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Fusion gene ID: 10562 |
FusionGeneSummary for DROSHA_UGT3A2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DROSHA_UGT3A2 | Fusion gene ID: 10562 | Hgene | Tgene | Gene symbol | DROSHA | UGT3A2 | Gene ID | 29102 | 167127 |
Gene name | drosha ribonuclease III | UDP glycosyltransferase family 3 member A2 | |
Synonyms | ETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASEN | - | |
Cytomap | 5p13.3 | 5p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nuclear | UDP-glucuronosyltransferase 3A2UDP glycosyltransferase 3 family, polypeptide A2UDPGT 3A2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NRR4 | Q3SY77 | |
Ensembl transtripts involved in fusion gene | ENST00000511367, ENST00000442743, ENST00000344624, ENST00000513349, ENST00000504361, | ENST00000282507, ENST00000513300, ENST00000545528, ENST00000504954, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DROSHA [Title/Abstract] AND UGT3A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DROSHA | GO:0031053 | primary miRNA processing | 14508493|15574589 |
Hgene | DROSHA | GO:0050829 | defense response to Gram-negative bacterium | 20180804 |
Hgene | DROSHA | GO:0050830 | defense response to Gram-positive bacterium | 20180804 |
Tgene | UGT3A2 | GO:0071412 | cellular response to genistein | 22621930 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-HC-A9TE-01A | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000511367 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-intron | ENST00000511367 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000511367 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000511367 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
Frame-shift | ENST00000442743 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-intron | ENST00000442743 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000442743 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000442743 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
Frame-shift | ENST00000344624 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-intron | ENST00000344624 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000344624 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000344624 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
Frame-shift | ENST00000513349 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-intron | ENST00000513349 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000513349 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
5CDS-5UTR | ENST00000513349 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
intron-3CDS | ENST00000504361 | ENST00000282507 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
intron-intron | ENST00000504361 | ENST00000513300 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
intron-5UTR | ENST00000504361 | ENST00000545528 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
intron-5UTR | ENST00000504361 | ENST00000504954 | DROSHA | chr5 | 31526186 | - | UGT3A2 | chr5 | 36064452 | - |
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FusionProtFeatures for DROSHA_UGT3A2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DROSHA | UGT3A2 |
Ribonuclease III double-stranded (ds) RNA-specificendoribonuclease that is involved in the initial step of microRNA(miRNA) biogenesis. Component of the microprocessor complex thatis required to process primary miRNA transcripts (pri-miRNAs) torelease precursor miRNA (pre-miRNA) in the nucleus. Within themicroprocessor complex, DROSHA cleaves the 3' and 5' strands of astem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that aresubsequently cut by the cytoplasmic DICER to generate maturemiRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in theformation of GW bodies. {ECO:0000269|PubMed:10948199,ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877,ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589,ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099,ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994,ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}. | UDP-glucuronosyltransferases catalyze phase IIbiotransformation reactions in which lipophilic substrates areconjugated with glucuronic acid to increase water solubility andenhance excretion. They are of major importance in the conjugationand subsequent elimination of potentially toxic xenobiotics andendogenous compounds (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DROSHA_UGT3A2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DROSHA_UGT3A2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DROSHA | BCL6, DGCR8, PSMA1, CUL3, ZNF512B, SRPK2, SRPK1, WWOX, CARM1, HNRNPAB, HNRNPUL2, KHDRBS1, KLHL12, LGALS3BP, MEN1, PDCD6, PKP2, PPFIA1, RBM14, SKIV2L2, U2SURP, THRAP3, YLPM1, ZCCHC8, DDX5, NXF1, BMI1, CHRNA9, EVPL, PPL, SMC2, XPO1, LNPEP, NCK1, RPA1, ZNFX1, SGOL1, NR2E1, KHSRP | UGT3A2 | PTCH1, HTR3C, ACAT1, HTR3A, NCEH1, MPPE1, FUT1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DROSHA_UGT3A2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DROSHA_UGT3A2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DROSHA | C0021364 | Male infertility | 1 | CTD_human |
Hgene | DROSHA | C0036341 | Schizophrenia | 1 | PSYGENET |