FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10631

FusionGeneSummary for DST_PSMD2

check button Fusion gene summary
Fusion gene informationFusion gene name: DST_PSMD2
Fusion gene ID: 10631
HgeneTgene
Gene symbol

DST

PSMD2

Gene ID

667

5708

Gene namedystoninproteasome 26S subunit, non-ATPase 2
SynonymsBP240|BPA|BPAG1|CATX-15|CATX15|D6S1101|DMH|DT|EBSB2|HSAN6|MACF2P97|RPN1|S2|TRAP2
Cytomap

6p12.1

3q27.1

Type of geneprotein-codingprotein-coding
Descriptiondystoninbullous pemphigoid antigen 1dystonia musculorum proteinhemidesmosomal plaque proteintrabeculin-beta26S proteasome non-ATPase regulatory subunit 255.11 proteinTNFR-associated protein 2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2protein 55.11tumor necrosis factor type 1 receptor-associated protein 2
Modification date2018052320180523
UniProtAcc

Q03001

Q13200

Ensembl transtripts involved in fusion geneENST00000421834, ENST00000370769, 
ENST00000312431, ENST00000370754, 
ENST00000370788, ENST00000361203, 
ENST00000244364, ENST00000446842, 
ENST00000340834, ENST00000370765, 
ENST00000518935, 
ENST00000310118, 
ENST00000435761, ENST00000439383, 
ENST00000459910, 
Fusion gene scores* DoF score15 X 16 X 9=21605 X 6 X 1=30
# samples 177
** MAII scorelog2(17/2160*10)=-3.66742466091313
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/30*10)=1.22239242133645
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DST [Title/Abstract] AND PSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDST

GO:0009611

response to wounding

19403692


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF081412DSTchr6

56373505

+PSMD2chr3

184023926

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000421834ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000421834ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000421834ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000421834ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370769ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370769ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370769ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000370769ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000312431ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000312431ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000312431ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000312431ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370754ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370754ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370754ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000370754ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370788ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370788ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370788ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000370788ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000361203ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000361203ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000361203ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000361203ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000244364ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000244364ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000244364ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000244364ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000446842ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000446842ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000446842ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000446842ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000340834ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000340834ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000340834ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000340834ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370765ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370765ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000370765ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000370765ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000518935ENST00000310118DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000518935ENST00000435761DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-3CDSENST00000518935ENST00000439383DSTchr6

56373505

+PSMD2chr3

184023926

-
intron-intronENST00000518935ENST00000459910DSTchr6

56373505

+PSMD2chr3

184023926

-

Top

FusionProtFeatures for DST_PSMD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DST

Q03001

PSMD2

Q13200


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DST_PSMD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DST_PSMD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DST_PSMD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DST_PSMD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource