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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10646

FusionGeneSummary for DTNA_CD82

check button Fusion gene summary
Fusion gene informationFusion gene name: DTNA_CD82
Fusion gene ID: 10646
HgeneTgene
Gene symbol

DTNA

CD82

Gene ID

1837

3732

Gene namedystrobrevin alphaCD82 molecule
SynonymsD18S892E|DRP3|DTN|DTN-A|LVNC14F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27
Cytomap

18q12.1

11p11.2

Type of geneprotein-codingprotein-coding
Descriptiondystrobrevin alphadystrophin-related protein 3CD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27
Modification date2018052220180523
UniProtAcc

Q9Y4J8

P27701

Ensembl transtripts involved in fusion geneENST00000283365, ENST00000596745, 
ENST00000315456, ENST00000598334, 
ENST00000554864, ENST00000399121, 
ENST00000595022, ENST00000269190, 
ENST00000399097, ENST00000598774, 
ENST00000598142, ENST00000348997, 
ENST00000597599, ENST00000269191, 
ENST00000444659, ENST00000399113, 
ENST00000601125, ENST00000269192, 
ENST00000591182, ENST00000597674, 
ENST00000556414, ENST00000599844, 
ENST00000590831, ENST00000592449, 
ENST00000227155, ENST00000342935, 
ENST00000530931, 
Fusion gene scores* DoF score7 X 5 X 5=1755 X 3 X 4=60
# samples 75
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTNA [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TQ-A7RK-02BDTNAchr18

32346005

+CD82chr11

44609025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000283365ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000283365ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000283365ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000596745ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000596745ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000596745ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000315456ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000315456ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000315456ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598334ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598334ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598334ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000554864ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000554864ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000554864ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399121ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399121ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000399121ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000595022ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000595022ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000595022ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269190ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269190ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000269190ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-5UTRENST00000399097ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-5UTRENST00000399097ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5UTR-intronENST00000399097ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598774ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598774ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598774ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598142ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000598142ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000598142ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000348997ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000348997ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000348997ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000597599ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000597599ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000597599ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269191ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000269191ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000269191ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000444659ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000444659ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000444659ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399113ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-5UTRENST00000399113ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
5CDS-intronENST00000399113ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000601125ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000601125ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000601125ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000269192ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000269192ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000269192ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000591182ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000591182ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000591182ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000597674ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000597674ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000597674ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000556414ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000556414ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000556414ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000599844ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000599844ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000599844ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000590831ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000590831ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000590831ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000592449ENST00000227155DTNAchr18

32346005

+CD82chr11

44609025

+
intron-5UTRENST00000592449ENST00000342935DTNAchr18

32346005

+CD82chr11

44609025

+
intron-intronENST00000592449ENST00000530931DTNAchr18

32346005

+CD82chr11

44609025

+

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FusionProtFeatures for DTNA_CD82


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTNA

Q9Y4J8

CD82

P27701

Associates with CD4 or CD8 and delivers costimulatorysignals for the TCR/CD3 pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DTNA_CD82


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DTNA_CD82


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DTNADMD, KCNJ12, SYNM, UTRN, SNTA1, MARK2, GFI1B, SEC24C, NUP62, MYO1E, PSEN1, SEC23A, MLC1, TJP1, ACTB, ADRA1D, FYCO1, CCDC101, DTNBP1, NMT1, POTEI, SAR1A, SPZ1, DRP2, STAT3, CTDSPL, SNTG2, HMG20A, COG6, FAM167A, RAB30, TENC1CD82CD151, CD9, ERBB2, ERBB3, IGSF8, CD46, PTGFRN, CD63, HLA-DRA, HLA-DMB, HLA-DOB, HBEGF, CD4, CD19, ITGAL, EGFR, AMFR, LGALS3BP, GGT1, CD81, CD53, CREB3, NFKB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DTNA_CD82


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DTNA_CD82


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDTNAC1858725NONCOMPACTION OF LEFT VENTRICULAR MYOCARDIUM, FAMILIAL ISOLATED, AUTOSOMAL DOMINANT 11CTD_human;UNIPROT
TgeneCD82C0000786Spontaneous abortion1CTD_human
TgeneCD82C0027626Neoplasm Invasiveness1CTD_human
TgeneCD82C0027627Neoplasm Metastasis1CTD_human