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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10693

FusionGeneSummary for DUSP14_HEATR6

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP14_HEATR6
Fusion gene ID: 10693
HgeneTgene
Gene symbol

DUSP14

HEATR6

Gene ID

11072

63897

Gene namedual specificity phosphatase 14HEAT repeat containing 6
SynonymsMKP-L|MKP6ABC1
Cytomap

17q12

17q23.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 14MAP kinase phosphatase 6MKP-1-like protein tyrosine phosphataseMKP-6mitogen-activated protein kinase phosphatase 6HEAT repeat-containing protein 6amplified in breast cancer 1amplified in breast cancer protein 1
Modification date2018052320180519
UniProtAcc

O95147

Q6AI08

Ensembl transtripts involved in fusion geneENST00000394389, ENST00000394386, 
ENST00000487847, 
ENST00000184956, 
ENST00000585976, ENST00000585712, 
Fusion gene scores* DoF score4 X 2 X 2=1610 X 9 X 5=450
# samples 410
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/450*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUSP14 [Title/Abstract] AND HEATR6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-UL-AAZ6-01ADUSP14chr17

35850058

+HEATR6chr17

58121496

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000394389ENST00000184956DUSP14chr17

35850058

+HEATR6chr17

58121496

-
5UTR-3CDSENST00000394389ENST00000585976DUSP14chr17

35850058

+HEATR6chr17

58121496

-
5UTR-intronENST00000394389ENST00000585712DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-3CDSENST00000394386ENST00000184956DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-3CDSENST00000394386ENST00000585976DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-intronENST00000394386ENST00000585712DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-3CDSENST00000487847ENST00000184956DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-3CDSENST00000487847ENST00000585976DUSP14chr17

35850058

+HEATR6chr17

58121496

-
intron-intronENST00000487847ENST00000585712DUSP14chr17

35850058

+HEATR6chr17

58121496

-

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FusionProtFeatures for DUSP14_HEATR6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP14

O95147

HEATR6

Q6AI08

Involved in the inactivation of MAP kinases.Dephosphorylates ERK, JNK and p38 MAP-kinases. Amplification-dependent oncogene.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DUSP14_HEATR6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DUSP14_HEATR6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DUSP14CD28, UCHL5, ISYNA1, SPERT, NXF1, BMI1, COASY, PMM1, OTULIN, B3GALNT1, RAB11B, OR51E2, P2RY8, CCDC51, TFG, SGOL2, MAPK9, LACC1, SMARCD1, TRAF2, EGFR, AP3B1, NUDT5, PYCR1, PYCR2, CPLX3, MAS1, OAZ3, KIF3A, FBXL4, IL31RA, SYT16, ACOX1, FOXP2, CCDC173, RASGRP4, SETDB2, GDF5, NSMAF, GPBP1, FAM136A, MRPL38, ACAD8, PYHIN1, RHOBTB2, ST6GALNAC3, PI4KA, LPCAT4, RAB11FIP4, HEATR1, LMTK2, AATK, ERBB4, ERBB2, ERBB3, FGFR2, ROR1, ROR2, IGF1R, PTK7, EPHA2, EPHA1HEATR6CTDSP1, BSG, SPACA1, HLA-B, CD244, SLAMF1, GAS8, RBM15, RPP30, NTRK1, PTEN, SDC2, SNX21, C1orf85, CD79B, IQCF1, PDCD1, PRKAB1, ICAM1, NTRK3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DUSP14_HEATR6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DUSP14_HEATR6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource