins, and also seems to mediate anti-apoptotic effects of NGFby activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3kinase but may protect cells from apoptosis by stimulating Akt. Italso regulates the adapter protein 1 (AP-1)-dependent traffickingof proteins in the endosomal system. It seems to be oncogenic. Itis overexpressed in cancer cells, prevents apoptosis and promotescancer cell invasion. {ECO:0000269|PubMed:12640130,ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108,ECO:0000269|PubMed:16079295}. Cytokine that stimulates the proliferation ofhematopoietic stem cells and megakaryocyte progenitor cells andinduces megakaryocyte maturation resulting in increased plateletproduction (PubMed:2145578). Also promotes the proliferation ofhepatocytes in response to liver damage. Binding to its receptorformed by IL6ST and either IL11RA1 or IL11RA2 activates asignaling cascade that promotes cell proliferation(PubMed:12919066). Signaling leads to the activation ofintracellular protein kinases and the phosphorylation of STAT3.{ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066,ECO:0000269|PubMed:2145578}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AGAP2_IL11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AGAP2_IL11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AGAP2_IL11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AGAP2_IL11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL11C0000786Spontaneous abortion1CTD_human
TgeneIL11C0010692Cystitis1CTD_human
TgeneIL11C0013604Edema1CTD_human
TgeneIL11C0019080Hemorrhage1CTD_human
TgeneIL11C0023895Liver diseases1CTD_human
TgeneIL11C0041696Unipolar Depression1PSYGENET
TgeneIL11C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneIL11C1269683Major Depressive Disorder1PSYGENET
TgeneIL11C4277682Chemical and Drug Induced Liver Injury1CTD_human