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Fusion gene ID: 10694 |
FusionGeneSummary for DUSP14_PHB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DUSP14_PHB | Fusion gene ID: 10694 | Hgene | Tgene | Gene symbol | DUSP14 | PHB | Gene ID | 11072 | 5245 |
| Gene name | dual specificity phosphatase 14 | prohibitin | |
| Synonyms | MKP-L|MKP6 | HEL-215|HEL-S-54e|PHB1 | |
| Cytomap | 17q12 | 17q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity protein phosphatase 14MAP kinase phosphatase 6MKP-1-like protein tyrosine phosphataseMKP-6mitogen-activated protein kinase phosphatase 6 | prohibitinepididymis luminal protein 215epididymis secretory sperm binding protein Li 54e | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O95147 | P35232 | |
| Ensembl transtripts involved in fusion gene | ENST00000394389, ENST00000394386, ENST00000487847, | ENST00000300408, ENST00000511832, ENST00000508009, | |
| Fusion gene scores | * DoF score | 4 X 2 X 2=16 | 6 X 3 X 4=72 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DUSP14 [Title/Abstract] AND PHB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PHB | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16964284 |
| Tgene | PHB | GO:0006355 | regulation of transcription, DNA-templated | 14500729 |
| Tgene | PHB | GO:0010944 | negative regulation of transcription by competitive promoter binding | 18487222 |
| Tgene | PHB | GO:0016575 | histone deacetylation | 12466959 |
| Tgene | PHB | GO:0045892 | negative regulation of transcription, DNA-templated | 12065415|12566959 |
| Tgene | PHB | GO:0045893 | positive regulation of transcription, DNA-templated | 14500729 |
| Tgene | PHB | GO:0045917 | positive regulation of complement activation | 17070910 |
| Tgene | PHB | GO:0050847 | progesterone receptor signaling pathway | 16964284 |
| Tgene | PHB | GO:0060766 | negative regulation of androgen receptor signaling pathway | 16964284 |
| Tgene | PHB | GO:0071354 | cellular response to interleukin-6 | 17324931 |
| Tgene | PHB | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway | 16964284 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A1HO-01A | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000394389 | ENST00000300408 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| 5UTR-3CDS | ENST00000394389 | ENST00000511832 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| 5UTR-5UTR | ENST00000394389 | ENST00000508009 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-3CDS | ENST00000394386 | ENST00000300408 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-3CDS | ENST00000394386 | ENST00000511832 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-5UTR | ENST00000394386 | ENST00000508009 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-3CDS | ENST00000487847 | ENST00000300408 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-3CDS | ENST00000487847 | ENST00000511832 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
| intron-5UTR | ENST00000487847 | ENST00000508009 | DUSP14 | chr17 | 35850064 | + | PHB | chr17 | 47486835 | - |
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FusionProtFeatures for DUSP14_PHB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DUSP14 | PHB |
| Involved in the inactivation of MAP kinases.Dephosphorylates ERK, JNK and p38 MAP-kinases. | Prohibitin inhibits DNA synthesis. It has a role inregulating proliferation. As yet it is unclear if the protein orthe mRNA exhibits this effect. May play a role in regulatingmitochondrial respiration activity and in aging.{ECO:0000269|PubMed:11302691}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DUSP14_PHB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DUSP14_PHB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DUSP14 | CD28, UCHL5, ISYNA1, SPERT, NXF1, BMI1, COASY, PMM1, OTULIN, B3GALNT1, RAB11B, OR51E2, P2RY8, CCDC51, TFG, SGOL2, MAPK9, LACC1, SMARCD1, TRAF2, EGFR, AP3B1, NUDT5, PYCR1, PYCR2, CPLX3, MAS1, OAZ3, KIF3A, FBXL4, IL31RA, SYT16, ACOX1, FOXP2, CCDC173, RASGRP4, SETDB2, GDF5, NSMAF, GPBP1, FAM136A, MRPL38, ACAD8, PYHIN1, RHOBTB2, ST6GALNAC3, PI4KA, LPCAT4, RAB11FIP4, HEATR1, LMTK2, AATK, ERBB4, ERBB2, ERBB3, FGFR2, ROR1, ROR2, IGF1R, PTK7, EPHA2, EPHA1 | PHB | E2F1, HDAC1, TP53, ANXA2, ACTN1, NCOR1, SIN3A, SMARCA4, SMARCA2, RAF1, RB1, RBL2, RBL1, BRE, MYOD1, CLN3, AR, MGMT, ESR1, PHB2, RNF2, UBC, ICT1, CD4, HDAC5, SKP2, CUL3, CDK2, SYNCRIP, UQCRC2, XPO1, YWHAE, EPAS1, TRAF3IP1, FN1, VCAM1, C1QBP, ATF2, UBL4A, ITGA4, SLC25A5, RPL7, YWHAB, IPO11, VDAC2, RPS4X, COL9A2, IGHG1, CAPZA1, NPM1, ACTB, LMNA, SMG5, PLEC, GTF3C1, RAPH1, HSP90AB1, DBN1, PRKCD, YWHAZ, KRAS, ADRB2, LONRF3, COX6C, NAP1L1, FBXO6, PARP1, STAU1, SPRTN, HUWE1, FUS, CUL7, OBSL1, CCDC8, SUZ12, EED, RIC3, ATL3, BCAP29, BCAP31, AFG3L2, ATP1A1, ATP5B, ATP5L, CLTC, COX4I1, CYC1, DDOST, GOSR2, HSD17B10, HSD17B12, LMAN1, MTCH2, COX2, NDUFB4, OLA1, RAB1A, RAB1B, RAB2A, SCAMP2, SSR1, STOML2, TAGLN2, TPD52, UQCRQ, VCP, VDAC1, VDAC3, SSR3, NTRK1, FAP, BCAS3, CASC3, CCL5, ST14, MED20, MED23, PTPN1, RAB5C, TMPO, RAB7A, AKAP1, RAB11A, VAPA, EMC2, MTX2, FGFR1OP2, GOLT1B, TMEM63B, YIPF5, MMGT1, NF2, ESRRB, U2AF2, ARMC7, ZNF746, YIPF3, C11orf73, TPTE, STOM, CYLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DUSP14_PHB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP14_PHB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PHB | C0038356 | Stomach Neoplasms | 2 | CTD_human |
| Tgene | PHB | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | PHB | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Tgene | PHB | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | PHB | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | PHB | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | PHB | C0033941 | Psychoses, Substance-Induced | 1 | CTD_human |
| Tgene | PHB | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | PHB | C2239176 | Liver carcinoma | 1 | CTD_human |
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