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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10641

FusionGeneSummary for DTD1_TASP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DTD1_TASP1
Fusion gene ID: 10641
HgeneTgene
Gene symbol

DTD1

TASP1

Gene ID

92675

55617

Gene nameD-tyrosyl-tRNA deacylase 1taspase 1
SynonymsC20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68C20orf13|dJ585I14.2
Cytomap

20p11.23

20p12.1

Type of geneprotein-codingprotein-coding
DescriptionD-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2threonine aspartase 1
Modification date2018052320180523
UniProtAcc

Q8TEA8

Q9H6P5

Ensembl transtripts involved in fusion geneENST00000377452, ENST00000494921, 
ENST00000539805, ENST00000480436, 
ENST00000337743, ENST00000544472, 
Fusion gene scores* DoF score8 X 5 X 6=2406 X 6 X 4=144
# samples 88
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTD1 [Title/Abstract] AND TASP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-33-AAS8-01ADTD1chr20

18576885

+TASP1chr20

13246829

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000377452ENST00000539805DTD1chr20

18576885

+TASP1chr20

13246829

-
5CDS-intronENST00000377452ENST00000480436DTD1chr20

18576885

+TASP1chr20

13246829

-
5CDS-intronENST00000377452ENST00000337743DTD1chr20

18576885

+TASP1chr20

13246829

-
5CDS-intronENST00000377452ENST00000544472DTD1chr20

18576885

+TASP1chr20

13246829

-
3UTR-3UTRENST00000494921ENST00000539805DTD1chr20

18576885

+TASP1chr20

13246829

-
3UTR-intronENST00000494921ENST00000480436DTD1chr20

18576885

+TASP1chr20

13246829

-
3UTR-intronENST00000494921ENST00000337743DTD1chr20

18576885

+TASP1chr20

13246829

-
3UTR-intronENST00000494921ENST00000544472DTD1chr20

18576885

+TASP1chr20

13246829

-

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FusionProtFeatures for DTD1_TASP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTD1

Q8TEA8

TASP1

Q9H6P5

Protease involved in KMT2A/MLL1 processing and,consequently, in the correct expression of the early HOXA genecluster. {ECO:0000269|PubMed:14636557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DTD1_TASP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DTD1_TASP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DTD1IQCB1, CDC45, TOPBP1, CSNK2A1, ANKMY2, HSF1, CYP1A1, CSNK1E, HARS, MAN2B1, SH2D4A, NEK2, POLKTASP1APP, KMT2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DTD1_TASP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DTD1_TASP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource