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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10654

FusionGeneSummary for DTNB_ADCY3

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNB_ADCY3
Fusion gene ID: 10654
HgeneTgene
Gene symbol

DTNB

ADCY3

Gene ID

1838

114

Gene namedystrobrevin betaadenylate cyclase 8
Synonyms-AC8|ADCY3|HBAC1
Cytomap

2p23.3

8q24.22

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin betaDTN-Bbeta-dystrobrevinadenylate cyclase type 8ATP pyrophosphate-lyase 8HEL-S-172mPadenylate cyclase 8 (brain)adenylate cyclase type VIIIadenylyl cyclase 8adenylyl cyclase-8, brainca(2+)/calmodulin-activated adenylyl cyclaseepididymis secretory sperm binding protein Li
Modification date2018052220180523
UniProtAcc

O60941

O60266

Ensembl transtripts involved in fusion geneENST00000496972, ENST00000405222, 
ENST00000407661, ENST00000406818, 
ENST00000407038, ENST00000404103, 
ENST00000407186, ENST00000288642, 
ENST00000545439, ENST00000472690, 
ENST00000260600, ENST00000405392, 
ENST00000450524, 
Fusion gene scores* DoF score6 X 6 X 7=2523 X 3 X 3=27
# samples 83
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DTNB [Title/Abstract] AND ADCY3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-ER-A42L-06ADTNBchr2

25896255

-ADCY3chr2

25057805

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000496972ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
intron-3CDSENST00000496972ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
intron-intronENST00000496972ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000405222ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000405222ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000405222ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407661ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407661ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000407661ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000406818ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000406818ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000406818ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407038ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407038ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000407038ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000404103ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000404103ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000404103ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407186ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000407186ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000407186ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000288642ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000288642ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000288642ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000545439ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-3CDSENST00000545439ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
5UTR-intronENST00000545439ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-
intron-3CDSENST00000472690ENST00000260600DTNBchr2

25896255

-ADCY3chr2

25057805

-
intron-3CDSENST00000472690ENST00000405392DTNBchr2

25896255

-ADCY3chr2

25057805

-
intron-intronENST00000472690ENST00000450524DTNBchr2

25896255

-ADCY3chr2

25057805

-

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FusionProtFeatures for DTNB_ADCY3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNB

O60941

ADCY3

O60266

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Participates in signalingcascades triggered by odorant receptors via its function in cAMPbiosynthesis. Required for the perception of odorants. Requiredfor normal sperm motility and normal male fertility. Plays a rolein regulating insulin levels and body fat accumulation in responseto a high fat diet. {ECO:0000250|UniProtKB:Q8VHH7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DTNB_ADCY3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DTNB_ADCY3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DTNBKIF5A, TSACC, NUP62, TRAF2, CCDC85B, PRTFDC1, BEGAIN, HMG20A, PPFIBP2, KIF5B, MLC1, DMD, DTNB, KRT31, VCP, PPFIA1, ABI2, MTUS2, GGA1, ABI3, CEP55, CEP63, NDEL1, USHBP1, DTNBP1, SPZ1, KRT40, TXLNA, ZBTB9, CASK, CCDC101, GAPDH, CEP128, TNS1, TNS3, SNTG2, CPNE5, RHPN1, COG6, OLFM2, TENC1ADCY3ADRB2, POPDC2, LGALS3, ANKMY2, SLC4A8, ASIC4, CNGA3, IL17RC, PCDHGA5, CD79B, IZUMO1, SLC17A2, KCNA5, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DTNB_ADCY3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DTNB_ADCY3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADCY3C0005586Bipolar Disorder1PSYGENET
TgeneADCY3C0011875Diabetic Angiopathies1CTD_human
TgeneADCY3C0525045Mood Disorders1PSYGENET