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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10549

FusionGeneSummary for DRAM1_NTN4

check button Fusion gene summary
Fusion gene informationFusion gene name: DRAM1_NTN4
Fusion gene ID: 10549
HgeneTgene
Gene symbol

DRAM1

NTN4

Gene ID

55332

59277

Gene nameDNA damage regulated autophagy modulator 1netrin 4
SynonymsDRAMPRO3091
Cytomap

12q23.2

12q22

Type of geneprotein-codingprotein-coding
DescriptionDNA damage-regulated autophagy modulator protein 1damage-regulated autophagy modulatornetrin-4beta-netrinhepar-derived netrin-like protein
Modification date2018052320180519
UniProtAcc

Q8N682

Q9HB63

Ensembl transtripts involved in fusion geneENST00000258534, ENST00000544152, 
ENST00000343702, ENST00000344911, 
ENST00000538383, ENST00000553059, 
ENST00000552603, 
Fusion gene scores* DoF score5 X 3 X 5=756 X 5 X 3=90
# samples 56
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DRAM1 [Title/Abstract] AND NTN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDRAM1

GO:0010506

regulation of autophagy

19895784


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A23V-01ADRAM1chr12

102271698

+NTN4chr12

96063922

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000258534ENST00000343702DRAM1chr12

102271698

+NTN4chr12

96063922

-
Frame-shiftENST00000258534ENST00000344911DRAM1chr12

102271698

+NTN4chr12

96063922

-
Frame-shiftENST00000258534ENST00000538383DRAM1chr12

102271698

+NTN4chr12

96063922

-
5CDS-intronENST00000258534ENST00000553059DRAM1chr12

102271698

+NTN4chr12

96063922

-
5CDS-intronENST00000258534ENST00000552603DRAM1chr12

102271698

+NTN4chr12

96063922

-
Frame-shiftENST00000544152ENST00000343702DRAM1chr12

102271698

+NTN4chr12

96063922

-
Frame-shiftENST00000544152ENST00000344911DRAM1chr12

102271698

+NTN4chr12

96063922

-
Frame-shiftENST00000544152ENST00000538383DRAM1chr12

102271698

+NTN4chr12

96063922

-
5CDS-intronENST00000544152ENST00000553059DRAM1chr12

102271698

+NTN4chr12

96063922

-
5CDS-intronENST00000544152ENST00000552603DRAM1chr12

102271698

+NTN4chr12

96063922

-

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FusionProtFeatures for DRAM1_NTN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DRAM1

Q8N682

NTN4

Q9HB63

Lysosomal modulator of autophagy that plays a centralrole in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. {ECO:0000269|PubMed:16839881,ECO:0000269|PubMed:17304243}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DRAM1_NTN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DRAM1_NTN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DRAM1APP, C1orf21, CREB3NTN4PLSCR1, ADAMTSL4, CDKN1A, KRTAP5-9, ENO1, SHMT2, MOV10, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DRAM1_NTN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DRAM1_NTN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDRAM1C0023893Liver Cirrhosis, Experimental1CTD_human