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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10657

FusionGeneSummary for DTNB_EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNB_EXOC4
Fusion gene ID: 10657
HgeneTgene
Gene symbol

DTNB

EXOC4

Gene ID

1838

60412

Gene namedystrobrevin betaexocyst complex component 4
Synonyms-SEC8|SEC8L1|Sec8p
Cytomap

2p23.3

7q33

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin betaDTN-Bbeta-dystrobrevinexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2018052220180523
UniProtAcc

O60941

Q96A65

Ensembl transtripts involved in fusion geneENST00000496972, ENST00000405222, 
ENST00000407661, ENST00000406818, 
ENST00000407038, ENST00000404103, 
ENST00000407186, ENST00000288642, 
ENST00000545439, ENST00000472690, 
ENST00000253861, ENST00000539845, 
ENST00000393161, ENST00000545148, 
ENST00000460346, ENST00000541309, 
Fusion gene scores* DoF score6 X 6 X 7=25215 X 12 X 7=1260
# samples 815
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTNB [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LY-01BDTNBchr2

25896255

-EXOC4chr7

133160082

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000496972ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-3CDSENST00000496972ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-3CDSENST00000496972ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000496972ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000496972ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000496972ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000405222ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000405222ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000405222ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000405222ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000405222ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000405222ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407661ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407661ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407661ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407661ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407661ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407661ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000406818ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000406818ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000406818ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000406818ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000406818ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000406818ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407038ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407038ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407038ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407038ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407038ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407038ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000404103ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000404103ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000404103ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000404103ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000404103ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000404103ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407186ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407186ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000407186ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407186ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407186ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000407186ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000288642ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000288642ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000288642ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000288642ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000288642ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000288642ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000545439ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000545439ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-3CDSENST00000545439ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000545439ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000545439ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
5UTR-intronENST00000545439ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-3CDSENST00000472690ENST00000253861DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-3CDSENST00000472690ENST00000539845DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-3CDSENST00000472690ENST00000393161DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000472690ENST00000545148DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000472690ENST00000460346DTNBchr2

25896255

-EXOC4chr7

133160082

+
intron-intronENST00000472690ENST00000541309DTNBchr2

25896255

-EXOC4chr7

133160082

+

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FusionProtFeatures for DTNB_EXOC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNB

O60941

EXOC4

Q96A65

Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DTNB_EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DTNB_EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DTNBKIF5A, TSACC, NUP62, TRAF2, CCDC85B, PRTFDC1, BEGAIN, HMG20A, PPFIBP2, KIF5B, MLC1, DMD, DTNB, KRT31, VCP, PPFIA1, ABI2, MTUS2, GGA1, ABI3, CEP55, CEP63, NDEL1, USHBP1, DTNBP1, SPZ1, KRT40, TXLNA, ZBTB9, CASK, CCDC101, GAPDH, CEP128, TNS1, TNS3, SNTG2, CPNE5, RHPN1, COG6, OLFM2, TENC1EXOC4MYC, DLG3, EXOC3, GRIN2B, DLG4, EXOC7, GTF2E2, DISC1, DTNBP1, CEP63, EXOC1, MYO5A, EXOC2, EXOC8, EXOC5, IQCB1, EGFR, ATG5, ATG12, BECN1, SNAP29, BSG, TPM1, SETDB1, EXOC6, NTRK1, MED4, SCLT1, OFD1, PCM1, CNTROB, FGFR1OP, CEP128, CEP44, CNTRL, ODF2, DYNLT1, TMEM17, SNW1, CDC5L, PTAR1, MTMR4, STX11, IKBIP, IL1R2, GGA1, APLNR, EXOC3L2, EXOC6B, TSSC1, RABEP2, VPS51, RABEP1, RALB, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DTNB_EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DTNB_EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource