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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10676

FusionGeneSummary for DTX4_MS4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX4_MS4A1
Fusion gene ID: 10676
HgeneTgene
Gene symbol

DTX4

MS4A1

Gene ID

23220

931

Gene namedeltex E3 ubiquitin ligase 4membrane spanning 4-domains A1
SynonymsRNF155B1|Bp35|CD20|CVID5|LEU-16|MS4A2|S7
Cytomap

11q12.1

11q12.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase DTX4RING finger protein 155RING-type E3 ubiquitin transferase DTX4deltex 4 homologdeltex 4, E3 ubiquitin ligasedeltex homolog 4deltex4protein deltex-4B-lymphocyte antigen CD20B-lymphocyte cell-surface antigen B1CD20 antigenCD20 receptorleukocyte surface antigen Leu-16membrane-spanning 4-domains, subfamily A, member 1
Modification date2018051920180522
UniProtAcc

Q9Y2E6

P11836

Ensembl transtripts involved in fusion geneENST00000532982, ENST00000227451, 
ENST00000531902, 
ENST00000345732, 
ENST00000532073, ENST00000534668, 
ENST00000528313, ENST00000534503, 
ENST00000389939, 
Fusion gene scores* DoF score4 X 4 X 4=641 X 1 X 1=1
# samples 41
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: DTX4 [Title/Abstract] AND MS4A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-2051-01ADTX4chr11

58949935

+MS4A1chr11

60229832

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000532982ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-3UTRENST00000532982ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000532982ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-3UTRENST00000227451ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
5CDS-5UTRENST00000227451ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000345732DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000532073DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000534668DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000528313DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-3UTRENST00000531902ENST00000534503DTX4chr11

58949935

+MS4A1chr11

60229832

+
intron-5UTRENST00000531902ENST00000389939DTX4chr11

58949935

+MS4A1chr11

60229832

+

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FusionProtFeatures for DTX4_MS4A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX4

Q9Y2E6

MS4A1

P11836

Regulator of Notch signaling, a signaling pathwayinvolved in cell-cell communications that regulates a broadspectrum of cell-fate determinations (By similarity). Functions asa ubiquitin ligase protein in vivo, mediating 'Lys48'-linkedpolyubiquitination and promoting degradation of TBK1, targeting toTBK1 requires interaction with NLRP4. {ECO:0000250,ECO:0000269|PubMed:22388039}. This protein may be involved in the regulation of B-cellactivation and proliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DTX4_MS4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DTX4_MS4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DTX4NLRP4, TBK1, HSP90AA1, NOTCH1MS4A1CD40, LCK, FYN, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, FMNL1, PRDM1, CCDC155, MDM2, CREB3, FBXW7, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DTX4_MS4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMS4A1P11836DB00073RituximabB-lymphocyte antigen CD20biotechapproved
TgeneMS4A1P11836DB06650OfatumumabB-lymphocyte antigen CD20biotechapproved
TgeneMS4A1P11836DB00078Ibritumomab tiuxetanB-lymphocyte antigen CD20biotechapproved|investigational
TgeneMS4A1P11836DB00081TositumomabB-lymphocyte antigen CD20biotechapproved|investigational
TgeneMS4A1P11836DB08935ObinutuzumabB-lymphocyte antigen CD20biotechapproved|investigational

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RelatedDiseases for DTX4_MS4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDTX4C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneDTX4C0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneMS4A1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneMS4A1C0007137Squamous cell carcinoma1CTD_human
TgeneMS4A1C0029927Ovarian Cysts1CTD_human
TgeneMS4A1C0152013Adenocarcinoma of lung (disorder)1CTD_human