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Fusion gene ID: 10579 |
FusionGeneSummary for DSCR3_NIPBL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DSCR3_NIPBL | Fusion gene ID: 10579 | Hgene | Tgene | Gene symbol | DSCR3 | NIPBL | Gene ID | 25836 |
| Gene name | NIPBL, cohesin loading factor | ||
| Synonyms | CDLS|CDLS1|IDN3|IDN3-B|Scc2 | ||
| Cytomap | 5p13.2 | ||
| Type of gene | protein-coding | ||
| Description | nipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homolog | ||
| Modification date | 20180527 | ||
| UniProtAcc | O14972 | Q6KC79 | |
| Ensembl transtripts involved in fusion gene | ENST00000309117, ENST00000399000, ENST00000288304, ENST00000539844, ENST00000399001, ENST00000476950, ENST00000398998, | ENST00000282516, ENST00000448238, ENST00000504430, | |
| Fusion gene scores | * DoF score | 5 X 1 X 3=15 | 7 X 7 X 4=196 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DSCR3 [Title/Abstract] AND NIPBL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NIPBL | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18854353 |
| Tgene | NIPBL | GO:0031065 | positive regulation of histone deacetylation | 18854353 |
| Tgene | NIPBL | GO:0045892 | negative regulation of transcription, DNA-templated | 18854353 |
| Tgene | NIPBL | GO:0071921 | cohesin loading | 22628566 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DU-6406-01A | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000309117 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000309117 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5CDS-intron | ENST00000309117 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-3CDS | ENST00000399000 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-3CDS | ENST00000399000 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-intron | ENST00000399000 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-3CDS | ENST00000288304 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-3CDS | ENST00000288304 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5UTR-intron | ENST00000288304 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000539844 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000539844 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5CDS-intron | ENST00000539844 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000399001 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000399001 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5CDS-intron | ENST00000399001 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000476950 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000476950 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5CDS-intron | ENST00000476950 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000398998 | ENST00000282516 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| In-frame | ENST00000398998 | ENST00000448238 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
| 5CDS-intron | ENST00000398998 | ENST00000504430 | DSCR3 | chr21 | 38639539 | - | NIPBL | chr5 | 37019413 | + |
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FusionProtFeatures for DSCR3_NIPBL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DSCR3 | NIPBL |
| Plays an important role in the loading of the cohesincomplex on to DNA. Forms a heterodimeric complex (also known ascohesin loading complex) with MAU2/SCC4 which mediates the loadingof the cohesin complex onto chromatin (PubMed:22628566,PubMed:28914604). Plays a role in cohesin loading at sites of DNAdamage. Its recruitement to double-strand breaks (DSBs) sitesoccurs in a CBX3-, RNF8- and RNF168-dependent manner whereas itsrecruitement to UV irradiation-induced DNA damage sites occurs ina ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679).Along with ZNF609, promotes cortical neuron migration during braindevelopment by regulating the transcription of crucial genes inthis process. Preferentially binds promoters containing paused RNApolymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1and GABBR2 genes, among others (By similarity).{ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566,ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 1767_1805 | 1640 | 2805 | Repeat | Note=HEAT 1 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 1843_1881 | 1640 | 2805 | Repeat | Note=HEAT 2 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 1945_1984 | 1640 | 2805 | Repeat | Note=HEAT 3 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 2227_2267 | 1640 | 2805 | Repeat | Note=HEAT 4 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 2313_2351 | 1640 | 2805 | Repeat | Note=HEAT 5 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 1767_1805 | 1640 | 2698 | Repeat | Note=HEAT 1 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 1843_1881 | 1640 | 2698 | Repeat | Note=HEAT 2 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 1945_1984 | 1640 | 2698 | Repeat | Note=HEAT 3 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 2227_2267 | 1640 | 2698 | Repeat | Note=HEAT 4 |
| Tgene | >NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 2313_2351 | 1640 | 2698 | Repeat | Note=HEAT 5 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 418_462 | 1640 | 2805 | Compositional bias | Note=Gln-rich |
| Tgene | NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 418_462 | 1640 | 2698 | Compositional bias | Note=Gln-rich |
| Tgene | NIPBL | chr21:38639539 | chr5:37019413 | ENST00000282516 | + | 23 | 47 | 996_1009 | 1640 | 2805 | Motif | PxVxL motif |
| Tgene | NIPBL | chr21:38639539 | chr5:37019413 | ENST00000448238 | + | 23 | 46 | 996_1009 | 1640 | 2698 | Motif | PxVxL motif |
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FusionGeneSequence for DSCR3_NIPBL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_1184aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK RSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQM NESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQT >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_1077aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_1184aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK RSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQM NESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQT >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_1077aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_1184aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK RSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQM NESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQT >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_1077aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_1184aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK RSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQM NESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQT >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_1077aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_1184aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK RSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQM NESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQT >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_1077aa MGTALDIKIKRANKVYHAGVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEGTHHAKEIE TTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVA VDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFPKITEMCVK MIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEH ILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEE DLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDF KGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQEEDTRMQQA DRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQ LVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYI ADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINS VMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_3552nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA AGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATG AATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACC AGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCT TGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACT >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3231nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_3552nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA AGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATG AATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACC AGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCT TGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACT >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3231nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_3552nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA AGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATG AATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACC AGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCT TGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACT >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3231nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_3552nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA AGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATG AATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACC AGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCT TGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACT >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3231nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_3552nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA AGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATG AATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACC AGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCT TGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACT >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3231nt ATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTA CAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTT CGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAG ACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTA AAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGAT ATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCT GTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCA GTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGT ATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAA ATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAAT GACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTG CTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCAC ATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTA TTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTC ATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAA GATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAA AATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACT TCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTT AAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAA GCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCT GATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCA GATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTT TATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAA GGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAA CTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATC AACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGA AACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATA GCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGT AGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGC GACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCA GTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAA CATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAAC CGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAA AGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCT AGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_5311nt GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC AGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGC TATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGG CTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTAT TTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGAC TTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAA AAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTC GCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAA CTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGC GGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTA TTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACC CTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTG TTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGT TTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAG GGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTC AAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATT CTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTT GAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGAT GTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTG ACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCT GTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTG GCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATA >In-frame_DSCR3_ENST00000309117_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3636nt GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC AGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGT ACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTT >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_5101nt AAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTC AGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTC TCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGA AGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAA AACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTC CATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGC CATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGA TAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATAT GCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATT TCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAA ACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGA TACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTAC TCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATT GGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTAC CACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAG TGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCT TGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAG TCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCG GCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAA ACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGT GAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACA AGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTC AGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCT AAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACC TGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAA GATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTG TTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAA AACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCA TATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATC ATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGA TTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGG TATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATC TGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGC TAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGA AGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAA TACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTCATTGAGAAGGTCAAAACGAAATTC AGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTGCTGTCCAAAGTACAAAGATCGACC ACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTACAGTGGCTCCTGGACTGAGGCTAA GCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATTTACAAAAAAATTGCTCTAACGAGTGCTAA TAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACTTCCAGCTAATGAATTTGTACATGCAGCCA AATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAAAAATCAGTTTTATGAAGAGTAAGTGGAAC CTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCGCTGTTGTGCAGCAGAAACAGATTCTCAGT TCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAACTTTCTGTTTAAAAAAAATAAACAAGTGAA TGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCGGATGGCTTTCTTTAGCTTAGCCCAGTTTC CAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTATTCTGTTGAAAAAAAAAAAAGCATGCAGTA TCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCCTGAAAACAATACAAGAAAAGGGATCCCCA GGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGTTTCCATTTGAATTTCTTATTGTAAAAATC TGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTTTTCAAAGCAAAACATAAAATATTGTTTAT ACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGGGTGTAAACAATTAACTCCAGGGTTTTATT GTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCAAGAGTACATTTTGATATAAAAAGAAACTA TAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTCTTTAAACCTCGGGTAAAGGTAACCTGTTA TTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTGAGATGAATATGACACTTCATAATTACACT CACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATGTTTATTCATTTTCTAATCTATGCTAAAAG CTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGACTAAATCAGGAGGGAGGTGTTTAATCATT TGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTGTTTCAAGTTTAATTCTTTTTAAAAATGTT TTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGGCAAATAAATGAAGGTATTCAATTTTTGAG >In-frame_DSCR3_ENST00000539844_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3426nt AAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAATAAAGTTTATCACGCCGGGGTTTC AGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGAGACTGATCCTTCACTAGTGTTTTC TCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATCACAAAAAGATGAAGAATCATCTGA AGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAAAAAGTTTCTTAGAAGCATTATCAA AACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTGCTTGATTGTTCGATACTTGGCCTC CATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAATGCAATTGCTGTTCGAACAAAAGC CATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACGAGGTGTTCATGGACGATTGATGGA TAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCAGCTTGCTGAACAGTATTATGATAT GCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGACATTTGTATTGAACAACCAACATT TCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAAATTAGTAAATGAAACATTCCAGAA ACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTACCGATGTGGTTGCAGCATGCAGAGA TACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATATAAACCTGTGAAGAAAGCTTGTAC TCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAATAAAGGTGTGAATTCTGGAAGATT GGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGCAATGACTATGCAACCATACCTTAC CACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGTTGTACCACTGATGGAGCATCCAAG TGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGTAGTGCAACATTGTGTGAGCTGTCT TGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTATGGTGCCATTTCAAAATTAAAAAG TCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCTTTTCACCGTTGGAGCACTATGTCG GCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACTTGAACTATTGATGTATTTTACAAA ACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCCAAGTCTAATGTTCGAGCAAGAAGT GAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTTAAAAAACCTCCAGACCTACCTACA AGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTTAAAAGAAATGGGTGATGTTTCCTC AGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCAGTCAAGTGTACGCCACTTTGCCCT AAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAATTGCTATGGGCACAGACCCAGAACC TGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCATATGAAAGCAGTGGCTGGTATGAA GATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACAAGACGAGTCCTCTAGCGCTTTGTG TTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACTCAACCTCTTTGATGACACAGCAAA AACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGAAGAGCCGTTGTTTATAATGCATCA TATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAAGGACAAAAGGAAAGAGAGAAAATC ATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACGGAAACGTGTAGATTCAGATTCAGA TTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAATCGAATTTGCAAATGTGTCCCAGGG TATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAATTCAGAAGTACTCTCCATCTGAATC TGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACTGGACTTCCTGCGGAGTGACATGGC TAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCTCATGGAACATCTGGACCCTGATGA AGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCTTGGAGGAGGCAGCCCTAAAAATAA TACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGGTGAGGCGGAGGAGGAGTCAACGTAT TTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTACACCAAGTAATGTAATACTTAAAAGAGAA AACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTAACATAAAAGACAATAAAAAAACAGAAATG >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_5130nt CTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGA GCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAAC ACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATG AAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAAC CGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGAT GCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGT GAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATG CAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGA CCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTC AGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATT AAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAAC ATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCC TCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCT GACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAA CATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAG CTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATG ACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGA TACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGA TCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAA GTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAG CATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAA GTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAA GACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCAC ACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATAT TTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTC ATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTC AGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCT TTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACA CAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATG GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAG TCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCT TTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGT AAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAA ACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAA CTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCA CTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCA GGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCT ATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGC TCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATT TACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACT TCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAA AAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCG CTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAAC TTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCG GATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTAT TCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCC TGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGT TTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTT TTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGG GTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCA AGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTC TTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTG AGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATG TTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGA CTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTG TTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGG CAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATAA >In-frame_DSCR3_ENST00000399001_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3455nt CTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGA GCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAAC ACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATG AAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAAC CGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGAT GCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGT GAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATG CAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGA CCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTC AGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATT AAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAAC ATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCC TCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCT GACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAA CATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAG CTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATG ACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGA TACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGA TCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAA GTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAG CATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAA GTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAA GACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCAC ACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATAT TTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTC ATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTC AGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCT TTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACA CAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATG GTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAG TCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCT TTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGT AAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAA ACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAA CTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCA CTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCA GGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTA CACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTA >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_5125nt TTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAA TAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCT CATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCT TGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGTC ATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGCTATTTG CTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGGCTCCTA CAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTATTTACAA AAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGACTTCCAG CTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAAAAAATC AGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTCGCTGTT GTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAACTTTCT GTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGCGGATGG CTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTATTCTGT TGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACCCTGAAA ACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTGTTTCCA TTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGTTTTCAA AGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAGGGTGTA AACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTCAAGAGT ACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATTCTTTAA ACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTTGAGATG AATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGATGTTTAT TCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTGACTAAA TCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCTGTTTCA AGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTGGCAAAT >In-frame_DSCR3_ENST00000476950_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3450nt TTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAGAGCGAA TAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAACACTGA GACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAATGAAATC ACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAACCGAAA AAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGATGCTTG CTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGGTGAAAA TGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATATGCAACG AGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCGACCTCA GCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCTCAGAGA CATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCATTAAGAA ATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAACATTAC CGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTCCTCATA TAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTCTGACAA TAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAAACATGC AATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGAGCTAGT TGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCATGACTGT AGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAGATACTA TGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAGATCCCT TTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAAAGTACT TGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCAGCATCC AAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACAAGTGTT AAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGAAGACTT AAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCACACCCA GTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATATTTAAT TGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATTCATTCA TATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTTCAGACA AGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTCTTTACT CAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGACACAGGA AGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTATGGTAAA GGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAAGTCACG GAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCCTTTAAT CGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAGTAAAAT TCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACAAACACT GGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAAACTTCT CATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTCACTGCT TGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTCAGGGGT GAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGTACACCA AGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTTAACATA >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000282516_chr5_37019413_+_5311nt GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC AGGGTCATTGAGAAGGTCAAAACGAAATTCAGACTCTACGGAGTTGGCAGCACAGATGAATGAAAGTGTTGACGTCATGGATGTCATCGC TATTTGCTGTCCAAAGTACAAAGATCGACCACAAATTGCAAGAGTAGTGCAGAAAACCAGCAGTGGCTTCAGTGTTCAGTGGATGGCAGG CTCCTACAGTGGCTCCTGGACTGAGGCTAAGCGCCGTGATGGCCGCAAACTGGTGCCTTGGGTAGACACTATTAAAGAGTCAGACATTAT TTACAAAAAAATTGCTCTAACGAGTGCTAATAAGCTGACTAATAAAGTTGTTCAGACTTTACGATCCCTGTATGCCGCCAAGGATGGGAC TTCCAGCTAATGAATTTGTACATGCAGCCAAATTTACAGGAATTTTTTTAAAAGGCAGAAAAACTTGAAATACCAACATTCTGGCAAAAA AAAATCAGTTTTATGAAGAGTAAGTGGAACCTGGGATGCAGGAACAAAAGAAGGAAATGTTGGGCAAACATTTTTGTGGGAGCTCCCTTC GCTGTTGTGCAGCAGAAACAGATTCTCAGTTCATTTTTACTCCCACTGTATTATAGTTTAACAAAAATTGTTTATATCTTGGAAAAAAAA CTTTCTGTTTAAAAAAAATAAACAAGTGAATGTTGGAAATTAGTCTGTTAATGTTCTTAATAAAGTGTTCTTGGAGTTTAACCTAGCAGC GGATGGCTTTCTTTAGCTTAGCCCAGTTTCCAGGGAAGCATTGTTTTTTCCAGGCTGTAAAATGGCAGAATCTCCTGGATATATAATTTA TTCTGTTGAAAAAAAAAAAAGCATGCAGTATCTATGACCTATCTGCAGAAGGAGTTTTTGTAAATGTAGATTTTGATGTATTAGGTCACC CTGAAAACAATACAAGAAAAGGGATCCCCAGGTAATCTGGTGGAGCGAATACTGCAATAAATTTTTTTACTTCTCTTTGTTACTTGTCTG TTTCCATTTGAATTTCTTATTGTAAAAATCTGTTTAAATCCATTTATATTATTTTACAGTCTTTTATGTAAAATTTATTATATCACTGGT TTTCAAAGCAAAACATAAAATATTGTTTATACAGTTTGTATAGGCTGACTTCTGAATAATTGGTATCTATTATTTTCATTCCCATAAGAG GGTGTAAACAATTAACTCCAGGGTTTTATTGTATCCTGCAATATTTAGTATTAACTATATATGATTTAGCACTGTGCCAAACACATTTTC AAGAGTACATTTTGATATAAAAAGAAACTATAGTTTATTCCTTGTATGCTTCAATTTCTTTCTAGTGATGTCATGATGCTGATATTTATT CTTTAAACCTCGGGTAAAGGTAACCTGTTATTTGGAAAACCAGCATTTCTCTTGGTTAAAATGATGTCCGGTTATTTTAGAACTAGAGTT GAGATGAATATGACACTTCATAATTACACTCACTACATTTTTCACAAATTATTTTTTAATGCTGAAAAGAGTAATTTTACTTGTTGAGAT GTTTATTCATTTTCTAATCTATGCTAAAAGCTTTTATCATAAGTCTTGGGAACAGTTGTCATTTACACATTACTTACTGCAGATATCTTG ACTAAATCAGGAGGGAGGTGTTTAATCATTTGATATGTATAGTTGACACTCAGGAATAGTAATGCCTAAAATTTACAGTGGATGAGGTCT GTTTCAAGTTTAATTCTTTTTAAAAATGTTTTACTTATTTTTAAATCACTTTGAAAAAATTGACCTCCAGAATGCTGTTTTATGAAATTG GCAAATAAATGAAGGTATTCAATTTTTGAGGAAGAATGACATTGCCACAAAATACCTTTTTGTGACACCTATTAAACCACTATGAAAATA >In-frame_DSCR3_ENST00000398998_chr21_38639539_-_NIPBL_ENST00000448238_chr5_37019413_+_3636nt GGGGTGAACCGTGACAGCGCTTCGGCCCGCACTAAGGCCGGCTCTTGTGCCGGAAGGAGGAAGGCGTGGGCATTCGCCCCTCGGAGCTAG GGAGTGTGTGCGACGCCGCTGCGAGGTCACGTGAGCCACTGCCGGCAGAGAGGGAAAGGGGCGGGGCCCAGAACGAAGCGGGGAGGCGCC CCTTGTTTCCCTGGGGTCACGCGCAGCCGGAAGTGGCGGCTGCTGCGGAGAATTGGAGATGGGGACCGCCCTGGACATCAAGATTAAAAG AGCGAATAAAGTTTATCACGCCGGGGTTTCAGGAGGGGAAGATGAAATCCAACAATTACAAAAAGCATTGCTTGATTACTTGGATGAAAA CACTGAGACTGATCCTTCACTAGTGTTTTCTCGTAAATTCTATATAGCCCAGTGGTTTCGAGACACAACTCTGGAAACAGAAAAAGCAAT GAAATCACAAAAAGATGAAGAATCATCTGAAGGAACACATCATGCAAAGGAAATTGAGACAACTGGCCAAATTATGCATCGAGCTGAAAA CCGAAAAAAGTTTCTTAGAAGCATTATCAAAACCACACCTTCTCAGTTTAGCACATTAAAGATGAACTCTGATACTGTGGACTATGATGA TGCTTGCTTGATTGTTCGATACTTGGCCTCCATGAGGCCGTTTGCCCAGAGCTTTGATATTTATTTGACACAGATCCTACGAGTTCTTGG TGAAAATGCAATTGCTGTTCGAACAAAAGCCATGAAGTGTTTGTCTGAGGTTGTTGCTGTAGACCCCAGTATTCTAGCAAGGCTTGATAT GCAACGAGGTGTTCATGGACGATTGATGGATAATTCGACTAGTGTCCGAGAAGCAGCAGTAGAATTACTAGGTCGATTTGTCCTTTGTCG ACCTCAGCTTGCTGAACAGTATTATGATATGCTGATTGAAAGAATATTGGATACTGGTATCAGTGTCAGGAAAAGAGTAATAAAGATTCT CAGAGACATTTGTATTGAACAACCAACATTTCCAAAAATCACAGAAATGTGTGTAAAAATGATTCGCAGAGTCAATGATGAAGAGGGCAT TAAGAAATTAGTAAATGAAACATTCCAGAAACTCTGGTTTACTCCAACTCCACACAATGACAAAGAAGCAATGACAAGGAAAATTTTAAA CATTACCGATGTGGTTGCAGCATGCAGAGATACTGGATATGACTGGTTTGAGCAACTGCTTCAAAACTTGTTGAAGTCCGAAGAGGATTC CTCATATAAACCTGTGAAGAAAGCTTGTACTCAACTTGTTGATAACCTAGTTGAGCACATTCTTAAATATGAGGAATCTCTAGCTGACTC TGACAATAAAGGTGTGAATTCTGGAAGATTGGTAGCTTGCATAACCACTTTGTTCTTATTCAGCAAAATAAGACCCCAGCTCATGGTTAA ACATGCAATGACTATGCAACCATACCTTACCACTAAATGTAGTACGCAAAATGATTTCATGGTTATCTGCAATGTTGCAAAAATCCTAGA GCTAGTTGTACCACTGATGGAGCATCCAAGTGAAACTTTTCTTGCCACTATTGAGGAAGATCTAATGAAGCTCATCATCAAATATGGCAT GACTGTAGTGCAACATTGTGTGAGCTGTCTTGGAGCTGTTGTAAATAAAGTGACACAAAATTTTAAATTTGTGTGGGCTTGTTTCAATAG ATACTATGGTGCCATTTCAAAATTAAAAAGTCAACACCAAGAGGACCCAAATAACACTTCACTTCTAACAAACAAACCAGCACTTCTTAG ATCCCTTTTCACCGTTGGAGCACTATGTCGGCATTTTGATTTTGATCTGGAAGATTTTAAAGGCAACAGCAAGGTTAACATAAAAGATAA AGTACTTGAACTATTGATGTATTTTACAAAACACTCAGATGAAGAAGTACAAACAAAAGCTATCATTGGTCTAGGATTTGCCTTTATTCA GCATCCAAGTCTAATGTTCGAGCAAGAAGTGAAGAATCTATATAATAATATTTTATCTGATAAGAACTCCTCAGTCAATTTAAAAATACA AGTGTTAAAAAACCTCCAGACCTACCTACAAGAAGAAGATACACGTATGCAGCAGGCAGATAGAGACTGGAAGAAAGTTGCAAAACAGGA AGACTTAAAAGAAATGGGTGATGTTTCCTCAGGGATGAGTAGTTCCATCATGCAGCTTTATCTCAAACAGGTGCTTGAGGCATTTTTTCA CACCCAGTCAAGTGTACGCCACTTTGCCCTAAATGTCATTGCATTGACTCTAAATCAAGGTCTTATTCATCCAGTTCAGTGTGTGCCATA TTTAATTGCTATGGGCACAGACCCAGAACCTGCTATGCGGAACAAGGCTGATCAGCAACTTGTGGAAATAGACAAAAAATATGCTGGATT CATTCATATGAAAGCAGTGGCTGGTATGAAGATGTCTTACCAGGTACAACAGGCAATCAACACATGCCTAAAAGATCCTGTAAGGGGTTT CAGACAAGACGAGTCCTCTAGCGCTTTGTGTTCACACCTTTACTCCATGATCCGTGGAAACCGCCAACACAGACGAGCCTTTCTTATTTC TTTACTCAACCTCTTTGATGACACAGCAAAAACAGACGTGACTATGCTCTTGTATATAGCAGACAATCTAGCCTGTTTTCCATACCAGAC ACAGGAAGAGCCGTTGTTTATAATGCATCATATAGACATTACACTCTCAGTTTCTGGTAGTAACCTACTGCAGTCATTCAAGGAGTCTAT GGTAAAGGACAAAAGGAAAGAGAGAAAATCATCACCTAGTAAGGAAAATGAGTCAAGCGACAGTGAAGAAGAAGTTTCCAGGCCTCGGAA GTCACGGAAACGTGTAGATTCAGATTCAGATTCAGATTCAGAAGACGATATAAATTCAGTGATGAAATGTTTGCCAGAAAATTCAGCTCC TTTAATCGAATTTGCAAATGTGTCCCAGGGTATTTTATTACTTCTCATGTTAAAACAACATTTGAAGAATCTTTGTGGATTTTCTGATAG TAAAATTCAGAAGTACTCTCCATCTGAATCTGCAAAAGTATATGATAAAGCGATAAACCGAAAAACAGGAGTTCATTTTCATCCAAAACA AACACTGGACTTCCTGCGGAGTGACATGGCTAATTCCAAAATCACAGAAGAGGTGAAAAGGAGTATAGTAAAACAGTATCTAGATTTCAA ACTTCTCATGGAACATCTGGACCCTGATGAAGAAGAAGAAGAAGGGGAGGTTTCAGCTAGCACAAATGCTCGGAACAAAGCAATTACCTC ACTGCTTGGAGGAGGCAGCCCTAAAAATAATACAGCAGCAGAGACAGAAGATGATGAAAGTGATGGGGAGGATAGAGGAGGAGGCACTTC AGGGGTGAGGCGGAGGAGGAGTCAACGTATTTCGCAGCGTATTACGTAAAATGATTTTTATGTGCTTATATATGTCAGTCTATTAAATGT ACACCAAGTAATGTAATACTTAAAAGAGAAAACATTTTGTAGATAGAGATTCTCTACTTACCCGTTTATACATCCTTTTGTAGAAAGTTT |
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FusionGenePPI for DSCR3_NIPBL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DSCR3 | MAPK6, COMMD3, COMMD4, CCDC22, MAT1A, SH3GLB1, XPO7, CCDC93, COMMD8, VPS29, COMMD1, COMMD6, COMMD10, FAM45A, IL13RA2 | NIPBL | PRSS23, CBX5, SP100, CBX3, MLLT3, SMC1A, SMC3, MED23, CDK8, SIRT7, HINFP, TOMM40, PPT1, SF3A2, RAD21, MAU2, CDK6, RPA3, RPA2, RPA1, BRCA1, OBSL1, CCDC8, EED, EWSR1, RPL10, TFG, LDHD, SUCO, USP37, SNW1, CDC5L, ARFGAP1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DSCR3_NIPBL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DSCR3_NIPBL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NIPBL | C0270972 | Cornelia De Lange Syndrome | 9 | CTD_human;ORPHANET;UNIPROT |
| Tgene | NIPBL | C0005941 | Bone Diseases, Developmental | 1 | CTD_human |
| Tgene | NIPBL | C0018798 | Congenital Heart Defects | 1 | CTD_human |
| Tgene | NIPBL | C0260662 | Hearing problem | 1 | CTD_human |
| Tgene | NIPBL | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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