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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10679

FusionGeneSummary for DUOXA1_DUOXA1

check button Fusion gene summary
Fusion gene informationFusion gene name: DUOXA1_DUOXA1
Fusion gene ID: 10679
HgeneTgene
Gene symbol

DUOXA1

DUOXA1

Gene ID

90527

90527

Gene namedual oxidase maturation factor 1dual oxidase maturation factor 1
SynonymsNIP|NUMBIP|molNIP|NUMBIP|mol
Cytomap

15q21.1

15q21.1

Type of geneprotein-codingprotein-coding
Descriptiondual oxidase maturation factor 1dual oxidase activator 1dual oxidase maturation factor 1 alphadual oxidase maturation factor 1 betadual oxidase maturation factor 1 deltadual oxidase maturation factor 1 gammahomolog of Drosophila Numb-interacting produal oxidase maturation factor 1dual oxidase activator 1dual oxidase maturation factor 1 alphadual oxidase maturation factor 1 betadual oxidase maturation factor 1 deltadual oxidase maturation factor 1 gammahomolog of Drosophila Numb-interacting pro
Modification date2018052320180523
UniProtAcc

Q1HG43

Q1HG43

Ensembl transtripts involved in fusion geneENST00000267803, ENST00000559014, 
ENST00000558996, ENST00000430224, 
ENST00000558422, ENST00000560572, 
ENST00000559407, 
ENST00000267803, 
ENST00000559014, ENST00000558996, 
ENST00000430224, ENST00000558422, 
ENST00000560572, ENST00000559407, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: DUOXA1 [Title/Abstract] AND DUOXA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK027187DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000267803ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000267803ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559014ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558996ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000430224ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000558422ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000560572ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000267803DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000559014DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000558996DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000430224DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000558422DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000560572DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-
intron-intronENST00000559407ENST00000559407DUOXA1chr15

45410757

-DUOXA1chr9

19380233

-

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FusionProtFeatures for DUOXA1_DUOXA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUOXA1

Q1HG43

DUOXA1

Q1HG43

May be required for the maturation and the transportfrom the endoplasmic reticulum to the plasma membrane offunctional DUOX1. {ECO:0000305|PubMed:16651268}. May be required for the maturation and the transportfrom the endoplasmic reticulum to the plasma membrane offunctional DUOX1. {ECO:0000305|PubMed:16651268}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DUOXA1_DUOXA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DUOXA1_DUOXA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DUOXA1_DUOXA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DUOXA1_DUOXA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource