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Fusion gene ID: 10728 |
FusionGeneSummary for DVL2_TMEM256 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DVL2_TMEM256 | Fusion gene ID: 10728 | Hgene | Tgene | Gene symbol | DVL2 | TMEM256 | Gene ID | 1856 | 254863 |
| Gene name | dishevelled segment polarity protein 2 | transmembrane protein 256 | |
| Synonyms | - | C17orf61 | |
| Cytomap | 17p13.1 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | segment polarity protein dishevelled homolog DVL-2dishevelled 2 (homologous to Drosophila dsh)dishevelled, dsh homolog 2 | transmembrane protein 256UPF0451 protein C17orf61 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O14641 | Q8N2U0 | |
| Ensembl transtripts involved in fusion gene | ENST00000005340, ENST00000575458, ENST00000574642, | ENST00000302422, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 3 X 2 X 2=12 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DVL2 [Title/Abstract] AND TMEM256 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DVL2 | GO:0006366 | transcription by RNA polymerase II | 11742073 |
| Hgene | DVL2 | GO:0043507 | positive regulation of JUN kinase activity | 17593335 |
| Hgene | DVL2 | GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation | 18787224 |
| Hgene | DVL2 | GO:0045893 | positive regulation of transcription, DNA-templated | 12805222|17593335 |
| Hgene | DVL2 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 17593335 |
| Hgene | DVL2 | GO:0060070 | canonical Wnt signaling pathway | 17593335 |
| Hgene | DVL2 | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 12805222 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-0966-01A | DVL2 | chr17 | 7129740 | - | TMEM256 | chr17 | 7307008 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000005340 | ENST00000302422 | DVL2 | chr17 | 7129740 | - | TMEM256 | chr17 | 7307008 | - |
| In-frame | ENST00000575458 | ENST00000302422 | DVL2 | chr17 | 7129740 | - | TMEM256 | chr17 | 7307008 | - |
| intron-3CDS | ENST00000574642 | ENST00000302422 | DVL2 | chr17 | 7129740 | - | TMEM256 | chr17 | 7307008 | - |
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FusionProtFeatures for DVL2_TMEM256 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DVL2 | TMEM256 |
| Plays a role in the signal transduction pathwaysmediated by multiple Wnt genes. Participates both in canonical andnon-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signalto down-stream effectors. Promotes internalization and degradationof frizzled proteins upon Wnt signaling.{ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 235_240 | 587 | 737 | Compositional bias | Note=Poly-Arg |
| Hgene | DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 7_12 | 587 | 737 | Compositional bias | Note=Poly-Gly |
| Hgene | DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 11_93 | 587 | 737 | Domain | DIX |
| Hgene | DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 267_339 | 587 | 737 | Domain | PDZ |
| Hgene | DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 433_507 | 587 | 737 | Domain | DEP |
| Tgene | >TMEM256 | chr17:7129740 | chr17:7307008 | ENST00000302422 | - | 0 | 4 | 30_63 | 28 | 114 | Topological domain | Extracellular |
| Tgene | >TMEM256 | chr17:7129740 | chr17:7307008 | ENST00000302422 | - | 0 | 4 | 85_92 | 28 | 114 | Topological domain | Cytoplasmic |
| Tgene | >TMEM256 | chr17:7129740 | chr17:7307008 | ENST00000302422 | - | 0 | 4 | 64_84 | 28 | 114 | Transmembrane | Helical |
| Tgene | >TMEM256 | chr17:7129740 | chr17:7307008 | ENST00000302422 | - | 0 | 4 | 93_113 | 28 | 114 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DVL2 | chr17:7129740 | chr17:7307008 | ENST00000005340 | - | 14 | 15 | 686_694 | 587 | 737 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for DVL2_TMEM256 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DVL2_ENST00000005340_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_673aa MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTG GPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTL NMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQ AYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIP NAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLP GATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLL >In-frame_DVL2_ENST00000575458_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_667aa MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLV SSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLE RHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYN FLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLP RNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGS DVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWP LLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLLASGTTL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DVL2_ENST00000005340_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_2019nt ATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTGGGGAGACGAAGGTGATTTACCACCTGGATGAGGAAGAGACTCCCTACCTGGTGAAG ATCCCTGTCCCCGCCGAGCGCATCACCCTCGGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTTTTTCAAGTCTATG GATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAGATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGTATCCTGGCTGGTG TCCTCAGATAATCCCCAACCCGAGATGGCCCCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACCTTTACCTCCTTTG CCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGCCTCCATCCTTCCACCCTAATGTGTCCAGCAGCCATGAGAATCTGGAGCCTGAG ACAGAAACCGAGTCAGTAGTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATGGCGCTGGGGGCCACAGGACTGGT GGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACGAGAGCTCCTCTACCCTCATGACCAGCGAGCTGGAGAGTACCAGCCTGGGGGAC TCGGACGAGGAGGACACCATGAGCAGGTTCAGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTTAAGCGCCACCGGCGGCGAAGG AAGCAGAGGCCACCCCGCCTGGAGAGGACGTCATCCTTCAGCAGCGTCACAGATTCCACAATGTCTCTCAATATCATCACAGTCACGCTA AACATGGAGAAGTACAACTTCCTGGGTATCTCCATTGTTGGCCAGAGCAATGAGCGGGGAGACGGAGGCATCTACATTGGCTCCATCATG AAGGGTGGGGCTGTGGCGGCCGACGGGCGCATTGAGCCAGGGGACATGCTTTTGCAGGTGAATGACATGAACTTTGAGAACATGAGCAAC GATGACGCTGTGCGGGTGCTGAGGGACATTGTGCACAAGCCTGGCCCCATTGTGCTGACTGTGGCCAAGTGCTGGGATCCCTCTCCTCAG GCCTATTTCACTCTCCCCCGAAATGAGCCCATCCAGCCAATTGACCCTGCTGCCTGGGTGTCCCATTCCGCGGCTCTGACTGGCACCTTC CCAGCCTATCCAGGTTCCTCCTCCATGAGCACCATTACATCTGGATCGTCTTTGCCTGATGGCTGTGAAGGCCGGGGTCTCTCCGTCCAT ACGGACATGGCATCGGTGACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGGAAGTCCGGGACCGCATGTGGCTCAAGATCACCATCCCT AATGCCTTTCTGGGCTCGGATGTGGTTGACTGGCTCTACCATCACGTGGAGGGCTTTCCTGAGCGGCGGGAGGCCCGCAAGTATGCCAGC GGGCTGCTCAAAGCAGGCCTGATCCGACACACCGTCAACAAGATCACCTTCTCTGAGCAGTGCTATTACGTCTTCGGAGACCTCAGTGGT GGCTGTGAGAGCTACCTAGTCAACCTGTCTCTCAATGACAACGATGGCTCCAGTGGGGCTTCAGACCAGGATACCCTGGCTCCTCTGCCT GGGGCCACCCCCTGGCCCCTGCTGCCCACTTTCTCCTACCAATACCCTGCCCCACACCCCTACAGCCCGCAGCCTCCACCCTACCATGAG CTTTCATCTTACACCTATGGTGGGGGCAGTGCCAGCAGCCAGCATAGTGAGGGCGCCCAATTCCCAGATGCCTACGGGAAGGAGCTGTTT GACAAGGCCAACAAACACCACTTCTTACACAGCCTGGCCCTGTTAGGGGTGCCCCATTGCAGAAAGCCACTCTGGGCTGGGTTATTGCTA GCTTCCGGAACGACCTTATTCTGCACCAGCTTTTACTACCAGGCTCTGAGTGGAGACCCCAGCATCCAGACTTTGGCCCCTGCGGGAGGG >In-frame_DVL2_ENST00000575458_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_2001nt ATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTGGGGAGACGAAGGTGATTTACCACCTGGATGAGGAAGAGACTCCCTACCTGGTGAAG ATCCCTGTCCCCGCCGAGCGCATCACCCTCGGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTTTTTCAAGTCTATG GATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAGATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGTATCCTGGCTGGTG TCCTCAGATAATCCCCAACCCGAGATGGCCCCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACCTTTACCTCCTTTG CCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGCCTCCATCCTTCCACCATGAGAATCTGGAGCCTGAGACAGAAACCGAGTCAGTA GTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATGGCGCTGGGGGCCACAGGACTGGTGGCCCCTCAAGGCTGGAG CGCCACCTGGCCGGATACGAGAGCTCCTCTACCCTCATGACCAGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACGAGGAGGACACC ATGAGCAGGTTCAGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTTAAGCGCCACCGGCGGCGAAGGAAGCAGAGGCCACCCCGC CTGGAGAGGACGTCATCCTTCAGCAGCGTCACAGATTCCACAATGTCTCTCAATATCATCACAGTCACGCTAAACATGGAGAAGTACAAC TTCCTGGGTATCTCCATTGTTGGCCAGAGCAATGAGCGGGGAGACGGAGGCATCTACATTGGCTCCATCATGAAGGGTGGGGCTGTGGCG GCCGACGGGCGCATTGAGCCAGGGGACATGCTTTTGCAGGTGAATGACATGAACTTTGAGAACATGAGCAACGATGACGCTGTGCGGGTG CTGAGGGACATTGTGCACAAGCCTGGCCCCATTGTGCTGACTGTGGCCAAGTGCTGGGATCCCTCTCCTCAGGCCTATTTCACTCTCCCC CGAAATGAGCCCATCCAGCCAATTGACCCTGCTGCCTGGGTGTCCCATTCCGCGGCTCTGACTGGCACCTTCCCAGCCTATCCAGGTTCC TCCTCCATGAGCACCATTACATCTGGATCGTCTTTGCCTGATGGCTGTGAAGGCCGGGGTCTCTCCGTCCATACGGACATGGCATCGGTG ACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGGAAGTCCGGGACCGCATGTGGCTCAAGATCACCATCCCTAATGCCTTTCTGGGCTCG GATGTGGTTGACTGGCTCTACCATCACGTGGAGGGCTTTCCTGAGCGGCGGGAGGCCCGCAAGTATGCCAGCGGGCTGCTCAAAGCAGGC CTGATCCGACACACCGTCAACAAGATCACCTTCTCTGAGCAGTGCTATTACGTCTTCGGAGACCTCAGTGGTGGCTGTGAGAGCTACCTA GTCAACCTGTCTCTCAATGACAACGATGGCTCCAGTGGGGCTTCAGACCAGGATACCCTGGCTCCTCTGCCTGGGGCCACCCCCTGGCCC CTGCTGCCCACTTTCTCCTACCAATACCCTGCCCCACACCCCTACAGCCCGCAGCCTCCACCCTACCATGAGCTTTCATCTTACACCTAT GGTGGGGGCAGTGCCAGCAGCCAGCATAGTGAGGGCGCCCAATTCCCAGATGCCTACGGGAAGGAGCTGTTTGACAAGGCCAACAAACAC CACTTCTTACACAGCCTGGCCCTGTTAGGGGTGCCCCATTGCAGAAAGCCACTCTGGGCTGGGTTATTGCTAGCTTCCGGAACGACCTTA TTCTGCACCAGCTTTTACTACCAGGCTCTGAGTGGAGACCCCAGCATCCAGACTTTGGCCCCTGCGGGAGGGACCCTGCTACTCTTGGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DVL2_ENST00000005340_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_2393nt AAGTCACGTGACATGAGGAGAGGTGGGCGGGTACCTGGAGGAAGCTCGCGGCGTCGGTGGCGGTGGCGCGCGGCGGCCGCTGAGACCGGG GCTTTGAGTCGCACCCCGCGGCCCGCCCCCCGCCGCCACCCTCGCAGATCCGTGCTTTTTCCCCTTTGCTTCTCTCCCGTACTGGGTCAG TCCTGTCCGCGCTCGCGCGTCGGTTTGCGGGTGTGCGCAGGCGCGGCAGGGGCCATTAGCCCTTTGGGTGGGCGGTGGAGCCCGGGAGCG CGCGGGCGAGACCATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTGGGGAGACGAAGGTGATTTACCACCTGGATGAGGAAGAGACTCC CTACCTGGTGAAGATCCCTGTCCCCGCCGAGCGCATCACCCTCGGCGATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTT TTTCAAGTCTATGGATCAGGATTTCGGGGTGGTGAAGGAAGAAATTTCAGATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGT ATCCTGGCTGGTGTCCTCAGATAATCCCCAACCCGAGATGGCCCCTCCAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACC TTTACCTCCTTTGCCACCCGAGAGGACCAGCGGCATTGGGGACTCAAGGCCTCCATCCTTCCACCCTAATGTGTCCAGCAGCCATGAGAA TCTGGAGCCTGAGACAGAAACCGAGTCAGTAGTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAGACAGCAGTGAGCATGGCGCTGGGGG CCACAGGACTGGTGGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACGAGAGCTCCTCTACCCTCATGACCAGCGAGCTGGAGAGTAC CAGCCTGGGGGACTCGGACGAGGAGGACACCATGAGCAGGTTCAGCAGCTCCACGGAGCAGAGCAGTGCCTCCCGCCTCCTTAAGCGCCA CCGGCGGCGAAGGAAGCAGAGGCCACCCCGCCTGGAGAGGACGTCATCCTTCAGCAGCGTCACAGATTCCACAATGTCTCTCAATATCAT CACAGTCACGCTAAACATGGAGAAGTACAACTTCCTGGGTATCTCCATTGTTGGCCAGAGCAATGAGCGGGGAGACGGAGGCATCTACAT TGGCTCCATCATGAAGGGTGGGGCTGTGGCGGCCGACGGGCGCATTGAGCCAGGGGACATGCTTTTGCAGGTGAATGACATGAACTTTGA GAACATGAGCAACGATGACGCTGTGCGGGTGCTGAGGGACATTGTGCACAAGCCTGGCCCCATTGTGCTGACTGTGGCCAAGTGCTGGGA TCCCTCTCCTCAGGCCTATTTCACTCTCCCCCGAAATGAGCCCATCCAGCCAATTGACCCTGCTGCCTGGGTGTCCCATTCCGCGGCTCT GACTGGCACCTTCCCAGCCTATCCAGGTTCCTCCTCCATGAGCACCATTACATCTGGATCGTCTTTGCCTGATGGCTGTGAAGGCCGGGG TCTCTCCGTCCATACGGACATGGCATCGGTGACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGGAAGTCCGGGACCGCATGTGGCTCAA GATCACCATCCCTAATGCCTTTCTGGGCTCGGATGTGGTTGACTGGCTCTACCATCACGTGGAGGGCTTTCCTGAGCGGCGGGAGGCCCG CAAGTATGCCAGCGGGCTGCTCAAAGCAGGCCTGATCCGACACACCGTCAACAAGATCACCTTCTCTGAGCAGTGCTATTACGTCTTCGG AGACCTCAGTGGTGGCTGTGAGAGCTACCTAGTCAACCTGTCTCTCAATGACAACGATGGCTCCAGTGGGGCTTCAGACCAGGATACCCT GGCTCCTCTGCCTGGGGCCACCCCCTGGCCCCTGCTGCCCACTTTCTCCTACCAATACCCTGCCCCACACCCCTACAGCCCGCAGCCTCC ACCCTACCATGAGCTTTCATCTTACACCTATGGTGGGGGCAGTGCCAGCAGCCAGCATAGTGAGGGCGCCCAATTCCCAGATGCCTACGG GAAGGAGCTGTTTGACAAGGCCAACAAACACCACTTCTTACACAGCCTGGCCCTGTTAGGGGTGCCCCATTGCAGAAAGCCACTCTGGGC TGGGTTATTGCTAGCTTCCGGAACGACCTTATTCTGCACCAGCTTTTACTACCAGGCTCTGAGTGGAGACCCCAGCATCCAGACTTTGGC CCCTGCGGGAGGGACCCTGCTACTCTTGGGCTGGCTTGCCTTGGCTCTTTGAGCTCCCTTTTGCTTAATTACTGGGTTTTCTGGGCAGTT >In-frame_DVL2_ENST00000575458_chr17_7129740_-_TMEM256_ENST00000302422_chr17_7307008_-_2148nt AGGGGCCATTAGCCCTTTGGGTGGGCGGTGGAGCCCGGGAGCGCGCGGGCGAGACCATGGCGGGTAGCAGCACTGGGGGCGGTGGGGTTG GGGAGACGAAGGTGATTTACCACCTGGATGAGGAAGAGACTCCCTACCTGGTGAAGATCCCTGTCCCCGCCGAGCGCATCACCCTCGGCG ATTTCAAGAGCGTCCTGCAGCGGCCCGCGGGCGCCAAGTACTTTTTCAAGTCTATGGATCAGGATTTCGGGGTGGTGAAGGAAGAAATTT CAGATGACAACGCCCGCCTCCCCTGCTTCAACGGAAGGGTGGTATCCTGGCTGGTGTCCTCAGATAATCCCCAACCCGAGATGGCCCCTC CAGTCCATGAGCCTCGGGCAGAACTGGCGCCTCCAGCCCCACCTTTACCTCCTTTGCCACCCGAGAGGACCAGCGGCATTGGGGACTCAA GGCCTCCATCCTTCCACCATGAGAATCTGGAGCCTGAGACAGAAACCGAGTCAGTAGTGTCACTGAGGCGGGAGCGGCCTCGCAGGAGAG ACAGCAGTGAGCATGGCGCTGGGGGCCACAGGACTGGTGGCCCCTCAAGGCTGGAGCGCCACCTGGCCGGATACGAGAGCTCCTCTACCC TCATGACCAGCGAGCTGGAGAGTACCAGCCTGGGGGACTCGGACGAGGAGGACACCATGAGCAGGTTCAGCAGCTCCACGGAGCAGAGCA GTGCCTCCCGCCTCCTTAAGCGCCACCGGCGGCGAAGGAAGCAGAGGCCACCCCGCCTGGAGAGGACGTCATCCTTCAGCAGCGTCACAG ATTCCACAATGTCTCTCAATATCATCACAGTCACGCTAAACATGGAGAAGTACAACTTCCTGGGTATCTCCATTGTTGGCCAGAGCAATG AGCGGGGAGACGGAGGCATCTACATTGGCTCCATCATGAAGGGTGGGGCTGTGGCGGCCGACGGGCGCATTGAGCCAGGGGACATGCTTT TGCAGGTGAATGACATGAACTTTGAGAACATGAGCAACGATGACGCTGTGCGGGTGCTGAGGGACATTGTGCACAAGCCTGGCCCCATTG TGCTGACTGTGGCCAAGTGCTGGGATCCCTCTCCTCAGGCCTATTTCACTCTCCCCCGAAATGAGCCCATCCAGCCAATTGACCCTGCTG CCTGGGTGTCCCATTCCGCGGCTCTGACTGGCACCTTCCCAGCCTATCCAGGTTCCTCCTCCATGAGCACCATTACATCTGGATCGTCTT TGCCTGATGGCTGTGAAGGCCGGGGTCTCTCCGTCCATACGGACATGGCATCGGTGACCAAGGCCATGGCAGCTCCAGAGTCTGGACTGG AAGTCCGGGACCGCATGTGGCTCAAGATCACCATCCCTAATGCCTTTCTGGGCTCGGATGTGGTTGACTGGCTCTACCATCACGTGGAGG GCTTTCCTGAGCGGCGGGAGGCCCGCAAGTATGCCAGCGGGCTGCTCAAAGCAGGCCTGATCCGACACACCGTCAACAAGATCACCTTCT CTGAGCAGTGCTATTACGTCTTCGGAGACCTCAGTGGTGGCTGTGAGAGCTACCTAGTCAACCTGTCTCTCAATGACAACGATGGCTCCA GTGGGGCTTCAGACCAGGATACCCTGGCTCCTCTGCCTGGGGCCACCCCCTGGCCCCTGCTGCCCACTTTCTCCTACCAATACCCTGCCC CACACCCCTACAGCCCGCAGCCTCCACCCTACCATGAGCTTTCATCTTACACCTATGGTGGGGGCAGTGCCAGCAGCCAGCATAGTGAGG GCGCCCAATTCCCAGATGCCTACGGGAAGGAGCTGTTTGACAAGGCCAACAAACACCACTTCTTACACAGCCTGGCCCTGTTAGGGGTGC CCCATTGCAGAAAGCCACTCTGGGCTGGGTTATTGCTAGCTTCCGGAACGACCTTATTCTGCACCAGCTTTTACTACCAGGCTCTGAGTG GAGACCCCAGCATCCAGACTTTGGCCCCTGCGGGAGGGACCCTGCTACTCTTGGGCTGGCTTGCCTTGGCTCTTTGAGCTCCCTTTTGCT |
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FusionGenePPI for DVL2_TMEM256 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DVL2 | PCBD1, USP5, POLI, CCDC33, DPPA2, AP2M1, MCRS1, ARHGEF39, ARR3, U2AF2, TIFA, TCEB3B, DDI1, RNPS1, CPSF7, SNF8, SNIP1, CSNK1E, PRPF3, BAHD1, TP53, BAG3, TRAF2, ZNF263, RBPMS, ENKD1, OTULIN, AP1M1, SORBS3, RHOXF2, ZNF250, ZNF165, DVL2, THAP1, ZBTB8A, DAB2, CSNK2A1, CTNNB1, ARRB1, MAP3K1, AXIN1, SIRT1, MAP1LC3A, GABARAP, VHL, NHLRC1, ELAVL1, ITCH, RBFOX1, ATN1, LRRK2, LYN, CTBP2, PLA2G12A, GABARAPL1, SQSTM1, TARS, IRS1, IRS2, WWOX, RNF185, DVL1, DVL3, IQGAP1, NUMA1, WWTR1, PSMD8, PRG2, ZNRF3, RNF43, RASSF9, RASSF10, NTRK1, KIAA0753, MED4, SSX2IP, CEP128, CEP135, CEP44, ODF2, RPGRIP1L, CEP19, DYNLT1, LCA5, SASS6, EIF1B, UBAC1, RUSC1, ZBTB48, UIMC1, MAGOHB, PRKAA1, GMCL1P1, TPM3, WAS, YES1, NOL12, ZGPAT, XPO1, C1QBP, APC, HSPA5, TNFAIP1, COBLL1, ERC1, RSRC1, ARL6IP4, DDX41, NBAS, CWC25, C19orf33, PHLDB2, CWF19L2, FOXK1, FOXK2, ZBTB17, DACT1, FZD5, ATG14, PIK3R4, ATG16L1, WWP1, WWP2, EPN1, FBXL17, CUL3, TRIM29, NXF2, LRRC4C, OLFM2, STK11, ABL1, WT1, RNF41 | TMEM256 | HGH1, GPI, CALU, CDH2, VDAC3, VKORC1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, RPGRIP1L, DCTN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DVL2_TMEM256 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DVL2_TMEM256 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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