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Fusion gene ID: 10698 |
FusionGeneSummary for DUSP16_GPRC5D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DUSP16_GPRC5D | Fusion gene ID: 10698 | Hgene | Tgene | Gene symbol | DUSP16 | GPRC5D | Gene ID | 80824 | 55507 |
| Gene name | dual specificity phosphatase 16 | G protein-coupled receptor class C group 5 member D | |
| Synonyms | MKP-7|MKP7 | - | |
| Cytomap | 12p13.2 | 12p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity protein phosphatase 16MAP kinase phosphatase 7MAPK phosphatase-7mitogen-activated protein kinase phosphatase 7 | G-protein coupled receptor family C group 5 member Dorphan G-protein coupled receptor | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BY84 | Q9NZD1 | |
| Ensembl transtripts involved in fusion gene | ENST00000228862, ENST00000298573, ENST00000545864, | ENST00000228887, ENST00000396333, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: DUSP16 [Title/Abstract] AND GPRC5D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DUSP16 | GO:0016311 | dephosphorylation | 24531476 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-D8-A147-01A | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000228862 | ENST00000228887 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| In-frame | ENST00000228862 | ENST00000396333 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| intron-3CDS | ENST00000298573 | ENST00000228887 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| intron-3CDS | ENST00000298573 | ENST00000396333 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| 5UTR-3CDS | ENST00000545864 | ENST00000228887 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
| 5UTR-3CDS | ENST00000545864 | ENST00000396333 | DUSP16 | chr12 | 12653453 | - | GPRC5D | chr12 | 13093783 | - |
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FusionProtFeatures for DUSP16_GPRC5D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DUSP16 | GPRC5D |
| Dual specificity protein phosphatase involved in theinactivation of MAP kinases. Dephosphorylates MAPK10 bound toARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DUSP16_GPRC5D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DUSP16_ENST00000228862_chr12_12653453_-_GPRC5D_ENST00000396333_chr12_13093783_-_179aa MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DUSP16_ENST00000228862_chr12_12653453_-_GPRC5D_ENST00000396333_chr12_13093783_-_539nt ATGGCCCATGAGATGATTGGAACTCAAATTGTTACTGAGAGGTTGGTGGCTCTGCTGGAAAGTGGAACGGAAAAAGTGCTGCTAATTGAT AGCCGGCCATTTGTGGAATACAATACATCCCACATTTTGGAAGCCATTAATATCAACTGCTCCAAGCTTATGAAGCGAAGGTTGCAACAG GACAAAGTGTTAATTACAGAGCTCATCCAGCATTCAGCGAAACATAAGGTTGACATTGATTGCAGTCAGAAGGTTGTAGTTTACGATCAA AGCTCCCAAGATGTTGCCTCTCTCTCTTCAGACTGTTTTCTCACTGTACTTCTGGGTAAACTGGAGAAGAGCTTCAACTCTGTTCACCTG CTTGCAGGTGGGTTTGCTGAGTTCTCTCGTTGTTTCCCTGGCCTCTGTGAAGGAAAATCCACTCTAGTCCCTACCTGCATTTCTCAGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DUSP16_ENST00000228862_chr12_12653453_-_GPRC5D_ENST00000396333_chr12_13093783_-_1171nt GGAAGAGAAAGAGTGAAGAAAAGTTGCGAGCGTCTCCTCTCTTCCTAAGCCTCCCGCCCCAACCCACCCCTCAGAGAAGGAGAAGATAAT ATACTGAAAAGAAGAGGAGGAGGAGAGCGACGGGACGGGACGCGAGCGGGAGCGCAGCCGCCCTCTCGGCTCCGCGGCGGCGCCTCGCAA GTCCGGGAGGCGAGGGGGGCCCGAGGGGAGACGCCGTGACAACTTTCGTTTCCCTCTGAGGGAATTGGGAGGTCGGCGGCCCCAAAAGCT TTCAGTCCAGTGTAAAGCTGTTGGAGCGCGGGAGCAAAGGTAAAGAATGATGTAATGCGCTGGCTGCTCCAAAGCATCTTTTGTTGTGGA ATGGTTATTCCAGTCATCTCTTTATGAATCAAATGTGAGGGGCTGCTTTGTGGACGGAGTCCTTTGCAAGAGCACATCAACGGGAAAGAG AAAGAGACATTCACTTGGAGGGCTCTTGCTGAAAATGGGTTTAACTCTCCTTTTGCCAGTCACCACCAGCCTGACCTCATACACTTTTAG TACAATGGAGTGGCTGAGCCTTTGAGCACACCACCATTACATCATCGTGGCAAATTAAAGAAGGAGGTGGGAAAAGAGGACTTATTGTTG TCATGGCCCATGAGATGATTGGAACTCAAATTGTTACTGAGAGGTTGGTGGCTCTGCTGGAAAGTGGAACGGAAAAAGTGCTGCTAATTG ATAGCCGGCCATTTGTGGAATACAATACATCCCACATTTTGGAAGCCATTAATATCAACTGCTCCAAGCTTATGAAGCGAAGGTTGCAAC AGGACAAAGTGTTAATTACAGAGCTCATCCAGCATTCAGCGAAACATAAGGTTGACATTGATTGCAGTCAGAAGGTTGTAGTTTACGATC AAAGCTCCCAAGATGTTGCCTCTCTCTCTTCAGACTGTTTTCTCACTGTACTTCTGGGTAAACTGGAGAAGAGCTTCAACTCTGTTCACC TGCTTGCAGGTGGGTTTGCTGAGTTCTCTCGTTGTTTCCCTGGCCTCTGTGAAGGAAAATCCACTCTAGTCCCTACCTGCATTTCTCAGC CTTGCTTACCTGTTGCCAACATTGGGCCAACCCGAATTCTTCCCAATCTTTATCTTGGCTGCCAGCGAGATGTCCTCAACAAGACTGTTG |
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FusionGenePPI for DUSP16_GPRC5D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DUSP16 | MAPK8IP1, MAPK8IP2, MAPK14, MAPK9, MAPK10, MAPK1, MAPK8, FBXW7, DUSP16, MLF1, PTGES3, NXF2, AIP, KCTD20, YWHAB, HSPB1, HIGD1A, ARF5, DNAJB1, VBP1, DUSP8, ERBB4 | GPRC5D | SEC63, VPS45 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DUSP16_GPRC5D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP16_GPRC5D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DUSP16 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | GPRC5D | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Tgene | GPRC5D | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 2 | PSYGENET |
| Tgene | GPRC5D | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | GPRC5D | C0525045 | Mood Disorders | 1 | PSYGENET |
| Tgene | GPRC5D | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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