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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10717

FusionGeneSummary for DUSP9_UBB

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP9_UBB
Fusion gene ID: 10717
HgeneTgene
Gene symbol

DUSP9

UBB

Gene ID

1852

7314

Gene namedual specificity phosphatase 9ubiquitin B
SynonymsMKP-4|MKP4HEL-S-50
Cytomap

Xq28

17p11.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 9map kinase phosphatase 4mitogen-activated protein kinase phosphatase 4serine/threonine specific protein phosphatasepolyubiquitin-Bepididymis secretory protein Li 50polyubiquitin B
Modification date2018052320180523
UniProtAcc

Q99956

P0CG47

Ensembl transtripts involved in fusion geneENST00000477033, ENST00000370167, 
ENST00000342782, 
ENST00000302182, 
ENST00000535788, ENST00000578649, 
ENST00000395839, ENST00000395837, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 2=50
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: DUSP9 [Title/Abstract] AND UBB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBB

GO:0031398

positive regulation of protein ubiquitination

24660806

TgeneUBB

GO:0047497

mitochondrion transport along microtubule

17571083

TgeneUBB

GO:0051881

regulation of mitochondrial membrane potential

17571083

TgeneUBB

GO:0061136

regulation of proteasomal protein catabolic process

17571083

TgeneUBB

GO:1901214

regulation of neuron death

17571083

TgeneUBB

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

17571083


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ654128DUSP9chrX

152916182

-UBBchr17

16285234

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000477033ENST00000302182DUSP9chrX

152916182

-UBBchr17

16285234

+
intron-3CDSENST00000477033ENST00000535788DUSP9chrX

152916182

-UBBchr17

16285234

+
intron-intronENST00000477033ENST00000578649DUSP9chrX

152916182

-UBBchr17

16285234

+
intron-intronENST00000477033ENST00000395839DUSP9chrX

152916182

-UBBchr17

16285234

+
intron-intronENST00000477033ENST00000395837DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-3CDSENST00000370167ENST00000302182DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-3CDSENST00000370167ENST00000535788DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000370167ENST00000578649DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000370167ENST00000395839DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000370167ENST00000395837DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-3CDSENST00000342782ENST00000302182DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-3CDSENST00000342782ENST00000535788DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000342782ENST00000578649DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000342782ENST00000395839DUSP9chrX

152916182

-UBBchr17

16285234

+
3UTR-intronENST00000342782ENST00000395837DUSP9chrX

152916182

-UBBchr17

16285234

+

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FusionProtFeatures for DUSP9_UBB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP9

Q99956

UBB

P0CG47

Inactivates MAP kinases. Has a specificity for the ERKfamily.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DUSP9_UBB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DUSP9_UBB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DUSP9_UBB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DUSP9_UBB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource