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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10683

FusionGeneSummary for DUS2_HSD11B2

check button Fusion gene summary
Fusion gene informationFusion gene name: DUS2_HSD11B2
Fusion gene ID: 10683
HgeneTgene
Gene symbol

DUS2

HSD11B2

Gene ID

54920

3291

Gene namedihydrouridine synthase 2hydroxysteroid 11-beta dehydrogenase 2
SynonymsDUS2L|SMM1|URLC8AME|AME1|HSD11K|HSD2|SDR9C3
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
DescriptiontRNA-dihydrouridine(20) synthase [NAD(P)+]-likeSMM1 homologdihydrouridine synthase 2-like, SMM1 homologtRNA-dihydrouridine(20) synthase (NAD(P)(+))up-regulated in lung cancer protein 8corticosteroid 11-beta-dehydrogenase isozyme 2-HSD11 type II11-DH211-HSD type II11-beta-HSD type II11-beta-HSD211-beta-hydroxysteroid dehydrogenase type 211-beta-hydroxysteroid dehydrogenase type IINAD-dependent 11-beta-hydroxysteroid dehydrogenas
Modification date2018052220180519
UniProtAcc

Q9NX74

P80365

Ensembl transtripts involved in fusion geneENST00000565263, ENST00000358896, 
ENST00000432752, 
ENST00000567684, 
ENST00000326152, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 5 X 3=60
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUS2 [Title/Abstract] AND HSD11B2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUS2

GO:0060548

negative regulation of cell death

18096616


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EB-A3Y7-01ADUS2chr16

68105011

+HSD11B2chr16

67470152

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000565263ENST00000567684DUS2chr16

68105011

+HSD11B2chr16

67470152

+
5CDS-3UTRENST00000565263ENST00000326152DUS2chr16

68105011

+HSD11B2chr16

67470152

+
5CDS-3UTRENST00000358896ENST00000567684DUS2chr16

68105011

+HSD11B2chr16

67470152

+
5CDS-3UTRENST00000358896ENST00000326152DUS2chr16

68105011

+HSD11B2chr16

67470152

+
5CDS-3UTRENST00000432752ENST00000567684DUS2chr16

68105011

+HSD11B2chr16

67470152

+
5CDS-3UTRENST00000432752ENST00000326152DUS2chr16

68105011

+HSD11B2chr16

67470152

+

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FusionProtFeatures for DUS2_HSD11B2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUS2

Q9NX74

HSD11B2

P80365

Dihydrouridine synthase. Catalyzes the synthesis ofdihydrouridine, a modified base found in the D-loop of most tRNAs.Negatively regulates the activation of EIF2AK2/PKR.{ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DUS2_HSD11B2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DUS2_HSD11B2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DUS2TK1, SMN1, PVRL2, KANSL1HSD11B2KAT2B, KAT2A, CTBP1, HDAC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DUS2_HSD11B2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneHSD11B2P80365DB01185FluoxymesteroneCorticosteroid 11-beta-dehydrogenase isozyme 2small moleculeapproved|illicit
TgeneHSD11B2P80365DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2small moleculeapproved|vet_approved

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RelatedDiseases for DUS2_HSD11B2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHSD11B2C3887949Apparent mineralocorticoid excess12CTD_human;UNIPROT
TgeneHSD11B2C0020538Hypertensive disease4CTD_human;HPO
TgeneHSD11B2C0004096Asthma1CTD_human
TgeneHSD11B2C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
TgeneHSD11B2C0023890Liver Cirrhosis1CTD_human
TgeneHSD11B2C0027051Myocardial Infarction1CTD_human
TgeneHSD11B2C0027726Nephrotic Syndrome1CTD_human
TgeneHSD11B2C0032962Pregnancy Complications1CTD_human
TgeneHSD11B2C0342488Mineralocorticoid Excess Syndrome, Apparent1CTD_human;ORPHANET