FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10709

FusionGeneSummary for DUSP22_TP53TG3

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP22_TP53TG3
Fusion gene ID: 10709
HgeneTgene
Gene symbol

DUSP22

TP53TG3

Gene ID

56940

24150

Gene namedual specificity phosphatase 22TP53 target 3
SynonymsJKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHXP53TG3|TP53TG3A|TP53TG3E|TP53TG3F
Cytomap

6p25.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 22JNK-stimulating phosphatase 1JNK-stimulatory phosphatase-1MAP kinase phosphatase xhomolog of mouse dual specificity phosphatase LMW-DSP2low molecular weight dual specificity phosphatase 2mitogen-activated proteTP53-target gene 3 proteinTP53-inducible gene 3 proteinp53 target gene 3
Modification date2018052320180519
UniProtAcc

Q9NRW4

Q9ULZ0

Ensembl transtripts involved in fusion geneENST00000344450, ENST00000603453, 
ENST00000605315, ENST00000419235, 
ENST00000605035, ENST00000605863, 
ENST00000603290, ENST00000604971, 
ENST00000398682, ENST00000569420, 
ENST00000568854, ENST00000398680, 
Fusion gene scores* DoF score4 X 2 X 4=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: DUSP22 [Title/Abstract] AND TP53TG3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-NA-A4QW-01ADUSP22chr6

311962

+TP53TG3chr16

32686386

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344450ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-intronENST00000344450ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-5UTRENST00000344450ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-intronENST00000344450ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603453ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603453ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-5UTRENST00000603453ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603453ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605315ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605315ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-5UTRENST00000605315ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605315ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-intronENST00000419235ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-intronENST00000419235ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-5UTRENST00000419235ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5CDS-intronENST00000419235ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5UTR-intronENST00000605035ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5UTR-intronENST00000605035ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5UTR-5UTRENST00000605035ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
5UTR-intronENST00000605035ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605863ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605863ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-5UTRENST00000605863ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000605863ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603290ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603290ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-5UTRENST00000603290ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000603290ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000604971ENST00000398682DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000604971ENST00000569420DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-5UTRENST00000604971ENST00000568854DUSP22chr6

311962

+TP53TG3chr16

32686386

-
intron-intronENST00000604971ENST00000398680DUSP22chr6

311962

+TP53TG3chr16

32686386

-

Top

FusionProtFeatures for DUSP22_TP53TG3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP22

Q9NRW4

TP53TG3

Q9ULZ0

Activates the Jnk signaling pathway. Dephosphorylatesand deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). {ECO:0000250,ECO:0000269|PubMed:11717427}. May play a significant role in p53/TP53-mediatingsignaling pathway. {ECO:0000269|PubMed:10534768}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DUSP22_TP53TG3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DUSP22_TP53TG3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DUSP22HOXA1, HSD17B4, RPL27A, DUSP22, ARF5, TAGLN2, DUSP23, VTI1B, SVIP, PGRMC1, PGRMC2, RAB14, DUSP28, TMEM11, HMOX2, NME1, MFF, KRAS, TMX1, PRAF2, MOSPD1, SRPR, RAB5C, PTRH2, RAB5A, APRT, HRAS, MCL1, APOL2, ATXN10, GNAI3, SAMM50, SNAP23, SYNGR1, GNAI1, ERGIC1, GNAI2, MTCH1, DCAKD, RAB10, RAB9A, STX16, TLDC1, WDR18, NME3, CYB5B, FAM177A1, TIMM17B, TMCO1, PCYOX1, RAP1A, NME2P1, TMEM70, CHP1, TIMM17A, MTCH2, QKI, ARF1, CHCHD3, ARF4, TMX3, ARL1, SCAMP3, TOMM40, PPM1A, CANT1, TMUB1, IGKC, DIABLO, GNA14, NRN1, CCNYL1, LARS2, GNAQ, HPCAL1, ERICH5, C12orf75, PTPRG, POTEF, KCTD21, ARFIP2, UBTD2, FBXO7, INPP5A, LAMTOR1, ULBP3, ULBP2, PAG1, IKBIP, EIF4E2, CTNNA2, SRP54, GNA11, SPECC1L, GNG5, YES1, VAMP3, GNA13, CSNK1G3, LAMTOR4, PALM, CUEDC1, GNAO1TP53TG3ELAVL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DUSP22_TP53TG3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DUSP22_TP53TG3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource